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P0A3M6

- PBP2_STRR6

UniProt

P0A3M6 - PBP2_STRR6

Protein

Penicillin-binding protein 2B

Gene

penA

Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. penicillin binding Source: InterPro

    GO - Biological processi

    1. peptidoglycan biosynthetic process Source: UniProtKB-KW
    2. regulation of cell shape Source: UniProtKB-KW
    3. response to antibiotic Source: UniProtKB-KW

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciSPNE171101:GJC8-1531-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Penicillin-binding protein 2B
    Gene namesi
    Name:penA
    Synonyms:pbp2b
    Ordered Locus Names:spr1517
    OrganismiStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
    Taxonomic identifieri171101 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000586: Chromosome

    Subcellular locationi

    Cell membrane By similarity; Single-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 680680Penicillin-binding protein 2BPRO_0000195456Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi171101.spr1517.

    Structurei

    Secondary structure

    1
    680
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi53 – 586
    Beta strandi72 – 8312
    Helixi90 – 10112
    Helixi113 – 1208
    Helixi124 – 1318
    Helixi150 – 16011
    Helixi171 – 18212
    Helixi200 – 2089
    Helixi209 – 2113
    Beta strandi216 – 22510
    Helixi231 – 2344
    Turni240 – 2423
    Helixi246 – 25510
    Beta strandi264 – 2663
    Helixi267 – 2715
    Helixi273 – 2764
    Beta strandi277 – 2848
    Beta strandi293 – 2953
    Beta strandi307 – 3115
    Helixi314 – 33320
    Turni334 – 3396
    Beta strandi342 – 3487
    Turni350 – 3523
    Beta strandi354 – 36310
    Turni365 – 3673
    Beta strandi370 – 3723
    Helixi376 – 3794
    Helixi385 – 3884
    Helixi389 – 39810
    Beta strandi407 – 4104
    Turni424 – 4285
    Beta strandi431 – 4355
    Helixi436 – 4416
    Helixi445 – 45612
    Helixi468 – 4703
    Helixi471 – 48414
    Turni485 – 4884
    Beta strandi494 – 4963
    Helixi509 – 5157
    Turni516 – 5183
    Beta strandi519 – 5235
    Helixi525 – 53612
    Beta strandi539 – 5424
    Beta strandi545 – 5539
    Beta strandi557 – 5659
    Beta strandi570 – 5734
    Helixi578 – 59316
    Helixi602 – 6054
    Beta strandi613 – 6164
    Beta strandi619 – 6213
    Beta strandi629 – 6313
    Beta strandi634 – 6385
    Beta strandi640 – 6423
    Beta strandi645 – 6506
    Beta strandi653 – 6553
    Helixi661 – 67414

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2WADX-ray2.18A/B/C1-680[»]
    2WAEX-ray2.26A1-680[»]
    2WAFX-ray3.29A1-680[»]
    ProteinModelPortaliP0A3M6.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP0A3M6.

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 2921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the transpeptidase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0768.
    HOGENOMiHOG000013470.
    KOiK00687.
    OrthoDBiEOG6N0HHV.

