ID   MALQ_STRPN              Reviewed;         505 AA.
AC   P0A3Q0; P29851;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   27-MAR-2024, entry version 101.
DE   RecName: Full=4-alpha-glucanotransferase;
DE            EC=2.4.1.25;
DE   AltName: Full=Amylomaltase;
DE   AltName: Full=Disproportionating enzyme;
DE            Short=D-enzyme;
GN   Name=malQ; Synonyms=malM; OrderedLocusNames=SP_2107;
OS   Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=170187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6297760; DOI=10.1016/0092-8674(82)90126-x;
RA   Lacks S.A., Dunn J.J., Greenberg B.;
RT   "Identification of base mismatches recognized by the heteroduplex-DNA-
RT   repair system of Streptococcus pneumoniae.";
RL   Cell 31:327-336(1982).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA   Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA   Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Transfers a segment of a (1->4)-alpha-D-glucan to a new
CC         position in an acceptor, which may be glucose or a (1->4)-alpha-D-
CC         glucan.; EC=2.4.1.25;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the disproportionating enzyme family.
CC       {ECO:0000305}.
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DR   EMBL; J01796; AAA26923.1; -; Genomic_DNA.
DR   EMBL; AE005672; AAK76166.1; -; Genomic_DNA.
DR   PIR; E95246; E95246.
DR   RefSeq; WP_000747291.1; NZ_AKVY01000001.1.
DR   AlphaFoldDB; P0A3Q0; -.
DR   SMR; P0A3Q0; -.
DR   CAZy; GH77; Glycoside Hydrolase Family 77.
DR   PaxDb; 170187-SP_2107; -.
DR   EnsemblBacteria; AAK76166; AAK76166; SP_2107.
DR   GeneID; 66807186; -.
DR   KEGG; spn:SP_2107; -.
DR   eggNOG; COG1640; Bacteria.
DR   PhylomeDB; P0A3Q0; -.
DR   BioCyc; SPNE170187:G1FZB-2195-MONOMER; -.
DR   Proteomes; UP000000585; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004134; F:4-alpha-glucanotransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0102500; F:beta-maltose 4-alpha-glucanotransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   InterPro; IPR003385; Glyco_hydro_77.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   NCBIfam; TIGR00217; malQ; 1.
DR   PANTHER; PTHR32438; 4-ALPHA-GLUCANOTRANSFERASE DPE1, CHLOROPLASTIC/AMYLOPLASTIC; 1.
DR   PANTHER; PTHR32438:SF5; 4-ALPHA-GLUCANOTRANSFERASE DPE1, CHLOROPLASTIC_AMYLOPLASTIC; 1.
DR   Pfam; PF02446; Glyco_hydro_77; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Cytoplasm; Glycosyltransferase;
KW   Reference proteome; Transferase.
FT   CHAIN           1..505
FT                   /note="4-alpha-glucanotransferase"
FT                   /id="PRO_0000170129"
SQ   SEQUENCE   505 AA;  58076 MW;  D4529A000A6D01A5 CRC64;
     MKKRQSGVLM HISSLPGAYG IGSFGQSAYD FVDFLVRTKQ RYWQILPLGA TSYGDSPYQS
     FSAFAGNTHF IDLDILVEQG LLEASDLEGV DFGSDASEVD YAKIYYARRP LLEKAVKRFF
     EVGDVKDFEK FAQDNQSWLE LFAEYMAIKE YFDNLAWTEW PDADARARKA SALESYREQL
     ADKLVYHRVT QYFFFQQWLK LKAYANDNHI EIVGDMPIYV AEDSSDMWAN PHLFKTDVNG
     KATCIAGCPP DEFSVTGQLW GNPIYDWEAM DKDGYKWWIE RLRESFKIYD IVRIDHFRGF
     ESYWEIPAGS DTAAPGEWVK GPGYKLFAAV KEELGELNII AEDLGFMTDE VIELRERTGF
     PGMKILQFAF NPEDESIDSP HLAPANSVMY TGTHDNNTVL GWYRNEIDDA TREYMARYTN
     RKEYETVVHA MLRTVFSSVS FMAIATMQDL LELDEAARMN FPSTLGGNWS WRMTEDQLTP
     AVEEGLLDLT TIYRRINENL VDLKK
//