P0A3Q2 (MGSA_BRUME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Methylglyoxal synthase
Short name=MGS
EC=4.2.3.3

Gene names

Name:	mgsA
Ordered Locus Names:	BMEII0252

Organism

Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]

Taxonomic identifier

224914 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella melitensis › Brucella melitensis bv. 1

Protein attributes

Sequence length	125 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Glycerone phosphate = methylglyoxal + phosphate. HAMAP-Rule MF_00549
Sequence similarities	Belongs to the methylglyoxal synthase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	methylglyoxal biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	methylglyoxal synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 125	125	Methylglyoxal synthase HAMAP-Rule MF_00549		PRO_0000178617
Sites
	Active site	65	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0A3Q2 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: C8C2734C455C9060	FASTA	125	13,546
	10 20 30 40 50 60 MTQRLRIALI AHDQKKDDMV AFARAHEQAL SRYDIVATGT TGGLIQDACP SLNIHRVKSG 70 80 90 100 110 120 PLGGDQQIGA MIAEGTVEVL IFFIDPLSPL PHDVDVKALT RLGSVYDIPM ALNRATAEKL VRALD

References

[1]

"The genome sequence of the facultative intracellular pathogen Brucella melitensis." DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E. , Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R. Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE008918 Genomic DNA. Translation: AAL53493.1.
PIR	AB3541.
RefSeq	NP_541229.1. NC_003318.1.
3D structure databases
ProteinModelPortal	P0A3Q2.
SMR	P0A3Q2. Positions 1-124.
ModBase	Search...
Protein-protein interaction databases
STRING	224914.BMEII0252.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL53493; AAL53493; BMEII0252.
GeneID	1198023.
KEGG	bme:BMEII0252.
PATRIC	17800681. VBIBruMel146950_2671.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000283729.
KO	K01734.
OMA	EPQPHDP.
ProtClustDB	PRK05234.
Family and domain databases
Gene3D	3.40.50.1380. 1 hit.
HAMAP	MF_00549. Methylglyoxal_synth.
InterPro	IPR004363. Methylgl_synth. IPR018148. Methylglyoxal_synth_AS. IPR011607. MGS-like_dom. [Graphical view]
Pfam	PF02142. MGS. 1 hit. [Graphical view]
PIRSF	PIRSF006614. Methylglyox_syn. 1 hit.
SMART	SM00851. MGS. 1 hit. [Graphical view]
SUPFAM	SSF52335. MGS-like_dom. 1 hit.
TIGRFAMs	TIGR00160. MGSA. 1 hit.
PROSITE	PS01335. METHYLGLYOXAL_SYNTH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MGSA_BRUME

Accession

Primary (citable) accession number: P0A3Q2
Secondary accession number(s): Q44615

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	March 15, 2005
Last modified:	May 1, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program