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Protein

Penicillin-binding protein 2B

Gene

penA

Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Penicillin-binding protein 2B
Gene namesi
Name:penA
Synonyms:pbp2b
Ordered Locus Names:spr1517
OrganismiStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Taxonomic identifieri171101 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000586 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

DrugBankiDB00415. Ampicillin.
DB08795. Azidocillin.
DB01140. Cefadroxil.
DB00456. Cefalotin.
DB01066. Cefditoren.
DB00493. Cefotaxime.
DB01331. Cefoxitin.
DB01212. Ceftriaxone.
DB00567. Cephalexin.
DB00485. Dicloxacillin.
DB00739. Hetacillin.
DB01603. Meticillin.
DB00607. Nafcillin.
DB00713. Oxacillin.
DB00319. Piperacillin.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001954561 – 680Penicillin-binding protein 2BAdd BLAST680

Interactioni

Protein-protein interaction databases

STRINGi171101.spr1517.

Structurei

Secondary structure

1680
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi53 – 58Combined sources6
Beta strandi72 – 83Combined sources12
Helixi90 – 101Combined sources12
Helixi113 – 120Combined sources8
Helixi124 – 131Combined sources8
Helixi150 – 160Combined sources11
Helixi171 – 182Combined sources12
Helixi200 – 208Combined sources9
Helixi209 – 211Combined sources3
Beta strandi216 – 225Combined sources10
Helixi231 – 234Combined sources4
Turni240 – 242Combined sources3
Helixi246 – 255Combined sources10
Beta strandi264 – 266Combined sources3
Helixi267 – 271Combined sources5
Helixi273 – 276Combined sources4
Beta strandi277 – 284Combined sources8
Beta strandi293 – 295Combined sources3
Beta strandi307 – 311Combined sources5
Helixi314 – 333Combined sources20
Turni334 – 339Combined sources6
Beta strandi342 – 348Combined sources7
Turni350 – 352Combined sources3
Beta strandi354 – 363Combined sources10
Turni365 – 367Combined sources3
Beta strandi370 – 372Combined sources3
Helixi376 – 379Combined sources4
Helixi385 – 388Combined sources4
Helixi389 – 398Combined sources10
Beta strandi407 – 410Combined sources4
Turni424 – 428Combined sources5
Beta strandi431 – 435Combined sources5
Helixi436 – 441Combined sources6
Helixi445 – 456Combined sources12
Helixi468 – 470Combined sources3
Helixi471 – 484Combined sources14
Turni485 – 488Combined sources4
Beta strandi494 – 496Combined sources3
Helixi509 – 515Combined sources7
Turni516 – 518Combined sources3
Beta strandi519 – 523Combined sources5
Helixi525 – 536Combined sources12
Beta strandi539 – 542Combined sources4
Beta strandi545 – 553Combined sources9
Beta strandi557 – 565Combined sources9
Beta strandi570 – 573Combined sources4
Helixi578 – 593Combined sources16
Helixi602 – 605Combined sources4
Beta strandi613 – 616Combined sources4
Beta strandi619 – 621Combined sources3
Beta strandi629 – 631Combined sources3
Beta strandi634 – 638Combined sources5
Beta strandi640 – 642Combined sources3
Beta strandi645 – 650Combined sources6
Beta strandi653 – 655Combined sources3
Helixi661 – 674Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WADX-ray2.18A/B/C1-680[»]
2WAEX-ray2.26A1-680[»]
2WAFX-ray3.29A1-680[»]
ProteinModelPortaliP0A3M6.
SMRiP0A3M6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A3M6.

