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P0A3P9

- LUXS_STRP8

UniProt

P0A3P9 - LUXS_STRP8

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Protein
S-ribosylhomocysteine lyase
Gene
luxS, spyM18_1653
Organism
Streptococcus pyogenes serotype M18 (strain MGAS8232)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD) By similarity.UniRule annotation

Catalytic activityi

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione.UniRule annotation

Cofactori

Binds 1 iron ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi57 – 571Iron By similarity
Metal bindingi61 – 611Iron By similarity
Metal bindingi127 – 1271Iron By similarity

GO - Molecular functioni

  1. S-ribosylhomocysteine lyase activity Source: UniProtKB-HAMAP
  2. iron ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. quorum sensing Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Autoinducer synthesis, Quorum sensing

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciSPYO186103:GHJG-1429-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
S-ribosylhomocysteine lyase (EC:4.4.1.21)
Alternative name(s):
AI-2 synthesis protein
Autoinducer-2 production protein LuxS
Gene namesi
Name:luxS
Ordered Locus Names:spyM18_1653
OrganismiStreptococcus pyogenes serotype M18 (strain MGAS8232)
Taxonomic identifieri186103 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000820: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 160160S-ribosylhomocysteine lyaseUniRule annotation
PRO_0000172271Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi186103.spyM18_1653.

Structurei

3D structure databases

ProteinModelPortaliP0A3P9.

Family & Domainsi

Sequence similaritiesi

Belongs to the LuxS family.

Phylogenomic databases

HOGENOMiHOG000040372.
KOiK07173.
OrthoDBiEOG68WRBM.

Family and domain databases

Gene3Di3.30.1360.80. 1 hit.
HAMAPiMF_00091. LuxS.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR003815. S-ribosylhomocysteinase.
[Graphical view]
PfamiPF02664. LuxS. 1 hit.
[Graphical view]
PIRSFiPIRSF006160. AI2. 1 hit.
PRINTSiPR01487. LUXSPROTEIN.
ProDomiPD013172. S-ribosylhomocysteinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF63411. SSF63411. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A3P9-1 [UniParc]FASTAAdd to Basket

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MTKEVIVESF ELDHTIVKAP YVRLISEEFG PKGDRITNFD VRLVQPNQNS    50
IETAGLHTIE HLLAKLIRQR IDGMIDCSPF GCRTGFHLIM WGKHSSTDIA 100
KVIKSSLEEI ATGITWEDVP GTTLESCGNY KDHSLFAAKE WAQLIIDQGI 150
SDDPFSRHVI 160
Length:160
Mass (Da):17,979
Last modified:March 15, 2005 - v1
Checksum:iA45592396C76BD21
GO

Sequence cautioni

The sequence AAL98199.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009949 Genomic DNA. Translation: AAL98199.1. Different initiation.
RefSeqiNP_607700.1. NC_003485.1.

Genome annotation databases

EnsemblBacteriaiAAL98199; AAL98199; spyM18_1653.
GeneIDi994586.
KEGGispm:spyM18_1653.
PATRICi19749814. VBIStrPyo4396_1481.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009949 Genomic DNA. Translation: AAL98199.1 . Different initiation.
RefSeqi NP_607700.1. NC_003485.1.

3D structure databases

ProteinModelPortali P0A3P9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 186103.spyM18_1653.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL98199 ; AAL98199 ; spyM18_1653 .
GeneIDi 994586.
KEGGi spm:spyM18_1653.
PATRICi 19749814. VBIStrPyo4396_1481.

Phylogenomic databases

HOGENOMi HOG000040372.
KOi K07173.
OrthoDBi EOG68WRBM.

Enzyme and pathway databases

BioCyci SPYO186103:GHJG-1429-MONOMER.

Family and domain databases

Gene3Di 3.30.1360.80. 1 hit.
HAMAPi MF_00091. LuxS.
InterProi IPR011249. Metalloenz_LuxS/M16.
IPR003815. S-ribosylhomocysteinase.
[Graphical view ]
Pfami PF02664. LuxS. 1 hit.
[Graphical view ]
PIRSFi PIRSF006160. AI2. 1 hit.
PRINTSi PR01487. LUXSPROTEIN.
ProDomi PD013172. S-ribosylhomocysteinase. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF63411. SSF63411. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks."
    Smoot J.C., Barbian K.D., Van Gompel J.J., Smoot L.M., Chaussee M.S., Sylva G.L., Sturdevant D.E., Ricklefs S.M., Porcella S.F., Parkins L.D., Beres S.B., Campbell D.S., Smith T.M., Zhang Q., Kapur V., Daly J.A., Veasy L.G., Musser J.M.
    Proc. Natl. Acad. Sci. U.S.A. 99:4668-4673(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MGAS8232.

Entry informationi

Entry nameiLUXS_STRP8
AccessioniPrimary (citable) accession number: P0A3P9
Secondary accession number(s): Q99YL7, Q9EVB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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