P0A3Z1 (AMPP1_STRCO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Xaa-Pro aminopeptidase 1
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase I
Aminopeptidase P I
Short name=APP
Short name=PEPP I
X-Pro aminopeptidase I
Xaa-Pro aminopeptidase I

Gene names

Name:	pepPI
Synonyms:	pepP
Ordered Locus Names:	SCO3970
ORF Names:	SCBAC25E3.07c

Organism

Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [Reference proteome] [HAMAP]

Taxonomic identifier

100226 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces › Streptomyces coelicolor

Protein attributes

Sequence length	491 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: InterPro metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 491	490	Xaa-Pro aminopeptidase 1		PRO_0000185079
Sites
	Metal binding	308	1	Manganese 2 By similarity
	Metal binding	320	1	Manganese 1 By similarity
	Metal binding	320	1	Manganese 2 By similarity
	Metal binding	403	1	Manganese 1 By similarity
	Metal binding	434	1	Manganese 1 By similarity
	Metal binding	458	1	Manganese 1 By similarity
	Metal binding	458	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0A3Z1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 1FE2C5E8C26C70DF	FASTA	491	54,048
	10 20 30 40 50 60 MAEELTPENP AIPETPEETE EPIKQRKNGL YPGVSDELAE NMQSGWADTE LHDLEPIAQA 70 80 90 100 110 120 AETAARRAAL SARFPGERLV IPAGNLKTRS NDTEYSFRAS VEYAYLTGNQ TEDGVLVMEP 130 140 150 160 170 180 EGDGHAATIY LLPRSDRENG EFWLDGQGEL WVGRRHSLAE AGELYGIPAS DVRELAGSLR 190 200 210 220 230 240 EATGPVRVVR GFDAGIEAAL TDKVTAERDE ELRVFLSEAR LVKDEFEIGE LQKAVDSTVR 250 260 270 280 290 300 GFEDVVKVLD RAEATSERYI EGTFFLRARV EGNDVGYGSI CAAGPHACTL HWVRNDGPVR 310 320 330 340 350 360 SGDLLLLDAG VETHTYYTAD VTRTLPISGT YSELQKKIYD AVYDAQEAGI AAVRPGAKYR 370 380 390 400 410 420 DFHDASQRVL AERLVEWGLV EGPVERVLEL GLQRRWTLHG TGHMLGMDVH DCAAARVESY 430 440 450 460 470 480 VDGTLEPGMV LTVEPGLYFQ ADDLTVPEEY RGIGVRIEDD ILVTADGNRN LSAGLPRRSD 490 EVEEWMAALK G

References

[1]

"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL939118 Genomic DNA. Translation: CAC44694.1.
RefSeq	NP_628153.1. NC_003888.3.
3D structure databases
ProteinModelPortal	P0A3Z1.
ModBase	Search...
Protein-protein interaction databases
STRING	100226.SCO3970.
Protein family/group databases
MEROPS	M24.033.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAC44694; CAC44694; CAC44694.
GeneID	1099406.
KEGG	sco:SCO3970.
PATRIC	23737724. VBIStrCoe124346_4043.
Phylogenomic databases
eggNOG	COG0006.
HOGENOM	HOG000008761.
KO	K01262.
OMA	HRRWMPH.
ProtClustDB	CLSK902138.
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR007865. Aminopep_P_N. IPR000994. Pept_M24_structural-domain. IPR001131. Peptidase_M24B_aminopep-P_CS. [Graphical view]
Pfam	PF05195. AMP_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SMART	SM01011. AMP_N. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP1_STRCO

Accession

Primary (citable) accession number: P0A3Z1
Secondary accession number(s): Q05813

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 55 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program