Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P0A3M5

- PBP2_STRPN

UniProt

P0A3M5 - PBP2_STRPN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Penicillin-binding protein 2B

Gene

penA

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. penicillin binding Source: InterPro

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciSPNE170187:GHGN-1680-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Penicillin-binding protein 2B
Gene namesi
Name:penA
Synonyms:pbp2b
Ordered Locus Names:SP_1673
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000585: Chromosome

Subcellular locationi

Cell membrane By similarity; Single-pass membrane protein By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 680680Penicillin-binding protein 2BPRO_0000195455Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi170187.SP_1673.

Structurei

3D structure databases

ProteinModelPortaliP0A3M5.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the transpeptidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0768.
HOGENOMiHOG000013470.
KOiK00687.
OMAiWKEFGDI.
OrthoDBiEOG6N0HHV.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF03717. PBP_dimer. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56519. SSF56519. 2 hits.
SSF56601. SSF56601. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A3M5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRKFNSHSIP IRLNLLFSIV ILLFMTIIGR LLYMQVLNKD FYEKKLASAS
60 70 80 90 100
QTKITSSSAR GEIYDASGKP LVENTLKQVV SFTRSNKMTA TDLKETAKKL
110 120 130 140 150
LTYVSISSPN LTERQLADYY LADPEIYKKI VEALPSEKRL DSDGNRLSES
160 170 180 190 200
ELYNNAVDSV QTSQLNYTED EKKEIYLFSQ LNAVGNFATG TIATDPLNDS
210 220 230 240 250
QVAVIASISK EMPGISISTS WDRKVLETSL SSIVGSVSSE KAGLPAEEAE
260 270 280 290 300
AYLKKGYSLN DRVGTSYLEK QYEETLQGKR SVKEIHLDKY GNMESVDTIE
310 320 330 340 350
EGSKGNNIKL TIDLAFQDSV DALLKSYFNS ELENGGAKYS EGVYAVALNP
360 370 380 390 400
KTGAVLSMSG IKHDLKTGEL TPDSLGTVTN VFVPGSVVKA ATISSGWENG
410 420 430 440 450
VLSGNQTLTD QSIVFQGSAP INSWYTQAYG SFPITAVQAL EYSSNTYMVQ
460 470 480 490 500
TALGLMGQTY QPNMFVGTSN LESAMEKLRS TFGEYGLGTA TGIDLPDEST
510 520 530 540 550
GFVPKEYSFA NYITNAFGQF DNYTPMQLAQ YVATIANNGV RVAPRIVEGI
560 570 580 590 600
YGNNDKGGLG DLIQQLQPTE MNKVNISDSD MSILHQGFYQ VAHGTSGLTT
610 620 630 640 650
GRAFSNGALV SISGKTGTAE SYVADGQQAT NTNAVAYAPS DNPQIAVAVV
660 670 680
FPHNTNLTNG VGPSIARDII NLYQKYHPMN
Length:680
Mass (Da):73,873
Last modified:March 15, 2005 - v1
Checksum:i56BF2C1AA9B54C3B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti333 – 3331E → G in strain: 64147.
Natural varianti426 – 4327TQAYGSF → PAFSRPM in strain: 64147.
Natural varianti446 – 4461T → A in strain: 64147.
Natural varianti476 – 4761E → G in strain: 64147.
Natural varianti489 – 4891T → S in strain: 64147.
Natural varianti512 – 5121Y → F in strain: 64147.
Natural varianti538 – 5381N → D in strain: 64147.
Natural varianti597 – 5971G → E in strain: 64147.
Natural varianti674 – 6763QKY → NQH in strain: 64147.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005672 Genomic DNA. Translation: AAK75752.1.
X13136 Genomic DNA. Translation: CAA31526.1.
PIRiB35965.
G95194.
RefSeqiNP_346112.1. NC_003028.3.

Genome annotation databases

EnsemblBacteriaiAAK75752; AAK75752; SP_1673.
GeneIDi931164.
KEGGispn:SP_1673.
PATRICi19707781. VBIStrPne105772_1733.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005672 Genomic DNA. Translation: AAK75752.1 .
X13136 Genomic DNA. Translation: CAA31526.1 .
PIRi B35965.
G95194.
RefSeqi NP_346112.1. NC_003028.3.

3D structure databases

ProteinModelPortali P0A3M5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 170187.SP_1673.

Chemistry

ChEMBLi CHEMBL1255133.
DrugBanki DB01150. Cefprozil.
DB01147. Cloxacillin.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK75752 ; AAK75752 ; SP_1673 .
GeneIDi 931164.
KEGGi spn:SP_1673.
PATRICi 19707781. VBIStrPne105772_1733.

Phylogenomic databases

eggNOGi COG0768.
HOGENOMi HOG000013470.
KOi K00687.
OMAi WKEFGDI.
OrthoDBi EOG6N0HHV.

Enzyme and pathway databases

BioCyci SPNE170187:GHGN-1680-MONOMER.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
[Graphical view ]
Pfami PF03717. PBP_dimer. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view ]
SUPFAMi SSF56519. SSF56519. 2 hits.
SSF56601. SSF56601. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-334 / TIGR4.
  2. "Extensive re-modelling of the transpeptidase domain of penicillin-binding protein 2B of a penicillin-resistant South African isolate of Streptococcus pneumoniae."
    Dowson C.G., Hutchison A., Spratt B.G.
    Mol. Microbiol. 3:95-102(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 195-680.
    Strain: 64147.

Entry informationi

Entry nameiPBP2_STRPN
AccessioniPrimary (citable) accession number: P0A3M5
Secondary accession number(s): P10524
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3