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Protein

Peptide methionine sulfoxide reductase MsrA/MsrB 1

Gene

msrAB1

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.By similarity

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.
L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.
Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei10By similarity1
Active sitei284NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrA/MsrB 1
Including the following 2 domains:
Peptide methionine sulfoxide reductase MsrA (EC:1.8.4.11)
Short name:
Protein-methionine-S-oxide reductase
Alternative name(s):
Peptide-methionine (S)-S-oxide reductase
Short name:
Peptide Met(O) reductase
Peptide methionine sulfoxide reductase MsrB (EC:1.8.4.12)
Alternative name(s):
Peptide-methionine (R)-S-oxide reductase
Gene namesi
Name:msrAB1
Synonyms:exp3, msrA
Ordered Locus Names:SP_1359
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000585 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001385171 – 312Peptide methionine sulfoxide reductase MsrA/MsrB 1Add BLAST312

Interactioni

Protein-protein interaction databases

STRINGi170187.SpneT_02001016.

Structurei

Secondary structure

1312
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 7Combined sources6
Helixi11 – 18Combined sources8
Beta strandi24 – 33Combined sources10
Beta strandi35 – 37Combined sources3
Turni41 – 43Combined sources3
Helixi44 – 47Combined sources4
Beta strandi50 – 57Combined sources8
Turni59 – 61Combined sources3
Helixi64 – 74Combined sources11
Beta strandi80 – 83Combined sources4
Beta strandi86 – 88Combined sources3
Helixi89 – 91Combined sources3
Beta strandi94 – 98Combined sources5
Helixi100 – 102Combined sources3
Helixi103 – 117Combined sources15
Beta strandi124 – 127Combined sources4
Beta strandi131 – 133Combined sources3
Helixi136 – 138Combined sources3
Helixi141 – 144Combined sources4
Helixi154 – 157Combined sources4
Helixi164 – 167Combined sources4
Helixi172 – 178Combined sources7
Helixi181 – 189Combined sources9
Beta strandi195 – 198Combined sources4
Turni199 – 202Combined sources4
Beta strandi206 – 211Combined sources6
Turni212 – 214Combined sources3
Beta strandi217 – 220Combined sources4
Helixi221 – 223Combined sources3
Beta strandi229 – 231Combined sources3
Beta strandi233 – 236Combined sources4
Helixi240 – 242Combined sources3
Beta strandi243 – 248Combined sources6
Beta strandi255 – 263Combined sources9
Beta strandi266 – 272Combined sources7
Turni276 – 279Combined sources4
Beta strandi282 – 285Combined sources4
Helixi287 – 289Combined sources3
Beta strandi290 – 294Combined sources5
Helixi295 – 301Combined sources7
Helixi304 – 309Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3E0MX-ray2.40A/B/C/D1-312[»]
ProteinModelPortaliP0A3Q9.
SMRiP0A3Q9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A3Q9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini172 – 295MsrBPROSITE-ProRule annotationAdd BLAST124

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 155Peptide methionine sulfoxide reductaseAdd BLAST155

Sequence similaritiesi

In the N-terminal section; belongs to the MsrA Met sulfoxide reductase family.Curated
In the C-terminal section; belongs to the MsrB Met sulfoxide reductase family.Curated
Contains 1 MsrB (methionine-R-sulfoxide reductase) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105E0X. Bacteria.
COG0225. LUCA.
COG0229. LUCA.
HOGENOMiHOG000243423.
KOiK12267.
OMAiTEESYRV.

Family and domain databases

Gene3Di2.170.150.20. 1 hit.
3.30.1060.10. 1 hit.
HAMAPiMF_01401. MsrA. 1 hit.
MF_01400. MsrB. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
IPR002579. Met_Sox_Rdtase_MsrB.
IPR011057. Mss4-like.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 2 hits.
PfamiPF01625. PMSR. 1 hit.
PF01641. SelR. 1 hit.
[Graphical view]
SUPFAMiSSF51316. SSF51316. 1 hit.
SSF55068. SSF55068. 1 hit.
TIGRFAMsiTIGR00401. msrA. 1 hit.
TIGR00357. TIGR00357. 1 hit.
PROSITEiPS51790. MSRB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A3Q9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEIYLAGGC FWGLEEYFSR ISGVLETSVG YANGQVETTN YQLLKETDHA
60 70 80 90 100
ETVQVIYDEK EVSLREILLY YFRVIDPLSI NQQGNDRGRQ YRTGIYYQDE
110 120 130 140 150
ADLPAIYTVV QEQERMLGRK IAVEVEQLRH YILAEDYHQD YLRKNPSGYC
160 170 180 190 200
HIDVTDADKP LIDAANYEKP SQEVLKASLS EESYRVTQEA ATEAPFTNAY
210 220 230 240 250
DQTFEEGIYV DITTGEPLFF AKDKFASGCG WPSFSRPISK ELIHYYKDLS
260 270 280 290 300
HGMERIEVRS RSGSAHLGHV FTDGPRELGG LRYCINSASL RFVAKDEMEK
310
AGYGYLLPYL NK
Length:312
Mass (Da):35,703
Last modified:March 15, 2005 - v1
Checksum:i6F3873FCE9C1F6E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005672 Genomic DNA. Translation: AAK75457.1.
PIRiH95157.
RefSeqiWP_000818207.1. NZ_AKVY01000001.1.

Genome annotation databases

EnsemblBacteriaiAAK75457; AAK75457; SP_1359.
KEGGispn:SP_1359.
PATRICi19707119. VBIStrPne105772_1402.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005672 Genomic DNA. Translation: AAK75457.1.
PIRiH95157.
RefSeqiWP_000818207.1. NZ_AKVY01000001.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3E0MX-ray2.40A/B/C/D1-312[»]
ProteinModelPortaliP0A3Q9.
SMRiP0A3Q9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi170187.SpneT_02001016.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK75457; AAK75457; SP_1359.
KEGGispn:SP_1359.
PATRICi19707119. VBIStrPne105772_1402.

Phylogenomic databases

eggNOGiENOG4105E0X. Bacteria.
COG0225. LUCA.
COG0229. LUCA.
HOGENOMiHOG000243423.
KOiK12267.
OMAiTEESYRV.

Miscellaneous databases

EvolutionaryTraceiP0A3Q9.

Family and domain databases

Gene3Di2.170.150.20. 1 hit.
3.30.1060.10. 1 hit.
HAMAPiMF_01401. MsrA. 1 hit.
MF_01400. MsrB. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
IPR002579. Met_Sox_Rdtase_MsrB.
IPR011057. Mss4-like.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 2 hits.
PfamiPF01625. PMSR. 1 hit.
PF01641. SelR. 1 hit.
[Graphical view]
SUPFAMiSSF51316. SSF51316. 1 hit.
SSF55068. SSF55068. 1 hit.
TIGRFAMsiTIGR00401. msrA. 1 hit.
TIGR00357. TIGR00357. 1 hit.
PROSITEiPS51790. MSRB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSAB1_STRPN
AccessioniPrimary (citable) accession number: P0A3Q9
Secondary accession number(s): P35593
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: November 2, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Multifunctional enzyme

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.