Family & Domainsi

Sequence similaritiesi

Belongs to the transpeptidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107RF6. Bacteria.
COG0768. LUCA.
HOGENOMiHOG000013470.
KOiK00687.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF03717. PBP_dimer. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56519. SSF56519. 2 hits.
SSF56601. SSF56601. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A3M6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKFNSHSIP IRLNLLFSIV ILLFMTIIGR LLYMQVLNKD FYEKKLASAS
60 70 80 90 100
QTKITSSSAR GEIYDASGKP LVENTLKQVV SFTRSNKMTA TDLKETAKKL
110 120 130 140 150
LTYVSISSPN LTERQLADYY LADPEIYKKI VEALPSEKRL DSDGNRLSES
160 170 180 190 200
ELYNNAVDSV QTSQLNYTED EKKEIYLFSQ LNAVGNFATG TIATDPLNDS
210 220 230 240 250
QVAVIASISK EMPGISISTS WDRKVLETSL SSIVGSVSSE KAGLPAEEAE
260 270 280 290 300
AYLKKGYSLN DRVGTSYLEK QYEETLQGKR SVKEIHLDKY GNMESVDTIE
310 320 330 340 350
EGSKGNNIKL TIDLAFQDSV DALLKSYFNS ELENGGAKYS EGVYAVALNP
360 370 380 390 400
KTGAVLSMSG IKHDLKTGEL TPDSLGTVTN VFVPGSVVKA ATISSGWENG
410 420 430 440 450
VLSGNQTLTD QSIVFQGSAP INSWYTQAYG SFPITAVQAL EYSSNTYMVQ
460 470 480 490 500
TALGLMGQTY QPNMFVGTSN LESAMEKLRS TFGEYGLGTA TGIDLPDEST
510 520 530 540 550
GFVPKEYSFA NYITNAFGQF DNYTPMQLAQ YVATIANNGV RVAPRIVEGI
560 570 580 590 600
YGNNDKGGLG DLIQQLQPTE MNKVNISDSD MSILHQGFYQ VAHGTSGLTT
610 620 630 640 650
GRAFSNGALV SISGKTGTAE SYVADGQQAT NTNAVAYAPS DNPQIAVAVV
660 670 680
FPHNTNLTNG VGPSIARDII NLYQKYHPMN
Length:680
Mass (Da):73,873
Last modified:March 15, 2005 - v1
Checksum:i56BF2C1AA9B54C3B
GO

Sequence cautioni

The sequence AAL00321 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37L → F in CAA34154 (PubMed:2798106).Curated1
Sequence conflicti115 – 117QLA → AG in CAA34154 (PubMed:2798106).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16022 Genomic DNA. Translation: CAA34154.1.
AE007317 Genomic DNA. Translation: AAL00321.1. Different initiation.
X13137 Genomic DNA. Translation: CAA31527.1.
PIRiD98061.
S06000.
RefSeqiNP_359110.1. NC_003098.1.
WP_001829432.1. NC_003098.1.

Genome annotation databases

EnsemblBacteriaiAAL00321; AAL00321; spr1517.
GeneIDi933948.
KEGGispr:spr1517.
PATRICi19703047. VBIStrPne107296_1637.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16022 Genomic DNA. Translation: CAA34154.1.
AE007317 Genomic DNA. Translation: AAL00321.1. Different initiation.
X13137 Genomic DNA. Translation: CAA31527.1.
PIRiD98061.
S06000.
RefSeqiNP_359110.1. NC_003098.1.
WP_001829432.1. NC_003098.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WADX-ray2.18A/B/C1-680[»]
2WAEX-ray2.26A1-680[»]
2WAFX-ray3.29A1-680[»]
ProteinModelPortaliP0A3M6.
SMRiP0A3M6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi171101.spr1517.

Chemistry databases

DrugBankiDB00415. Ampicillin.
DB08795. Azidocillin.
DB01140. Cefadroxil.
DB00456. Cefalotin.
DB01066. Cefditoren.
DB00493. Cefotaxime.
DB01331. Cefoxitin.
DB01212. Ceftriaxone.
DB00567. Cephalexin.
DB00485. Dicloxacillin.
DB00739. Hetacillin.
DB01603. Meticillin.
DB00607. Nafcillin.
DB00713. Oxacillin.
DB00319. Piperacillin.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL00321; AAL00321; spr1517.
GeneIDi933948.
KEGGispr:spr1517.
PATRICi19703047. VBIStrPne107296_1637.

Phylogenomic databases

eggNOGiENOG4107RF6. Bacteria.
COG0768. LUCA.
HOGENOMiHOG000013470.
KOiK00687.

Miscellaneous databases

EvolutionaryTraceiP0A3M6.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF03717. PBP_dimer. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56519. SSF56519. 2 hits.
SSF56601. SSF56601. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPBP2_STRR6
AccessioniPrimary (citable) accession number: P0A3M6
Secondary accession number(s): P10524
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: November 30, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.