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P0A458

- T2A1_ANAVA

UniProt

P0A458 - T2A1_ANAVA

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Protein

Type-2 restriction enzyme AvaI

Gene
avaIR
Organism
Anabaena variabilis
Status
Reviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

Recognizes the double-stranded sequence CYCGRG and cleaves after C-1.

Catalytic activityi

Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates.

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. Type II site-specific deoxyribonuclease activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

Restriction system

Protein family/group databases

REBASEi165. AvaI.

Names & Taxonomyi

Protein namesi
Recommended name:
Type-2 restriction enzyme AvaI (EC:3.1.21.4)
Short name:
R.AvaI
Alternative name(s):
Endonuclease AvaI
Type II restriction enzyme AvaI
Gene namesi
Name:avaIR
OrganismiAnabaena variabilis
Taxonomic identifieri1172 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeAnabaena

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Type-2 restriction enzyme AvaIPRO_0000077280Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP0A458.
SMRiP0A458. Positions 1-315.

Family & Domainsi

Family and domain databases

Gene3Di3.40.91.10. 2 hits.
InterProiIPR011335. Restrct_endonuc-II-like.
IPR015277. Restrct_endonuc_II_AvaI/BsoBI.
IPR011544. Restrct_endonuc_II_Cfr10/BsoB1.
[Graphical view]
PfamiPF09194. Endonuc-BsobI. 1 hit.
[Graphical view]
ProDomiPD040871. Restrict_endonuc_II_AvaI/BsoBI. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF52980. SSF52980. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A458-1 [UniParc]FASTAAdd to Basket

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MPYQYHIQSN DDLVTPYQEV RAGFVALALE RNRKATPFVE QARALKIRVS    50
QIERPQDLLQ MRDIRPTLLA ASGVSDKAAG HLQEQDKVDA IEGLIQNFLE 100
PAGENFVEEL VYRFLLTRGD TLGGSMRNVG GILAERKFAR YIISALTLSN 150
TSYKWLDKNS KTWLNQPDDD TDIELRLRGL SWNLEGRNRT FIYNVNVPIV 200
RKNIDICLFD CRQNEIEKNI ISNPNIYIAL GELKGGIDPA GADEHWKTAN 250
SALARIRTAF DRHSLKPYTF FVGSAIEKSM AEEIWHQLNS GILTNAANLT 300
QPDQVASLCA WFIQL 315
Length:315
Mass (Da):35,679
Last modified:March 15, 2005 - v1
Checksum:i6F22C7CE4D329E33
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X98339 Genomic DNA. Translation: CAA66985.1.
PIRiS72472.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X98339 Genomic DNA. Translation: CAA66985.1 .
PIRi S72472.

3D structure databases

ProteinModelPortali P0A458.
SMRi P0A458. Positions 1-315.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

REBASEi 165. AvaI.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.91.10. 2 hits.
InterProi IPR011335. Restrct_endonuc-II-like.
IPR015277. Restrct_endonuc_II_AvaI/BsoBI.
IPR011544. Restrct_endonuc_II_Cfr10/BsoB1.
[Graphical view ]
Pfami PF09194. Endonuc-BsobI. 1 hit.
[Graphical view ]
ProDomi PD040871. Restrict_endonuc_II_AvaI/BsoBI. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF52980. SSF52980. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequence comparison of AvaI and BsoBI restriction-modification systems."
    Ruan H., Lunnen K.D., Scott M.E., Moran L.S., Slatko B.E., Pelletier J.J., Hess E.J., Benner J. II, Wilson G.G., Xu S.-Y.
    Mol. Gen. Genet. 252:695-699(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: PCC 7118 / ATCC 27892.

Entry informationi

Entry nameiT2A1_ANAVA
AccessioniPrimary (citable) accession number: P0A458
Secondary accession number(s): P70803
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: June 11, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries

External Data

Dasty 3

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