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Protein

L-lactate dehydrogenase

Gene

ldh

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (ldh)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei94 – 941SubstrateBy similarity
Binding sitei126 – 1261NAD or substrateBy similarity
Binding sitei157 – 1571SubstrateBy similarity
Active sitei181 – 1811Proton acceptorBy similarity
Binding sitei235 – 2351SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi16 – 4631NADBy similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSPNE170187:GHGN-1225-MONOMER.
UniPathwayiUPA00554; UER00611.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenase (EC:1.1.1.27)
Short name:
L-LDH
Gene namesi
Name:ldh
Ordered Locus Names:SP_1220
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000585 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 328327L-lactate dehydrogenasePRO_0000168397Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei226 – 2261PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi170187.SP_1220.

Structurei

3D structure databases

ProteinModelPortaliP0A3M9.
SMRiP0A3M9. Positions 3-317.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.Curated

Phylogenomic databases

eggNOGiENOG4105C80. Bacteria.
COG0039. LUCA.
HOGENOMiHOG000213793.
KOiK00016.
OMAiMDLMQTA.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiPS00064. L_LDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A3M9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSTKQHKKV ILVGDGAVGS SYAFALVNQG IAQELGIIEI PQLHEKAVGD
60 70 80 90 100
ALDLSHALAF TSPKKIYAAQ YSDCADADLV VITAGAPQKP GETRLDLVGK
110 120 130 140 150
NLAINKSIVT QVVESGFKGI FLVAANPVDV LTYSTWKFSG FPKERVIGSG
160 170 180 190 200
TSLDSARFRQ ALAEKLDVDA RSVHAYIMGE HGDSEFAVWS HANIAGVNLE
210 220 230 240 250
EFLKDTQNVQ EAELIELFEG VRDAAYTIIN KKGATYYGIA VALARITKAI
260 270 280 290 300
LDDENAVLPL SVFQEGQYGV ENVFIGQPAV VGAHGIVRPV NIPLNDAETQ
310 320
KMQASAKELQ AIIDEAWKNP EFQEASKN
Length:328
Mass (Da):35,355
Last modified:January 23, 2007 - v2
Checksum:i617AAE9603D503B7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti106 – 1061K → R in AAL30970 (PubMed:12399507).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005672 Genomic DNA. Translation: AAK75326.1.
AJ005815 Genomic DNA. Translation: CAA06714.1.
AF436728 Genomic DNA. Translation: AAL30965.1.
AF436729 Genomic DNA. Translation: AAL30966.1.
AF436730 Genomic DNA. Translation: AAL30967.1.
AF436731 Genomic DNA. Translation: AAL30968.1.
AF436732 Genomic DNA. Translation: AAL30969.1.
AF436733 Genomic DNA. Translation: AAL30970.1.
AF436734 Genomic DNA. Translation: AAL30971.1.
AF436735 Genomic DNA. Translation: AAL30972.1.
AF436736 Genomic DNA. Translation: AAL30973.1.
AF436737 Genomic DNA. Translation: AAL30974.1.
AF436738 Genomic DNA. Translation: AAL30975.1.
AF436739 Genomic DNA. Translation: AAL30976.1.
AF436740 Genomic DNA. Translation: AAL30977.1.
PIRiE95141.
RefSeqiWP_000204727.1. NZ_AKVY01000001.1.

Genome annotation databases

EnsemblBacteriaiAAK75326; AAK75326; SP_1220.
KEGGispn:SP_1220.
PATRICi19706833. VBIStrPne105772_1261.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005672 Genomic DNA. Translation: AAK75326.1.
AJ005815 Genomic DNA. Translation: CAA06714.1.
AF436728 Genomic DNA. Translation: AAL30965.1.
AF436729 Genomic DNA. Translation: AAL30966.1.
AF436730 Genomic DNA. Translation: AAL30967.1.
AF436731 Genomic DNA. Translation: AAL30968.1.
AF436732 Genomic DNA. Translation: AAL30969.1.
AF436733 Genomic DNA. Translation: AAL30970.1.
AF436734 Genomic DNA. Translation: AAL30971.1.
AF436735 Genomic DNA. Translation: AAL30972.1.
AF436736 Genomic DNA. Translation: AAL30973.1.
AF436737 Genomic DNA. Translation: AAL30974.1.
AF436738 Genomic DNA. Translation: AAL30975.1.
AF436739 Genomic DNA. Translation: AAL30976.1.
AF436740 Genomic DNA. Translation: AAL30977.1.
PIRiE95141.
RefSeqiWP_000204727.1. NZ_AKVY01000001.1.

3D structure databases

ProteinModelPortaliP0A3M9.
SMRiP0A3M9. Positions 3-317.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi170187.SP_1220.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK75326; AAK75326; SP_1220.
KEGGispn:SP_1220.
PATRICi19706833. VBIStrPne105772_1261.

Phylogenomic databases

eggNOGiENOG4105C80. Bacteria.
COG0039. LUCA.
HOGENOMiHOG000213793.
KOiK00016.
OMAiMDLMQTA.

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611.
BioCyciSPNE170187:GHGN-1225-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiPS00064. L_LDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLDH_STRPN
AccessioniPrimary (citable) accession number: P0A3M9
Secondary accession number(s): O33734
, Q8VLI8, Q8VVY0, Q9R868
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.