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Protein

Peptide methionine sulfoxide reductase MsrA/MsrB 1

Gene

msrAB1

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.By similarity

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.
L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.
Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei10 – 101By similarity
Active sitei284 – 2841NucleophilePROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciSPNE170187:GHGN-1365-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrA/MsrB 1
Including the following 2 domains:
Peptide methionine sulfoxide reductase MsrA (EC:1.8.4.11)
Short name:
Protein-methionine-S-oxide reductase
Alternative name(s):
Peptide-methionine (S)-S-oxide reductase
Short name:
Peptide Met(O) reductase
Peptide methionine sulfoxide reductase MsrB (EC:1.8.4.12)
Alternative name(s):
Peptide-methionine (R)-S-oxide reductase
Gene namesi
Name:msrAB1
Synonyms:exp3, msrA
Ordered Locus Names:SP_1359
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000585 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Peptide methionine sulfoxide reductase MsrA/MsrB 1PRO_0000138517Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi170187.SpneT_02001016.

Structurei

Secondary structure

1
312
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 76Combined sources
Helixi11 – 188Combined sources
Beta strandi24 – 3310Combined sources
Beta strandi35 – 373Combined sources
Turni41 – 433Combined sources
Helixi44 – 474Combined sources
Beta strandi50 – 578Combined sources
Turni59 – 613Combined sources
Helixi64 – 7411Combined sources
Beta strandi80 – 834Combined sources
Beta strandi86 – 883Combined sources
Helixi89 – 913Combined sources
Beta strandi94 – 985Combined sources
Helixi100 – 1023Combined sources
Helixi103 – 11715Combined sources
Beta strandi124 – 1274Combined sources
Beta strandi131 – 1333Combined sources
Helixi136 – 1383Combined sources
Helixi141 – 1444Combined sources
Helixi154 – 1574Combined sources
Helixi164 – 1674Combined sources
Helixi172 – 1787Combined sources
Helixi181 – 1899Combined sources
Beta strandi195 – 1984Combined sources
Turni199 – 2024Combined sources
Beta strandi206 – 2116Combined sources
Turni212 – 2143Combined sources
Beta strandi217 – 2204Combined sources
Helixi221 – 2233Combined sources
Beta strandi229 – 2313Combined sources
Beta strandi233 – 2364Combined sources
Helixi240 – 2423Combined sources
Beta strandi243 – 2486Combined sources
Beta strandi255 – 2639Combined sources
Beta strandi266 – 2727Combined sources
Turni276 – 2794Combined sources
Beta strandi282 – 2854Combined sources
Helixi287 – 2893Combined sources
Beta strandi290 – 2945Combined sources
Helixi295 – 3017Combined sources
Helixi304 – 3096Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3E0MX-ray2.40A/B/C/D1-312[»]
ProteinModelPortaliP0A3Q9.
SMRiP0A3Q9. Positions 1-163, 167-310.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A3Q9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini172 – 295124MsrBPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 155155Peptide methionine sulfoxide reductaseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the MsrA Met sulfoxide reductase family.Curated
In the C-terminal section; belongs to the MsrB Met sulfoxide reductase family.Curated
Contains 1 MsrB (methionine-R-sulfoxide reductase) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105E0X. Bacteria.
COG0225. LUCA.
COG0229. LUCA.
HOGENOMiHOG000243423.
KOiK12267.
OMAiTEESYRV.

Family and domain databases

Gene3Di2.170.150.20. 1 hit.
3.30.1060.10. 1 hit.
HAMAPiMF_01401. MsrA. 1 hit.
MF_01400. MsrB. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
IPR002579. Met_Sox_Rdtase_MsrB.
IPR011057. Mss4-like.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 2 hits.
PfamiPF01625. PMSR. 1 hit.
PF01641. SelR. 1 hit.
[Graphical view]
SUPFAMiSSF51316. SSF51316. 1 hit.
SSF55068. SSF55068. 1 hit.
TIGRFAMsiTIGR00401. msrA. 1 hit.
TIGR00357. TIGR00357. 1 hit.
PROSITEiPS51790. MSRB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A3Q9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEIYLAGGC FWGLEEYFSR ISGVLETSVG YANGQVETTN YQLLKETDHA
60 70 80 90 100
ETVQVIYDEK EVSLREILLY YFRVIDPLSI NQQGNDRGRQ YRTGIYYQDE
110 120 130 140 150
ADLPAIYTVV QEQERMLGRK IAVEVEQLRH YILAEDYHQD YLRKNPSGYC
160 170 180 190 200
HIDVTDADKP LIDAANYEKP SQEVLKASLS EESYRVTQEA ATEAPFTNAY
210 220 230 240 250
DQTFEEGIYV DITTGEPLFF AKDKFASGCG WPSFSRPISK ELIHYYKDLS
260 270 280 290 300
HGMERIEVRS RSGSAHLGHV FTDGPRELGG LRYCINSASL RFVAKDEMEK
310
AGYGYLLPYL NK
Length:312
Mass (Da):35,703
Last modified:March 15, 2005 - v1
Checksum:i6F3873FCE9C1F6E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005672 Genomic DNA. Translation: AAK75457.1.
PIRiH95157.
RefSeqiWP_000818207.1. NZ_AKVY01000001.1.

Genome annotation databases

EnsemblBacteriaiAAK75457; AAK75457; SP_1359.
KEGGispn:SP_1359.
PATRICi19707119. VBIStrPne105772_1402.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005672 Genomic DNA. Translation: AAK75457.1.
PIRiH95157.
RefSeqiWP_000818207.1. NZ_AKVY01000001.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3E0MX-ray2.40A/B/C/D1-312[»]
ProteinModelPortaliP0A3Q9.
SMRiP0A3Q9. Positions 1-163, 167-310.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi170187.SpneT_02001016.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK75457; AAK75457; SP_1359.
KEGGispn:SP_1359.
PATRICi19707119. VBIStrPne105772_1402.

Phylogenomic databases

eggNOGiENOG4105E0X. Bacteria.
COG0225. LUCA.
COG0229. LUCA.
HOGENOMiHOG000243423.
KOiK12267.
OMAiTEESYRV.

Enzyme and pathway databases

BioCyciSPNE170187:GHGN-1365-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0A3Q9.

Family and domain databases

Gene3Di2.170.150.20. 1 hit.
3.30.1060.10. 1 hit.
HAMAPiMF_01401. MsrA. 1 hit.
MF_01400. MsrB. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
IPR002579. Met_Sox_Rdtase_MsrB.
IPR011057. Mss4-like.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 2 hits.
PfamiPF01625. PMSR. 1 hit.
PF01641. SelR. 1 hit.
[Graphical view]
SUPFAMiSSF51316. SSF51316. 1 hit.
SSF55068. SSF55068. 1 hit.
TIGRFAMsiTIGR00401. msrA. 1 hit.
TIGR00357. TIGR00357. 1 hit.
PROSITEiPS51790. MSRB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSAB1_STRPN
AccessioniPrimary (citable) accession number: P0A3Q9
Secondary accession number(s): P35593
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: September 7, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Multifunctional enzyme

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.