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P0A3M4

- BLO9_ENTAE

UniProt

P0A3M4 - BLO9_ENTAE

Protein

Beta-lactamase OXA-9

Gene

bla

Organism
Enterobacter aerogenes (Aerobacter aerogenes)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 2 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Oxacillin-hydrolyzing beta-lactamase. Confers resistance to beta-lactam antibiotics but at a significantly lower level than the TEM bla gene product.

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei58 – 581Acyl-ester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC
    2. penicillin binding Source: InterPro

    GO - Biological processi

    1. antibiotic catabolic process Source: InterPro
    2. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Enzyme and pathway databases

    SABIO-RKP0A3M4.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-lactamase OXA-9 (EC:3.5.2.6)
    Alternative name(s):
    Oxacillinase
    Penicillinase
    Gene namesi
    Name:bla
    Synonyms:oxa9
    Encoded oniPlasmid pIP8330 Publication
    OrganismiEnterobacter aerogenes (Aerobacter aerogenes)
    Taxonomic identifieri548 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacter

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 274250Beta-lactamase OXA-9PRO_0000017035Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei61 – 611N6-carboxylysineBy similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP0A3M4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni206 – 2083Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the class-D beta-lactamase family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR002137. Beta-lactam_class-D_AS.
    IPR001460. PCN-bd_Tpept.
    [Graphical view]
    PfamiPF00905. Transpeptidase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56601. SSF56601. 1 hit.
    PROSITEiPS00337. BETA_LACTAMASE_D. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0A3M4-1 [UniParc]FASTAAdd to Basket

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    MKKILLLHML VFVSATLPIS SVASDEVETL KCTIIADAIT GNTLYETGEC    50
    ARRVSPCSSF KLPLAIMGFD SGILQSPKSP TWELKPEYNP SPRDRTYKQV 100
    YPALWQSDSV VWFSQQLTSR LGVDRFTEYV KKFEYGNQDV SGDSGKHNGL 150
    TQSWLMSSLT ISPKEQIQFL LRFVAHKLPV SEAAYDMAYA TIPQYQAAEG 200
    WAVHGKSGSG WLRDNNGKIN ESRPQGWFVG WAEKNGRQVV FARLEIGKEK 250
    SDIPGGSKAR EDILVELPVL MGNK 274
    Length:274
    Mass (Da):30,568
    Last modified:January 15, 2008 - v2
    Checksum:iCA96C211CEFF5F2D
    GO

    Sequence cautioni

    The sequence AAD22145.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF034958 Genomic DNA. Translation: AAD22145.1. Different initiation.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF034958 Genomic DNA. Translation: AAD22145.1 . Different initiation.

    3D structure databases

    ProteinModelPortali P0A3M4.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL1744486.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    SABIO-RK P0A3M4.

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR002137. Beta-lactam_class-D_AS.
    IPR001460. PCN-bd_Tpept.
    [Graphical view ]
    Pfami PF00905. Transpeptidase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56601. SSF56601. 1 hit.
    PROSITEi PS00337. BETA_LACTAMASE_D. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of In40 of Enterobacter aerogenes BM2688, a class 1 integron with two new gene cassettes, cmlA2 and qacF."
      Ploy M.-C., Courvalin P., Lambert T.
      Antimicrob. Agents Chemother. 42:2557-2563(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BM2688-1.
      Transposon: In40.

    Entry informationi

    Entry nameiBLO9_ENTAE
    AccessioniPrimary (citable) accession number: P0A3M4
    Secondary accession number(s): P22070
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 36 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Plasmid, Transposable element

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3