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P0A3M5

- PBP2_STRPN

UniProt

P0A3M5 - PBP2_STRPN

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Protein
Penicillin-binding protein 2B
Gene
penA, pbp2b, SP_1673
Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. penicillin binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. peptidoglycan biosynthetic process Source: UniProtKB-KW
  2. regulation of cell shape Source: UniProtKB-KW
  3. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciSPNE170187:GHGN-1680-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Penicillin-binding protein 2B
Gene namesi
Name:penA
Synonyms:pbp2b
Ordered Locus Names:SP_1673
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000585: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 680680Penicillin-binding protein 2B
PRO_0000195455Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi170187.SP_1673.

Structurei

3D structure databases

ProteinModelPortaliP0A3M5.

Family & Domainsi

Sequence similaritiesi

Belongs to the transpeptidase family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0768.
HOGENOMiHOG000013470.
KOiK00687.
OMAiWKEFGDI.
OrthoDBiEOG6N0HHV.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF03717. PBP_dimer. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56519. SSF56519. 2 hits.
SSF56601. SSF56601. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A3M5-1 [UniParc]FASTAAdd to Basket

« Hide

MRKFNSHSIP IRLNLLFSIV ILLFMTIIGR LLYMQVLNKD FYEKKLASAS    50
QTKITSSSAR GEIYDASGKP LVENTLKQVV SFTRSNKMTA TDLKETAKKL 100
LTYVSISSPN LTERQLADYY LADPEIYKKI VEALPSEKRL DSDGNRLSES 150
ELYNNAVDSV QTSQLNYTED EKKEIYLFSQ LNAVGNFATG TIATDPLNDS 200
QVAVIASISK EMPGISISTS WDRKVLETSL SSIVGSVSSE KAGLPAEEAE 250
AYLKKGYSLN DRVGTSYLEK QYEETLQGKR SVKEIHLDKY GNMESVDTIE 300
EGSKGNNIKL TIDLAFQDSV DALLKSYFNS ELENGGAKYS EGVYAVALNP 350
KTGAVLSMSG IKHDLKTGEL TPDSLGTVTN VFVPGSVVKA ATISSGWENG 400
VLSGNQTLTD QSIVFQGSAP INSWYTQAYG SFPITAVQAL EYSSNTYMVQ 450
TALGLMGQTY QPNMFVGTSN LESAMEKLRS TFGEYGLGTA TGIDLPDEST 500
GFVPKEYSFA NYITNAFGQF DNYTPMQLAQ YVATIANNGV RVAPRIVEGI 550
YGNNDKGGLG DLIQQLQPTE MNKVNISDSD MSILHQGFYQ VAHGTSGLTT 600
GRAFSNGALV SISGKTGTAE SYVADGQQAT NTNAVAYAPS DNPQIAVAVV 650
FPHNTNLTNG VGPSIARDII NLYQKYHPMN 680
Length:680
Mass (Da):73,873
Last modified:March 15, 2005 - v1
Checksum:i56BF2C1AA9B54C3B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti333 – 3331E → G in strain: 64147.
Natural varianti426 – 4327TQAYGSF → PAFSRPM in strain: 64147.
Natural varianti446 – 4461T → A in strain: 64147.
Natural varianti476 – 4761E → G in strain: 64147.
Natural varianti489 – 4891T → S in strain: 64147.
Natural varianti512 – 5121Y → F in strain: 64147.
Natural varianti538 – 5381N → D in strain: 64147.
Natural varianti597 – 5971G → E in strain: 64147.
Natural varianti674 – 6763QKY → NQH in strain: 64147.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005672 Genomic DNA. Translation: AAK75752.1.
X13136 Genomic DNA. Translation: CAA31526.1.
PIRiB35965.
G95194.
RefSeqiNP_346112.1. NC_003028.3.

Genome annotation databases

EnsemblBacteriaiAAK75752; AAK75752; SP_1673.
GeneIDi931164.
KEGGispn:SP_1673.
PATRICi19707781. VBIStrPne105772_1733.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005672 Genomic DNA. Translation: AAK75752.1 .
X13136 Genomic DNA. Translation: CAA31526.1 .
PIRi B35965.
G95194.
RefSeqi NP_346112.1. NC_003028.3.

3D structure databases

ProteinModelPortali P0A3M5.
ModBasei Search...

Protein-protein interaction databases

STRINGi 170187.SP_1673.

Chemistry

ChEMBLi CHEMBL1255133.
DrugBanki DB01163. Amdinocillin.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK75752 ; AAK75752 ; SP_1673 .
GeneIDi 931164.
KEGGi spn:SP_1673.
PATRICi 19707781. VBIStrPne105772_1733.

Phylogenomic databases

eggNOGi COG0768.
HOGENOMi HOG000013470.
KOi K00687.
OMAi WKEFGDI.
OrthoDBi EOG6N0HHV.

Enzyme and pathway databases

BioCyci SPNE170187:GHGN-1680-MONOMER.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
[Graphical view ]
Pfami PF03717. PBP_dimer. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view ]
SUPFAMi SSF56519. SSF56519. 2 hits.
SSF56601. SSF56601. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-334 / TIGR4.
  2. "Extensive re-modelling of the transpeptidase domain of penicillin-binding protein 2B of a penicillin-resistant South African isolate of Streptococcus pneumoniae."
    Dowson C.G., Hutchison A., Spratt B.G.
    Mol. Microbiol. 3:95-102(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 195-680.
    Strain: 64147.

Entry informationi

Entry nameiPBP2_STRPN
AccessioniPrimary (citable) accession number: P0A3M5
Secondary accession number(s): P10524
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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