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P0A3M6

- PBP2_STRR6

UniProt

P0A3M6 - PBP2_STRR6

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Protein

Penicillin-binding protein 2B

Gene

penA

Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. penicillin binding Source: InterPro

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciSPNE171101:GJC8-1531-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Penicillin-binding protein 2B
Gene namesi
Name:penA
Synonyms:pbp2b
Ordered Locus Names:spr1517
OrganismiStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Taxonomic identifieri171101 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000586: Chromosome

Subcellular locationi

Cell membrane By similarity; Single-pass membrane protein By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 680680Penicillin-binding protein 2BPRO_0000195456Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi171101.spr1517.

Structurei

Secondary structure

1
680
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi53 – 586
Beta strandi72 – 8312
Helixi90 – 10112
Helixi113 – 1208
Helixi124 – 1318
Helixi150 – 16011
Helixi171 – 18212
Helixi200 – 2089
Helixi209 – 2113
Beta strandi216 – 22510
Helixi231 – 2344
Turni240 – 2423
Helixi246 – 25510
Beta strandi264 – 2663
Helixi267 – 2715
Helixi273 – 2764
Beta strandi277 – 2848
Beta strandi293 – 2953
Beta strandi307 – 3115
Helixi314 – 33320
Turni334 – 3396
Beta strandi342 – 3487
Turni350 – 3523
Beta strandi354 – 36310
Turni365 – 3673
Beta strandi370 – 3723
Helixi376 – 3794
Helixi385 – 3884
Helixi389 – 39810
Beta strandi407 – 4104
Turni424 – 4285
Beta strandi431 – 4355
Helixi436 – 4416
Helixi445 – 45612
Helixi468 – 4703
Helixi471 – 48414
Turni485 – 4884
Beta strandi494 – 4963
Helixi509 – 5157
Turni516 – 5183
Beta strandi519 – 5235
Helixi525 – 53612
Beta strandi539 – 5424
Beta strandi545 – 5539
Beta strandi557 – 5659
Beta strandi570 – 5734
Helixi578 – 59316
Helixi602 – 6054
Beta strandi613 – 6164
Beta strandi619 – 6213
Beta strandi629 – 6313
Beta strandi634 – 6385
Beta strandi640 – 6423
Beta strandi645 – 6506
Beta strandi653 – 6553
Helixi661 – 67414

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WADX-ray2.18A/B/C1-680[»]
2WAEX-ray2.26A1-680[»]
2WAFX-ray3.29A1-680[»]
ProteinModelPortaliP0A3M6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A3M6.

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the transpeptidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0768.
HOGENOMiHOG000013470.
KOiK00687.
OrthoDBiEOG6N0HHV.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF03717. PBP_dimer. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56519. SSF56519. 2 hits.
SSF56601. SSF56601. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A3M6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRKFNSHSIP IRLNLLFSIV ILLFMTIIGR LLYMQVLNKD FYEKKLASAS
60 70 80 90 100
QTKITSSSAR GEIYDASGKP LVENTLKQVV SFTRSNKMTA TDLKETAKKL
110 120 130 140 150
LTYVSISSPN LTERQLADYY LADPEIYKKI VEALPSEKRL DSDGNRLSES
160 170 180 190 200
ELYNNAVDSV QTSQLNYTED EKKEIYLFSQ LNAVGNFATG TIATDPLNDS
210 220 230 240 250
QVAVIASISK EMPGISISTS WDRKVLETSL SSIVGSVSSE KAGLPAEEAE
260 270 280 290 300
AYLKKGYSLN DRVGTSYLEK QYEETLQGKR SVKEIHLDKY GNMESVDTIE
310 320 330 340 350
EGSKGNNIKL TIDLAFQDSV DALLKSYFNS ELENGGAKYS EGVYAVALNP
360 370 380 390 400
KTGAVLSMSG IKHDLKTGEL TPDSLGTVTN VFVPGSVVKA ATISSGWENG
410 420 430 440 450
VLSGNQTLTD QSIVFQGSAP INSWYTQAYG SFPITAVQAL EYSSNTYMVQ
460 470 480 490 500
TALGLMGQTY QPNMFVGTSN LESAMEKLRS TFGEYGLGTA TGIDLPDEST
510 520 530 540 550
GFVPKEYSFA NYITNAFGQF DNYTPMQLAQ YVATIANNGV RVAPRIVEGI
560 570 580 590 600
YGNNDKGGLG DLIQQLQPTE MNKVNISDSD MSILHQGFYQ VAHGTSGLTT
610 620 630 640 650
GRAFSNGALV SISGKTGTAE SYVADGQQAT NTNAVAYAPS DNPQIAVAVV
660 670 680
FPHNTNLTNG VGPSIARDII NLYQKYHPMN
Length:680
Mass (Da):73,873
Last modified:March 15, 2005 - v1
Checksum:i56BF2C1AA9B54C3B
GO

