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Protein

Beta-lactamase OXA-9

Gene

bla

Organism
Enterobacter aerogenes (Aerobacter aerogenes)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Oxacillin-hydrolyzing beta-lactamase. Confers resistance to beta-lactam antibiotics but at a significantly lower level than the TEM bla gene product.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei58 – 581Acyl-ester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Enzyme and pathway databases

SABIO-RKP0A3M4.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase OXA-9 (EC:3.5.2.6)
Alternative name(s):
Oxacillinase
Penicillinase
Gene namesi
Name:bla
Synonyms:oxa9
Encoded oniPlasmid pIP8330 Publication
OrganismiEnterobacter aerogenes (Aerobacter aerogenes)
Taxonomic identifieri548 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEnterobacter

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 274250Beta-lactamase OXA-9PRO_0000017035Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei61 – 611N6-carboxylysineBy similarity

Structurei

3D structure databases

ProteinModelPortaliP0A3M4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni206 – 2083Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the class-D beta-lactamase family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00337. BETA_LACTAMASE_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A3M4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKILLLHML VFVSATLPIS SVASDEVETL KCTIIADAIT GNTLYETGEC
60 70 80 90 100
ARRVSPCSSF KLPLAIMGFD SGILQSPKSP TWELKPEYNP SPRDRTYKQV
110 120 130 140 150
YPALWQSDSV VWFSQQLTSR LGVDRFTEYV KKFEYGNQDV SGDSGKHNGL
160 170 180 190 200
TQSWLMSSLT ISPKEQIQFL LRFVAHKLPV SEAAYDMAYA TIPQYQAAEG
210 220 230 240 250
WAVHGKSGSG WLRDNNGKIN ESRPQGWFVG WAEKNGRQVV FARLEIGKEK
260 270
SDIPGGSKAR EDILVELPVL MGNK
Length:274
Mass (Da):30,568
Last modified:January 15, 2008 - v2
Checksum:iCA96C211CEFF5F2D
GO

Sequence cautioni

The sequence AAD22145.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034958 Genomic DNA. Translation: AAD22145.1. Different initiation.
RefSeqiYP_009082213.1. NG_036654.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034958 Genomic DNA. Translation: AAD22145.1. Different initiation.
RefSeqiYP_009082213.1. NG_036654.1.

3D structure databases

ProteinModelPortaliP0A3M4.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

ChEMBLiCHEMBL1744486.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

SABIO-RKP0A3M4.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00337. BETA_LACTAMASE_D. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of In40 of Enterobacter aerogenes BM2688, a class 1 integron with two new gene cassettes, cmlA2 and qacF."
    Ploy M.-C., Courvalin P., Lambert T.
    Antimicrob. Agents Chemother. 42:2557-2563(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BM2688-1.
    Transposon: In40.

Entry informationi

Entry nameiBLO9_ENTAE
AccessioniPrimary (citable) accession number: P0A3M4
Secondary accession number(s): P22070
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: January 15, 2008
Last modified: January 7, 2015
This is version 37 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid, Transposable element

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.