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Protein

Methylglyoxal synthase

Gene

mgsA

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Glycerone phosphate = methylglyoxal + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei65 – 651By similarity

GO - Molecular functioni

  1. methylglyoxal synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. methylglyoxal biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Names & Taxonomyi

Protein namesi
Recommended name:
Methylglyoxal synthase (EC:4.2.3.3)
Short name:
MGS
Gene namesi
Name:mgsA
Ordered Locus Names:BRA1048, BS1330_II1040
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000007104 Componenti: Chromosome II UP000000824 Componenti: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 125125Methylglyoxal synthasePRO_0000178618Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi204722.BRA1048.

Structurei

3D structure databases

ProteinModelPortaliP0A3Q3.
SMRiP0A3Q3. Positions 1-124.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methylglyoxal synthase family.Curated

Phylogenomic databases

eggNOGiCOG1803.
HOGENOMiHOG000283729.
KOiK01734.
OMAiEPQPHDP.
OrthoDBiEOG644ZN1.

Family and domain databases

Gene3Di3.40.50.1380. 1 hit.
HAMAPiMF_00549. Methylglyoxal_synth.
InterProiIPR004363. Methylgl_synth.
IPR018148. Methylglyoxal_synth_AS.
IPR011607. MGS-like_dom.
[Graphical view]
PfamiPF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF006614. Methylglyox_syn. 1 hit.
SMARTiSM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
TIGRFAMsiTIGR00160. MGSA. 1 hit.
PROSITEiPS01335. METHYLGLYOXAL_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A3Q3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQRLRIALI AHDQKKDDMV AFARAHEQAL SRYDIVATGT TGGLIQDACP
60 70 80 90 100
SLNIHRVKSG PLGGDQQIGA MIAEGTVEVL IFFIDPLSPL PHDVDVKALT
110 120
RLGSVYDIPM ALNRATAEKL VRALD
Length:125
Mass (Da):13,546
Last modified:March 15, 2005 - v1
Checksum:iC8C2734C455C9060
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014292 Genomic DNA. Translation: AAN34215.1.
CP002998 Genomic DNA. Translation: AEM20492.1.
RefSeqiNP_700210.1. NC_004311.2.
YP_005614718.1. NC_017250.1.

Genome annotation databases

EnsemblBacteriaiAAN34215; AAN34215; BRA1048.
AEM20492; AEM20492; BS1330_II1040.
KEGGibms:BRA1048.
bsi:BS1330_II1040.
PATRICi17794931. VBIBruSui107850_3273.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014292 Genomic DNA. Translation: AAN34215.1.
CP002998 Genomic DNA. Translation: AEM20492.1.
RefSeqiNP_700210.1. NC_004311.2.
YP_005614718.1. NC_017250.1.

3D structure databases

ProteinModelPortaliP0A3Q3.
SMRiP0A3Q3. Positions 1-124.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi204722.BRA1048.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN34215; AAN34215; BRA1048.
AEM20492; AEM20492; BS1330_II1040.
KEGGibms:BRA1048.
bsi:BS1330_II1040.
PATRICi17794931. VBIBruSui107850_3273.

Phylogenomic databases

eggNOGiCOG1803.
HOGENOMiHOG000283729.
KOiK01734.
OMAiEPQPHDP.
OrthoDBiEOG644ZN1.

Family and domain databases

Gene3Di3.40.50.1380. 1 hit.
HAMAPiMF_00549. Methylglyoxal_synth.
InterProiIPR004363. Methylgl_synth.
IPR018148. Methylglyoxal_synth_AS.
IPR011607. MGS-like_dom.
[Graphical view]
PfamiPF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF006614. Methylglyox_syn. 1 hit.
SMARTiSM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
TIGRFAMsiTIGR00160. MGSA. 1 hit.
PROSITEiPS01335. METHYLGLYOXAL_SYNTH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiMGSA_BRUSU
AccessioniPrimary (citable) accession number: P0A3Q3
Secondary accession number(s): G0KE54, Q44615
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: April 1, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.