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P0A460

- T2D1_STRR6

UniProt

P0A460 - T2D1_STRR6

Protein

Type-2 restriction enzyme DpnI

Gene

dpnC

Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Recognizes the double-stranded and methylated sequence G(Me)ATC and cleaves after A-2.By similarity

    Catalytic activityi

    Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates.

    GO - Molecular functioni

    1. Type II site-specific deoxyribonuclease activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA restriction-modification system Source: UniProtKB-KW

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Keywords - Biological processi

    Restriction system

    Enzyme and pathway databases

    BioCyciSPNE171101:GJC8-1679-MONOMER.

    Protein family/group databases

    REBASEi5630. SpnRORF1665P.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type-2 restriction enzyme DpnI (EC:3.1.21.4)
    Short name:
    R.DpnI
    Alternative name(s):
    Endonuclease DpnI
    Type II restriction enzyme DpnI
    Gene namesi
    Name:dpnC
    Ordered Locus Names:spr1665
    OrganismiStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
    Taxonomic identifieri171101 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000586: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 254254Type-2 restriction enzyme DpnIPRO_0000077301Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi171101.spr1665.

    Structurei

    Secondary structure

    1
    254
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi7 – 126
    Turni13 – 153
    Helixi19 – 3113
    Turni35 – 373
    Beta strandi53 – 553
    Turni57 – 593
    Beta strandi62 – 7110
    Beta strandi74 – 807
    Helixi81 – 899
    Beta strandi95 – 1017
    Beta strandi105 – 1139
    Helixi115 – 1173
    Helixi120 – 1223
    Beta strandi123 – 1297
    Beta strandi138 – 1447
    Helixi145 – 1473
    Helixi150 – 1523
    Beta strandi154 – 1585
    Helixi165 – 17410
    Helixi175 – 1806
    Helixi183 – 19816
    Beta strandi201 – 2055
    Helixi206 – 2105
    Helixi213 – 2197
    Helixi226 – 23914
    Beta strandi242 – 2454
    Beta strandi250 – 2534

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4ESJX-ray2.05A/B1-254[»]
    ProteinModelPortaliP0A460.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG11693.
    HOGENOMiHOG000067092.
    KOiK01155.
    OMAiWIGCNIN.
    OrthoDBiEOG67Q982.

    Family and domain databases

    InterProiIPR010324. DRP.
    [Graphical view]
    PfamiPF06044. DRP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0A460-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELHFNLELV ETYKSNSQKA RILTEDWVYR QSYCPNCGNN PLNHFENNRP    50
    VADFYCNHCS EEFELKSKKG NFSSTINDGA YATMMKRVQA DNNPNFFFLT 100
    YTKNFEVNNF LVLPKQFVTP KSIIQRKPLA PTARRAGWIG CNIDLSQVPS 150
    KGRIFLVQDG QVRDPEKVTK EFKQGLFLRK SSLSSRGWTI EILNCIDKIE 200
    GSEFTLEDMY RFESDLKNIF VKNNHIKEKI RQQLQILRDK EIIEFKGRGK 250
    YRKL 254
    Length:254
    Mass (Da):29,785
    Last modified:March 15, 2005 - v1
    Checksum:i7FFFFE14BB3EFEDB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE007317 Genomic DNA. Translation: AAL00468.1.
    PIRiG98079.
    RefSeqiNP_359257.1. NC_003098.1.

    Genome annotation databases

    EnsemblBacteriaiAAL00468; AAL00468; spr1665.
    GeneIDi933882.
    KEGGispr:spr1665.
    PATRICi19703368. VBIStrPne107296_1799.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE007317 Genomic DNA. Translation: AAL00468.1 .
    PIRi G98079.
    RefSeqi NP_359257.1. NC_003098.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4ESJ X-ray 2.05 A/B 1-254 [» ]
    ProteinModelPortali P0A460.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 171101.spr1665.

    Protein family/group databases

    REBASEi 5630. SpnRORF1665P.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL00468 ; AAL00468 ; spr1665 .
    GeneIDi 933882.
    KEGGi spr:spr1665.
    PATRICi 19703368. VBIStrPne107296_1799.

    Phylogenomic databases

    eggNOGi NOG11693.
    HOGENOMi HOG000067092.
    KOi K01155.
    OMAi WIGCNIN.
    OrthoDBi EOG67Q982.

    Enzyme and pathway databases

    BioCyci SPNE171101:GJC8-1679-MONOMER.

    Family and domain databases

    InterProi IPR010324. DRP.
    [Graphical view ]
    Pfami PF06044. DRP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-255 / R6.

    Entry informationi

    Entry nameiT2D1_STRR6
    AccessioniPrimary (citable) accession number: P0A460
    Secondary accession number(s): P09356
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3