Sequence cautioni

The sequence AAL00321.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371L → F in CAA34154. (PubMed:2798106)Curated
Sequence conflicti115 – 1173QLA → AG in CAA34154. (PubMed:2798106)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X16022 Genomic DNA. Translation: CAA34154.1.
AE007317 Genomic DNA. Translation: AAL00321.1. Different initiation.
X13137 Genomic DNA. Translation: CAA31527.1.
PIRiD98061.
S06000.
RefSeqiNP_359110.1. NC_003098.1.

Genome annotation databases

EnsemblBacteriaiAAL00321; AAL00321; spr1517.
GeneIDi933948.
KEGGispr:spr1517.
PATRICi19703047. VBIStrPne107296_1637.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X16022 Genomic DNA. Translation: CAA34154.1 .
AE007317 Genomic DNA. Translation: AAL00321.1 . Different initiation.
X13137 Genomic DNA. Translation: CAA31527.1 .
PIRi D98061.
S06000.
RefSeqi NP_359110.1. NC_003098.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2WAD X-ray 2.18 A/B/C 1-680 [» ]
2WAE X-ray 2.26 A 1-680 [» ]
2WAF X-ray 3.29 A 1-680 [» ]
ProteinModelPortali P0A3M6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 171101.spr1517.

Chemistry

DrugBanki DB00415. Ampicillin.
DB08795. Azidocillin.
DB01140. Cefadroxil.
DB00456. Cefalotin.
DB01066. Cefditoren.
DB00493. Cefotaxime.
DB01331. Cefoxitin.
DB01212. Ceftriaxone.
DB00567. Cephalexin.
DB00485. Dicloxacillin.
DB00739. Hetacillin.
DB01603. Meticillin.
DB00607. Nafcillin.
DB00713. Oxacillin.
DB00319. Piperacillin.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL00321 ; AAL00321 ; spr1517 .
GeneIDi 933948.
KEGGi spr:spr1517.
PATRICi 19703047. VBIStrPne107296_1637.

Phylogenomic databases

eggNOGi COG0768.
HOGENOMi HOG000013470.
KOi K00687.
OrthoDBi EOG6N0HHV.

Enzyme and pathway databases

BioCyci SPNE171101:GJC8-1531-MONOMER.

Miscellaneous databases

EvolutionaryTracei P0A3M6.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
[Graphical view ]
Pfami PF03717. PBP_dimer. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view ]
SUPFAMi SSF56519. SSF56519. 2 hits.
SSF56601. SSF56601. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the penicillin-binding protein 2B gene of Streptococcus pneumoniae strain R6."
    Dowson C.G., Hutchison A., Spratt B.G.
    Nucleic Acids Res. 17:7518-7518(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-255 / R6.
  3. "Extensive re-modelling of the transpeptidase domain of penicillin-binding protein 2B of a penicillin-resistant South African isolate of Streptococcus pneumoniae."
    Dowson C.G., Hutchison A., Spratt B.G.
    Mol. Microbiol. 3:95-102(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 195-680.

Entry informationi

Entry nameiPBP2_STRR6
AccessioniPrimary (citable) accession number: P0A3M6
Secondary accession number(s): P10524
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3