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P0A460

- T2D1_STRR6

UniProt

P0A460 - T2D1_STRR6

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Protein

Type-2 restriction enzyme DpnI

Gene

dpnC

Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Recognizes the double-stranded and methylated sequence G(Me)ATC and cleaves after A-2.By similarity

Catalytic activityi

Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates.

GO - Molecular functioni

  1. Type II site-specific deoxyribonuclease activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

Restriction system

Enzyme and pathway databases

BioCyciSPNE171101:GJC8-1679-MONOMER.

Protein family/group databases

REBASEi5630. SpnRORF1665P.

Names & Taxonomyi

Protein namesi
Recommended name:
Type-2 restriction enzyme DpnI (EC:3.1.21.4)
Short name:
R.DpnI
Alternative name(s):
Endonuclease DpnI
Type II restriction enzyme DpnI
Gene namesi
Name:dpnC
Ordered Locus Names:spr1665
OrganismiStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Taxonomic identifieri171101 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000586: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 254254Type-2 restriction enzyme DpnIPRO_0000077301Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi171101.spr1665.

Structurei

Secondary structure

1
254
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 126
Turni13 – 153
Helixi19 – 3113
Turni35 – 373
Beta strandi53 – 553
Turni57 – 593
Beta strandi62 – 7110
Beta strandi74 – 807
Helixi81 – 899
Beta strandi95 – 1017
Beta strandi105 – 1139
Helixi115 – 1173
Helixi120 – 1223
Beta strandi123 – 1297
Beta strandi138 – 1447
Helixi145 – 1473
Helixi150 – 1523
Beta strandi154 – 1585
Helixi165 – 17410
Helixi175 – 1806
Helixi183 – 19816
Beta strandi201 – 2055
Helixi206 – 2105
Helixi213 – 2197
Helixi226 – 23914
Beta strandi242 – 2454
Beta strandi250 – 2534

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4ESJX-ray2.05A/B1-254[»]
ProteinModelPortaliP0A460.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG11693.
HOGENOMiHOG000067092.
KOiK01155.
OMAiWIGCNIN.
OrthoDBiEOG67Q982.

Family and domain databases

InterProiIPR010324. DRP.
[Graphical view]
PfamiPF06044. DRP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A460-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELHFNLELV ETYKSNSQKA RILTEDWVYR QSYCPNCGNN PLNHFENNRP
60 70 80 90 100
VADFYCNHCS EEFELKSKKG NFSSTINDGA YATMMKRVQA DNNPNFFFLT
110 120 130 140 150
YTKNFEVNNF LVLPKQFVTP KSIIQRKPLA PTARRAGWIG CNIDLSQVPS
160 170 180 190 200
KGRIFLVQDG QVRDPEKVTK EFKQGLFLRK SSLSSRGWTI EILNCIDKIE
210 220 230 240 250
GSEFTLEDMY RFESDLKNIF VKNNHIKEKI RQQLQILRDK EIIEFKGRGK

YRKL
Length:254
Mass (Da):29,785
Last modified:March 15, 2005 - v1
Checksum:i7FFFFE14BB3EFEDB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE007317 Genomic DNA. Translation: AAL00468.1.
PIRiG98079.
RefSeqiNP_359257.1. NC_003098.1.

Genome annotation databases

EnsemblBacteriaiAAL00468; AAL00468; spr1665.
GeneIDi933882.
KEGGispr:spr1665.
PATRICi19703368. VBIStrPne107296_1799.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE007317 Genomic DNA. Translation: AAL00468.1 .
PIRi G98079.
RefSeqi NP_359257.1. NC_003098.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4ESJ X-ray 2.05 A/B 1-254 [» ]
ProteinModelPortali P0A460.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 171101.spr1665.

Protein family/group databases

REBASEi 5630. SpnRORF1665P.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL00468 ; AAL00468 ; spr1665 .
GeneIDi 933882.
KEGGi spr:spr1665.
PATRICi 19703368. VBIStrPne107296_1799.

Phylogenomic databases

eggNOGi NOG11693.
HOGENOMi HOG000067092.
KOi K01155.
OMAi WIGCNIN.
OrthoDBi EOG67Q982.

Enzyme and pathway databases

BioCyci SPNE171101:GJC8-1679-MONOMER.

Family and domain databases

InterProi IPR010324. DRP.
[Graphical view ]
Pfami PF06044. DRP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-255 / R6.

Entry informationi

Entry nameiT2D1_STRR6
AccessioniPrimary (citable) accession number: P0A460
Secondary accession number(s): P09356
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: October 1, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3