ID   TR2M_AGRTU              Reviewed;         755 AA.
AC   P0A3V3; P04029;
DT   23-OCT-1986, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   16-JUN-2009, entry version 24.
DE   RecName: Full=Tryptophan 2-monooxygenase;
DE            EC=1.13.12.3;
GN   Name=tms1;
OS   Agrobacterium tumefaciens.
OG   Plasmid pTiA6NC.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium.
OX   NCBI_TaxID=358;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=84170374; PubMed=6584906; DOI=10.1073/pnas.81.6.1728;
RA   Klee H., Montoya A., Horodyski F., Lichtenstein C., Garfinkel D.,
RA   Fuller S., Flores C., Peschon J., Nester E., Gordon M.;
RT   "Nucleotide sequence of the tms genes of the pTiA6NC octopine Ti
RT   plasmid: two gene products involved in plant tumorigenesis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 81:1728-1732(1984).
CC   -!- CATALYTIC ACTIVITY: L-tryptophan + O(2) = (indol-3-yl)acetamide +
CC       CO(2) + H(2)O.
CC   -!- PATHWAY: Plant hormone metabolism; auxin biosynthesis.
CC   -!- MISCELLANEOUS: The sequence shown is that of Ach5.
CC   -!- SIMILARITY: Belongs to the tryptophan 2-monooxygenase family.
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DR   EMBL; K02554; AAA92550.1; -; Genomic_DNA.
DR   PIR; A04497; QQAG4T.
DR   BioCyc; MetaCyc:MON-7863; -.
DR   BRENDA; 1.13.12.3; 2199.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0050361; F:tryptophan 2-monooxygenase activity; IEA:EC.
DR   GO; GO:0009851; P:auxin biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR000759; Adrndx_reductase.
DR   InterPro; IPR002937; Amino_oxidase.
DR   InterPro; IPR006064; Glycosidase.
DR   InterPro; IPR012142; Trp_2-mOase.
DR   Pfam; PF01593; Amino_oxidase; 1.
DR   Pfam; PF02027; RolB_RolC; 1.
DR   PIRSF; PIRSF000319; Trp_2-mono_O2ase; 1.
DR   PRINTS; PR00419; ADXRDTASE.
PE   3: Inferred from homology;
KW   Auxin biosynthesis; Crown gall tumor; Monooxygenase; Oxidoreductase;
KW   Plasmid.
FT   CHAIN         1    755       Tryptophan 2-monooxygenase.
FT                                /FTId=PRO_0000065587.
SQ   SEQUENCE   755 AA;  83892 MW;  84D2A325594964D8 CRC64;
     MSASPLLDNQ CDHLPTKMVD LTMVDKADEL DRRVSDAFLE REASRGRRIT QISTECSAGL
     ACKRLADGRF PEISAGGKVA VLSAYIYIGK EILGRILESK PWARATVSGL VAIDLAPFCM
     DFSEAQLIQA LFLLSGKRCA PIDLSHFVAI SISKTAGFRT LPMPLYENGT MKCVTGFTIT
     LEGAVPFDMV AYGRNLMLKG SAGSFPTIDL LYDYRPFFDQ CSDSGRIGFF PEDVPKPKVA
     VIGAGISGLV VANELLHAGV DDVTIYEASD RVGGKLWSHA FRDAPSVVAE MGAMRFPPAA
     FCLFFFLERY GLSSMRPFPN PGTVDTYLVY QGVQYMWKAG QLPPKLFHRV YNGWRAFLKD
     GFYERDIVLA SPVAITQALK SGDIRWAHDS WQIWLNRFGR ESFSSGIERI FLGTHPPGGE
     TWSFPHDWDL FKLMGIGSGG FGPVFESGFI EILRLVINGY EENQRMCPEG ISELPRRIAS
     EVVNGVSVSQ RICHVQVRAI QKEKTKIKIR LKSGISELYD KVVVTSGLAN IQLRHCLTCD
     TNIFQAPVNQ AVDNSHMTGS SKLFLMTERK FWLDHILPSC VLMDGIAKAV YCLDYEPQDP
     NGKGLVLISY TWEDDSHKLL AVPDKKERLC LLRDAISRSF PAFAQHLFPA CADYDQNVIQ
     HDWLTDENAG GAFKLNRRGE DFYSEELFFQ ALDTANDTGV YLAGCSCSFT GGWVEGAIQT
     ACNAVCAIIH NCGGILAKGN PLEHSWKRYN YRTRN
//