P0A3Q1 (MALQ_STRR6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
4-alpha-glucanotransferase
EC=2.4.1.25

Alternative name(s):
Amylomaltase
Disproportionating enzyme
Short name=D-enzyme

Gene names

Name:	malQ
Synonyms:	malM
Ordered Locus Names:	spr1917

Organism

Streptococcus pneumoniae (strain ATCC BAA-255 / R6)

Taxonomic identifier

171101 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	505 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Transfers a segment of a (1->4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1->4)-alpha-D-glucan.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the disproportionating enzyme family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	4-alpha-glucanotransferase activity Inferred from electronic annotation. Source: EC cation binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 505	505	4-alpha-glucanotransferase		PRO_0000170130

Sequences

	Sequence		Length	Mass (Da)
	P0A3Q1 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: D4529A000A6D01A5	FASTA	505	58,076
	10 20 30 40 50 60 MKKRQSGVLM HISSLPGAYG IGSFGQSAYD FVDFLVRTKQ RYWQILPLGA TSYGDSPYQS 70 80 90 100 110 120 FSAFAGNTHF IDLDILVEQG LLEASDLEGV DFGSDASEVD YAKIYYARRP LLEKAVKRFF 130 140 150 160 170 180 EVGDVKDFEK FAQDNQSWLE LFAEYMAIKE YFDNLAWTEW PDADARARKA SALESYREQL 190 200 210 220 230 240 ADKLVYHRVT QYFFFQQWLK LKAYANDNHI EIVGDMPIYV AEDSSDMWAN PHLFKTDVNG 250 260 270 280 290 300 KATCIAGCPP DEFSVTGQLW GNPIYDWEAM DKDGYKWWIE RLRESFKIYD IVRIDHFRGF 310 320 330 340 350 360 ESYWEIPAGS DTAAPGEWVK GPGYKLFAAV KEELGELNII AEDLGFMTDE VIELRERTGF 370 380 390 400 410 420 PGMKILQFAF NPEDESIDSP HLAPANSVMY TGTHDNNTVL GWYRNEIDDA TREYMARYTN 430 440 450 460 470 480 RKEYETVVHA MLRTVFSSVS FMAIATMQDL LELDEAARMN FPSTLGGNWS WRMTEDQLTP 490 500 AVEEGLLDLT TIYRRINENL VDLKK

References

[1]

"Genome of the bacterium Streptococcus pneumoniae strain R6." Hoskins J., Alborn W.E. Jr., Arnold J., Blaszczak L.C., Burgett S., DeHoff B.S., Estrem S.T., Fritz L., Fu D.-J., Fuller W., Geringer C., Gilmour R., Glass J.S., Khoja H., Kraft A.R., Lagace R.E., LeBlanc D.J., Lee L.N. , Lefkowitz E.J., Lu J., Matsushima P., McAhren S.M., McHenney M., McLeaster K., Mundy C.W., Nicas T.I., Norris F.H., O'Gara M., Peery R.B., Robertson G.T., Rockey P., Sun P.-M., Winkler M.E., Yang Y., Young-Bellido M., Zhao G., Zook C.A., Baltz R.H., Jaskunas S.R., Rosteck P.R. Jr., Skatrud P.L., Glass J.I. J. Bacteriol. 183:5709-5717(2001) [PubMed: 11544234] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-255 / R6.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE007317 Genomic DNA. Translation: AAL00719.1.
PIR	B98111.
RefSeq	NP_359508.1. NC_003098.1.
3D structure databases
ProteinModelPortal	P0A3Q1.
ModBase	Search...
Protein-protein interaction databases
STRING	P0A3Q1.
Protein family/group databases
CAZy	GH77. Glycoside Hydrolase Family 77.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000014605; EBSTRP00000014001; EBSTRG00000014605.
GeneID	934839.
GenomeReviews	Gene locus spr1917 in contig AE007317_GR.
KEGG	spr:spr1917.
PATRIC	19704006. VBIStrPne107296_2066.
Phylogenomic databases
eggNOG	COG1640.
GeneTree	EBGT00050000028126.
HOGENOM	HBG704085.
OMA	WGNPLYN.
PhylomeDB	P0A3Q1.
ProtClustDB	PRK14508.
Enzyme and pathway databases
BioCyc	SPNE171101:SPR1917-MONOMER.
Family and domain databases
InterPro	IPR003385. Glyco_hydro_77. IPR013781. Glyco_hydro_subgr_catalytic. IPR017853. Glycoside_hydrolase_SF. [Graphical view]
Gene3D	G3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit.
KO	K00705.
Pfam	PF02446. Glyco_hydro_77. 1 hit. [Graphical view]
SUPFAM	SSF51445. Glyco_hydro_cat. 1 hit.
TIGRFAMs	TIGR00217. MalQ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MALQ_STRR6

Accession

Primary (citable) accession number: P0A3Q1
Secondary accession number(s): P29851

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	March 15, 2005
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program