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P0A3M3

- BLO9_KLEPN

UniProt

P0A3M3 - BLO9_KLEPN

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Protein

Beta-lactamase OXA-9

Gene
bla, oxa9
Organism
Klebsiella pneumoniae
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Oxacillin-hydrolyzing beta-lactamase. Confers resistance to beta-lactam antibiotics but at a significantly lower level than the TEM bla gene product.1 Publication

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei58 – 581Acyl-ester intermediate By similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC
  2. penicillin binding Source: InterPro

GO - Biological processi

  1. antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase OXA-9 (EC:3.5.2.6)
Alternative name(s):
Oxacillinase
Penicillinase
Gene namesi
Name:bla
Synonyms:oxa9
Encoded oniPlasmid pJMCMW10 Publication
OrganismiKlebsiella pneumoniae
Taxonomic identifieri573 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed predictionAdd
BLAST
Chaini25 – 274250Beta-lactamase OXA-9PRO_0000017036Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei61 – 611N6-carboxylysine By similarity

Structurei

3D structure databases

ProteinModelPortaliP0A3M3.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni206 – 2083Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
PROSITEiPS00337. BETA_LACTAMASE_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A3M3-1 [UniParc]FASTAAdd to Basket

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MKKILLLHML VFVSATLPIS SVASDEVETL KCTIIADAIT GNTLYETGEC    50
ARRVSPCSSF KLPLAIMGFD SGILQSPKSP TWELKPEYNP SPRDRTYKQV 100
YPALWQSDSV VWFSQQLTSR LGVDRFTEYV KKFEYGNQDV SGDSGKHNGL 150
TQSWLMSSLT ISPKEQIQFL LRFVAHKLPV SEAAYDMAYA TIPQYQAAEG 200
WAVHGKSGSG WLRDNNGKIN ESRPQGWFVG WAEKNGRQVV FARLEIGKEK 250
SDIPGGSKAR EDILVELPVL MGNK 274
Length:274
Mass (Da):30,568
Last modified:May 30, 2006 - v2
Checksum:iCA96C211CEFF5F2D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M55547 Genomic DNA. Translation: AAA98406.2.
AF479774 Genomic DNA. Translation: AAL93143.2.
PIRiD37392.
RefSeqiNP_608309.2. NC_003486.1.
YP_007878590.1. NC_021079.1.
YP_008603397.1. NC_022520.1.

Genome annotation databases

GeneIDi1238791.
15334410.
17111304.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M55547 Genomic DNA. Translation: AAA98406.2 .
AF479774 Genomic DNA. Translation: AAL93143.2 .
PIRi D37392.
RefSeqi NP_608309.2. NC_003486.1.
YP_007878590.1. NC_021079.1.
YP_008603397.1. NC_022520.1.

3D structure databases

ProteinModelPortali P0A3M3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1238791.
15334410.
17111304.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR002137. Beta-lactam_class-D_AS.
IPR001460. PCN-bd_Tpept.
[Graphical view ]
Pfami PF00905. Transpeptidase. 1 hit.
[Graphical view ]
SUPFAMi SSF56601. SSF56601. 1 hit.
PROSITEi PS00337. BETA_LACTAMASE_D. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequencing and expression of aadA, bla, and tnpR from the multiresistance transposon Tn1331."
    Tolmasky M.E.
    Plasmid 24:218-226(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Transposon: Tn1331.
  2. Tolmasky M.E.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO N-TERMINUS.
  3. "Complete nucleotide sequence of Klebsiella pneumoniae multiresistance plasmid pJHCMW1."
    Sarno R., McGillivary G., Sherratt D.J., Actis L.A., Tolmasky M.E.
    Antimicrob. Agents Chemother. 46:3422-3427(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Genetic organization of antibiotic resistance genes (aac(6')-Ib, aadA, and oxa9) in the multiresistance transposon Tn1331."
    Tolmasky M.E., Crosa J.H.
    Plasmid 29:31-40(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiBLO9_KLEPN
AccessioniPrimary (citable) accession number: P0A3M3
Secondary accession number(s): P22070, Q7WWR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: May 30, 2006
Last modified: May 14, 2014
This is version 41 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid, Transposable element

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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