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P0A3M5 (PBP2_STRPN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Penicillin-binding protein 2B
Gene names
Name:penA
Synonyms:pbp2b
Ordered Locus Names:SP_1673
OrganismStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) [Complete proteome] [HAMAP]
Taxonomic identifier170187 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length680 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Subcellular location

Cell membrane; Single-pass membrane protein By similarity.

Sequence similarities

Belongs to the transpeptidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 680680Penicillin-binding protein 2B
PRO_0000195455

Regions

Transmembrane9 – 2921Helical; Potential

Natural variations

Natural variant3331E → G in strain: 64147.
Natural variant426 – 4327TQAYGSF → PAFSRPM in strain: 64147.
Natural variant4461T → A in strain: 64147.
Natural variant4761E → G in strain: 64147.
Natural variant4891T → S in strain: 64147.
Natural variant5121Y → F in strain: 64147.
Natural variant5381N → D in strain: 64147.
Natural variant5971G → E in strain: 64147.
Natural variant674 – 6763QKY → NQH in strain: 64147.

Sequences

Sequence LengthMass (Da)Tools
P0A3M5 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: 56BF2C1AA9B54C3B

FASTA68073,873
        10         20         30         40         50         60 
MRKFNSHSIP IRLNLLFSIV ILLFMTIIGR LLYMQVLNKD FYEKKLASAS QTKITSSSAR 

        70         80         90        100        110        120 
GEIYDASGKP LVENTLKQVV SFTRSNKMTA TDLKETAKKL LTYVSISSPN LTERQLADYY 

       130        140        150        160        170        180 
LADPEIYKKI VEALPSEKRL DSDGNRLSES ELYNNAVDSV QTSQLNYTED EKKEIYLFSQ 

       190        200        210        220        230        240 
LNAVGNFATG TIATDPLNDS QVAVIASISK EMPGISISTS WDRKVLETSL SSIVGSVSSE 

       250        260        270        280        290        300 
KAGLPAEEAE AYLKKGYSLN DRVGTSYLEK QYEETLQGKR SVKEIHLDKY GNMESVDTIE 

       310        320        330        340        350        360 
EGSKGNNIKL TIDLAFQDSV DALLKSYFNS ELENGGAKYS EGVYAVALNP KTGAVLSMSG 

       370        380        390        400        410        420 
IKHDLKTGEL TPDSLGTVTN VFVPGSVVKA ATISSGWENG VLSGNQTLTD QSIVFQGSAP 

       430        440        450        460        470        480 
INSWYTQAYG SFPITAVQAL EYSSNTYMVQ TALGLMGQTY QPNMFVGTSN LESAMEKLRS 

       490        500        510        520        530        540 
TFGEYGLGTA TGIDLPDEST GFVPKEYSFA NYITNAFGQF DNYTPMQLAQ YVATIANNGV 

       550        560        570        580        590        600 
RVAPRIVEGI YGNNDKGGLG DLIQQLQPTE MNKVNISDSD MSILHQGFYQ VAHGTSGLTT 

       610        620        630        640        650        660 
GRAFSNGALV SISGKTGTAE SYVADGQQAT NTNAVAYAPS DNPQIAVAVV FPHNTNLTNG 

       670        680 
VGPSIARDII NLYQKYHPMN 

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of a virulent isolate of Streptococcus pneumoniae."
Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D., Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J., Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D., Umayam L.A., White O., Salzberg S.L. expand/collapse author list , Lewis M.R., Radune D., Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L., McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K., Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A., Morrison D.A., Hollingshead S.K., Fraser C.M.
Science 293:498-506(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-334 / TIGR4.
[2]"Extensive re-modelling of the transpeptidase domain of penicillin-binding protein 2B of a penicillin-resistant South African isolate of Streptococcus pneumoniae."
Dowson C.G., Hutchison A., Spratt B.G.
Mol. Microbiol. 3:95-102(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 195-680.
Strain: 64147.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE005672 Genomic DNA. Translation: AAK75752.1.
X13136 Genomic DNA. Translation: CAA31526.1.
PIRB35965.
G95194.
RefSeqNP_346112.1. NC_003028.3.

3D structure databases

ProteinModelPortalP0A3M5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING170187.SP_1673.

Chemistry

ChEMBLCHEMBL1255133.
DrugBankDB01163. Amdinocillin.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK75752; AAK75752; SP_1673.
GeneID931164.
KEGGspn:SP_1673.
PATRIC19707781. VBIStrPne105772_1733.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0768.
HOGENOMHOG000013470.
KOK00687.
OMAWKEFGDI.
OrthoDBEOG6N0HHV.
ProtClustDBCLSK873017.

Enzyme and pathway databases

BioCycSPNE170187:GHGN-1680-MONOMER.

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR012338. Beta-lactam/transpept-like.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamPF03717. PBP_dimer. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMSSF56519. SSF56519. 2 hits.
SSF56601. SSF56601. 1 hit.
ProtoNetSearch...

Entry information

Entry namePBP2_STRPN
AccessionPrimary (citable) accession number: P0A3M5
Secondary accession number(s): P10524
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: February 19, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families