Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P0A3M5

- PBP2_STRPN

UniProt

P0A3M5 - PBP2_STRPN

Protein

Penicillin-binding protein 2B

Gene

penA

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. penicillin binding Source: InterPro

    GO - Biological processi

    1. peptidoglycan biosynthetic process Source: UniProtKB-KW
    2. regulation of cell shape Source: UniProtKB-KW
    3. response to antibiotic Source: UniProtKB-KW

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciSPNE170187:GHGN-1680-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Penicillin-binding protein 2B
    Gene namesi
    Name:penA
    Synonyms:pbp2b
    Ordered Locus Names:SP_1673
    OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
    Taxonomic identifieri170187 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000585: Chromosome

    Subcellular locationi

    Cell membrane By similarity; Single-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 680680Penicillin-binding protein 2BPRO_0000195455Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi170187.SP_1673.

    Structurei

    3D structure databases

    ProteinModelPortaliP0A3M5.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 2921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the transpeptidase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0768.
    HOGENOMiHOG000013470.
    KOiK00687.
    OMAiWKEFGDI.
    OrthoDBiEOG6N0HHV.

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR005311. PBP_dimer.
    IPR001460. PCN-bd_Tpept.
    [Graphical view]
    PfamiPF03717. PBP_dimer. 1 hit.
    PF00905. Transpeptidase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56519. SSF56519. 2 hits.
    SSF56601. SSF56601. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0A3M5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRKFNSHSIP IRLNLLFSIV ILLFMTIIGR LLYMQVLNKD FYEKKLASAS    50
    QTKITSSSAR GEIYDASGKP LVENTLKQVV SFTRSNKMTA TDLKETAKKL 100
    LTYVSISSPN LTERQLADYY LADPEIYKKI VEALPSEKRL DSDGNRLSES 150
    ELYNNAVDSV QTSQLNYTED EKKEIYLFSQ LNAVGNFATG TIATDPLNDS 200
    QVAVIASISK EMPGISISTS WDRKVLETSL SSIVGSVSSE KAGLPAEEAE 250
    AYLKKGYSLN DRVGTSYLEK QYEETLQGKR SVKEIHLDKY GNMESVDTIE 300
    EGSKGNNIKL TIDLAFQDSV DALLKSYFNS ELENGGAKYS EGVYAVALNP 350
    KTGAVLSMSG IKHDLKTGEL TPDSLGTVTN VFVPGSVVKA ATISSGWENG 400
    VLSGNQTLTD QSIVFQGSAP INSWYTQAYG SFPITAVQAL EYSSNTYMVQ 450
    TALGLMGQTY QPNMFVGTSN LESAMEKLRS TFGEYGLGTA TGIDLPDEST 500
    GFVPKEYSFA NYITNAFGQF DNYTPMQLAQ YVATIANNGV RVAPRIVEGI 550
    YGNNDKGGLG DLIQQLQPTE MNKVNISDSD MSILHQGFYQ VAHGTSGLTT 600
    GRAFSNGALV SISGKTGTAE SYVADGQQAT NTNAVAYAPS DNPQIAVAVV 650
    FPHNTNLTNG VGPSIARDII NLYQKYHPMN 680
    Length:680
    Mass (Da):73,873
    Last modified:March 15, 2005 - v1
    Checksum:i56BF2C1AA9B54C3B
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti333 – 3331E → G in strain: 64147.
    Natural varianti426 – 4327TQAYGSF → PAFSRPM in strain: 64147.
    Natural varianti446 – 4461T → A in strain: 64147.
    Natural varianti476 – 4761E → G in strain: 64147.
    Natural varianti489 – 4891T → S in strain: 64147.
    Natural varianti512 – 5121Y → F in strain: 64147.
    Natural varianti538 – 5381N → D in strain: 64147.
    Natural varianti597 – 5971G → E in strain: 64147.
    Natural varianti674 – 6763QKY → NQH in strain: 64147.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005672 Genomic DNA. Translation: AAK75752.1.
    X13136 Genomic DNA. Translation: CAA31526.1.
    PIRiB35965.
    G95194.
    RefSeqiNP_346112.1. NC_003028.3.

    Genome annotation databases

    EnsemblBacteriaiAAK75752; AAK75752; SP_1673.
    GeneIDi931164.
    KEGGispn:SP_1673.
    PATRICi19707781. VBIStrPne105772_1733.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005672 Genomic DNA. Translation: AAK75752.1 .
    X13136 Genomic DNA. Translation: CAA31526.1 .
    PIRi B35965.
    G95194.
    RefSeqi NP_346112.1. NC_003028.3.

    3D structure databases

    ProteinModelPortali P0A3M5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 170187.SP_1673.

    Chemistry

    ChEMBLi CHEMBL1255133.
    DrugBanki DB01163. Amdinocillin.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK75752 ; AAK75752 ; SP_1673 .
    GeneIDi 931164.
    KEGGi spn:SP_1673.
    PATRICi 19707781. VBIStrPne105772_1733.

    Phylogenomic databases

    eggNOGi COG0768.
    HOGENOMi HOG000013470.
    KOi K00687.
    OMAi WKEFGDI.
    OrthoDBi EOG6N0HHV.

    Enzyme and pathway databases

    BioCyci SPNE170187:GHGN-1680-MONOMER.

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR005311. PBP_dimer.
    IPR001460. PCN-bd_Tpept.
    [Graphical view ]
    Pfami PF03717. PBP_dimer. 1 hit.
    PF00905. Transpeptidase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56519. SSF56519. 2 hits.
    SSF56601. SSF56601. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-334 / TIGR4.
    2. "Extensive re-modelling of the transpeptidase domain of penicillin-binding protein 2B of a penicillin-resistant South African isolate of Streptococcus pneumoniae."
      Dowson C.G., Hutchison A., Spratt B.G.
      Mol. Microbiol. 3:95-102(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 195-680.
      Strain: 64147.

    Entry informationi

    Entry nameiPBP2_STRPN
    AccessioniPrimary (citable) accession number: P0A3M5
    Secondary accession number(s): P10524
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3