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR005311. PBP_dimer.
    IPR001460. PCN-bd_Tpept.
    [Graphical view]
    PfamiPF03717. PBP_dimer. 1 hit.
    PF00905. Transpeptidase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56519. SSF56519. 2 hits.
    SSF56601. SSF56601. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0A3M6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRKFNSHSIP IRLNLLFSIV ILLFMTIIGR LLYMQVLNKD FYEKKLASAS    50
    QTKITSSSAR GEIYDASGKP LVENTLKQVV SFTRSNKMTA TDLKETAKKL 100
    LTYVSISSPN LTERQLADYY LADPEIYKKI VEALPSEKRL DSDGNRLSES 150
    ELYNNAVDSV QTSQLNYTED EKKEIYLFSQ LNAVGNFATG TIATDPLNDS 200
    QVAVIASISK EMPGISISTS WDRKVLETSL SSIVGSVSSE KAGLPAEEAE 250
    AYLKKGYSLN DRVGTSYLEK QYEETLQGKR SVKEIHLDKY GNMESVDTIE 300
    EGSKGNNIKL TIDLAFQDSV DALLKSYFNS ELENGGAKYS EGVYAVALNP 350
    KTGAVLSMSG IKHDLKTGEL TPDSLGTVTN VFVPGSVVKA ATISSGWENG 400
    VLSGNQTLTD QSIVFQGSAP INSWYTQAYG SFPITAVQAL EYSSNTYMVQ 450
    TALGLMGQTY QPNMFVGTSN LESAMEKLRS TFGEYGLGTA TGIDLPDEST 500
    GFVPKEYSFA NYITNAFGQF DNYTPMQLAQ YVATIANNGV RVAPRIVEGI 550
    YGNNDKGGLG DLIQQLQPTE MNKVNISDSD MSILHQGFYQ VAHGTSGLTT 600
    GRAFSNGALV SISGKTGTAE SYVADGQQAT NTNAVAYAPS DNPQIAVAVV 650
    FPHNTNLTNG VGPSIARDII NLYQKYHPMN 680
    Length:680
    Mass (Da):73,873
    Last modified:March 15, 2005 - v1
    Checksum:i56BF2C1AA9B54C3B
    GO

    Sequence cautioni

    The sequence AAL00321.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti37 – 371L → F in CAA34154. (PubMed:2798106)Curated
    Sequence conflicti115 – 1173QLA → AG in CAA34154. (PubMed:2798106)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16022 Genomic DNA. Translation: CAA34154.1.
    AE007317 Genomic DNA. Translation: AAL00321.1. Different initiation.
    X13137 Genomic DNA. Translation: CAA31527.1.
    PIRiD98061.
    S06000.
    RefSeqiNP_359110.1. NC_003098.1.

    Genome annotation databases

    EnsemblBacteriaiAAL00321; AAL00321; spr1517.
    GeneIDi933948.
    KEGGispr:spr1517.
    PATRICi19703047. VBIStrPne107296_1637.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16022 Genomic DNA. Translation: CAA34154.1 .
    AE007317 Genomic DNA. Translation: AAL00321.1 . Different initiation.
    X13137 Genomic DNA. Translation: CAA31527.1 .
    PIRi D98061.
    S06000.
    RefSeqi NP_359110.1. NC_003098.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2WAD X-ray 2.18 A/B/C 1-680 [» ]
    2WAE X-ray 2.26 A 1-680 [» ]
    2WAF X-ray 3.29 A 1-680 [» ]
    ProteinModelPortali P0A3M6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 171101.spr1517.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL00321 ; AAL00321 ; spr1517 .
    GeneIDi 933948.
    KEGGi spr:spr1517.
    PATRICi 19703047. VBIStrPne107296_1637.

    Phylogenomic databases

    eggNOGi COG0768.
    HOGENOMi HOG000013470.
    KOi K00687.
    OrthoDBi EOG6N0HHV.

    Enzyme and pathway databases

    BioCyci SPNE171101:GJC8-1531-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P0A3M6.

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR005311. PBP_dimer.
    IPR001460. PCN-bd_Tpept.
    [Graphical view ]
    Pfami PF03717. PBP_dimer. 1 hit.
    PF00905. Transpeptidase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56519. SSF56519. 2 hits.
    SSF56601. SSF56601. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the penicillin-binding protein 2B gene of Streptococcus pneumoniae strain R6."
      Dowson C.G., Hutchison A., Spratt B.G.
      Nucleic Acids Res. 17:7518-7518(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-255 / R6.
    3. "Extensive re-modelling of the transpeptidase domain of penicillin-binding protein 2B of a penicillin-resistant South African isolate of Streptococcus pneumoniae."
      Dowson C.G., Hutchison A., Spratt B.G.
      Mol. Microbiol. 3:95-102(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 195-680.

    Entry informationi

    Entry nameiPBP2_STRR6
    AccessioniPrimary (citable) accession number: P0A3M6
    Secondary accession number(s): P10524
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3