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Protein

L-lactate dehydrogenase

Gene

ldh

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (ldh)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei94SubstrateBy similarity1
Binding sitei126NAD or substrateBy similarity1
Binding sitei157SubstrateBy similarity1
Active sitei181Proton acceptorBy similarity1
Binding sitei235SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 46NADBy similarityAdd BLAST31

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenase (EC:1.1.1.27)
Short name:
L-LDH
Gene namesi
Name:ldh
Ordered Locus Names:SP_1220
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000585 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001683972 – 328L-lactate dehydrogenaseAdd BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei226PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP0A3M9

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP0A3M9
SMRiP0A3M9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.Curated

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
HOGENOMiHOG000213793
KOiK00016
OMAiMDLMQTA

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A3M9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSTKQHKKV ILVGDGAVGS SYAFALVNQG IAQELGIIEI PQLHEKAVGD
60 70 80 90 100
ALDLSHALAF TSPKKIYAAQ YSDCADADLV VITAGAPQKP GETRLDLVGK
110 120 130 140 150
NLAINKSIVT QVVESGFKGI FLVAANPVDV LTYSTWKFSG FPKERVIGSG
160 170 180 190 200
TSLDSARFRQ ALAEKLDVDA RSVHAYIMGE HGDSEFAVWS HANIAGVNLE
210 220 230 240 250
EFLKDTQNVQ EAELIELFEG VRDAAYTIIN KKGATYYGIA VALARITKAI
260 270 280 290 300
LDDENAVLPL SVFQEGQYGV ENVFIGQPAV VGAHGIVRPV NIPLNDAETQ
310 320
KMQASAKELQ AIIDEAWKNP EFQEASKN
Length:328
Mass (Da):35,355
Last modified:January 23, 2007 - v2
Checksum:i617AAE9603D503B7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti106K → R in AAL30970 (PubMed:12399507).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005672 Genomic DNA Translation: AAK75326.1
AJ005815 Genomic DNA Translation: CAA06714.1
AF436728 Genomic DNA Translation: AAL30965.1
AF436729 Genomic DNA Translation: AAL30966.1
AF436730 Genomic DNA Translation: AAL30967.1
AF436731 Genomic DNA Translation: AAL30968.1
AF436732 Genomic DNA Translation: AAL30969.1
AF436733 Genomic DNA Translation: AAL30970.1
AF436734 Genomic DNA Translation: AAL30971.1
AF436735 Genomic DNA Translation: AAL30972.1
AF436736 Genomic DNA Translation: AAL30973.1
AF436737 Genomic DNA Translation: AAL30974.1
AF436738 Genomic DNA Translation: AAL30975.1
AF436739 Genomic DNA Translation: AAL30976.1
AF436740 Genomic DNA Translation: AAL30977.1
PIRiE95141
RefSeqiWP_000204727.1, NZ_AKVY01000001.1

Genome annotation databases

EnsemblBacteriaiAAK75326; AAK75326; SP_1220
KEGGispn:SP_1220

Similar proteinsi

Entry informationi

Entry nameiLDH_STRPN
AccessioniPrimary (citable) accession number: P0A3M9
Secondary accession number(s): O33734
, Q8VLI8, Q8VVY0, Q9R868
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health