Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P0A460 (T2D1_STRR6) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Type-2 restriction enzyme DpnI

Short name=R.DpnI
EC=3.1.21.4
Alternative name(s):
Endonuclease DpnI
Type II restriction enzyme DpnI
Gene names
Name:dpnC
Ordered Locus Names:spr1665
OrganismStreptococcus pneumoniae (strain ATCC BAA-255 / R6) [Reference proteome] [HAMAP]
Taxonomic identifier171101 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length254 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Recognizes the double-stranded and methylated sequence G(Me)ATC and cleaves after A-2 By similarity.

Catalytic activity

Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates.

Ontologies

Keywords
   Biological processRestriction system
   Molecular functionEndonuclease
Hydrolase
Nuclease
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA restriction-modification system

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionType II site-specific deoxyribonuclease activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 254254Type-2 restriction enzyme DpnI
PRO_0000077301

Secondary structure

................................................. 254
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P0A460 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: 7FFFFE14BB3EFEDB

FASTA25429,785
        10         20         30         40         50         60 
MELHFNLELV ETYKSNSQKA RILTEDWVYR QSYCPNCGNN PLNHFENNRP VADFYCNHCS 

        70         80         90        100        110        120 
EEFELKSKKG NFSSTINDGA YATMMKRVQA DNNPNFFFLT YTKNFEVNNF LVLPKQFVTP 

       130        140        150        160        170        180 
KSIIQRKPLA PTARRAGWIG CNIDLSQVPS KGRIFLVQDG QVRDPEKVTK EFKQGLFLRK 

       190        200        210        220        230        240 
SSLSSRGWTI EILNCIDKIE GSEFTLEDMY RFESDLKNIF VKNNHIKEKI RQQLQILRDK 

       250 
EIIEFKGRGK YRKL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE007317 Genomic DNA. Translation: AAL00468.1.
PIRG98079.
RefSeqNP_359257.1. NC_003098.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4ESJX-ray2.05A/B1-254[»]
ProteinModelPortalP0A460.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING171101.spr1665.

Protein family/group databases

REBASE5630. SpnRORF1665P.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL00468; AAL00468; spr1665.
GeneID933882.
KEGGspr:spr1665.
PATRIC19703368. VBIStrPne107296_1799.

Phylogenomic databases

eggNOGNOG11693.
HOGENOMHOG000067092.
KOK01155.
OMARAGWVGC.
OrthoDBEOG67Q982.
ProtClustDBCLSK878276.

Enzyme and pathway databases

BioCycSPNE171101:GJC8-1679-MONOMER.

Family and domain databases

InterProIPR010324. DRP.
[Graphical view]
PfamPF06044. DRP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameT2D1_STRR6
AccessionPrimary (citable) accession number: P0A460
Secondary accession number(s): P09356
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: April 16, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references