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P0A3M3

- BLO9_KLEPN

UniProt

P0A3M3 - BLO9_KLEPN

Protein

Beta-lactamase OXA-9

Gene

bla

Organism
Klebsiella pneumoniae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 2 (30 May 2006)
      Previous versions | rss
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    Functioni

    Oxacillin-hydrolyzing beta-lactamase. Confers resistance to beta-lactam antibiotics but at a significantly lower level than the TEM bla gene product.1 Publication

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei58 – 581Acyl-ester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC
    2. penicillin binding Source: InterPro

    GO - Biological processi

    1. antibiotic catabolic process Source: InterPro
    2. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-lactamase OXA-9 (EC:3.5.2.6)
    Alternative name(s):
    Oxacillinase
    Penicillinase
    Gene namesi
    Name:bla
    Synonyms:oxa9
    Encoded oniPlasmid pJMCMW10 Publication
    OrganismiKlebsiella pneumoniae
    Taxonomic identifieri573 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 274250Beta-lactamase OXA-9PRO_0000017036Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei61 – 611N6-carboxylysineBy similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP0A3M3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni206 – 2083Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the class-D beta-lactamase family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR002137. Beta-lactam_class-D_AS.
    IPR001460. PCN-bd_Tpept.
    [Graphical view]
    PfamiPF00905. Transpeptidase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56601. SSF56601. 1 hit.
    PROSITEiPS00337. BETA_LACTAMASE_D. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0A3M3-1 [UniParc]FASTAAdd to Basket

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    MKKILLLHML VFVSATLPIS SVASDEVETL KCTIIADAIT GNTLYETGEC    50
    ARRVSPCSSF KLPLAIMGFD SGILQSPKSP TWELKPEYNP SPRDRTYKQV 100
    YPALWQSDSV VWFSQQLTSR LGVDRFTEYV KKFEYGNQDV SGDSGKHNGL 150
    TQSWLMSSLT ISPKEQIQFL LRFVAHKLPV SEAAYDMAYA TIPQYQAAEG 200
    WAVHGKSGSG WLRDNNGKIN ESRPQGWFVG WAEKNGRQVV FARLEIGKEK 250
    SDIPGGSKAR EDILVELPVL MGNK 274
    Length:274
    Mass (Da):30,568
    Last modified:May 30, 2006 - v2
    Checksum:iCA96C211CEFF5F2D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M55547 Genomic DNA. Translation: AAA98406.2.
    AF479774 Genomic DNA. Translation: AAL93143.2.
    PIRiD37392.
    RefSeqiNP_608309.2. NC_003486.1.
    YP_007878590.1. NC_021079.1.
    YP_008603397.1. NC_022520.1.

    Genome annotation databases

    GeneIDi1238791.
    15334410.
    17111304.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M55547 Genomic DNA. Translation: AAA98406.2 .
    AF479774 Genomic DNA. Translation: AAL93143.2 .
    PIRi D37392.
    RefSeqi NP_608309.2. NC_003486.1.
    YP_007878590.1. NC_021079.1.
    YP_008603397.1. NC_022520.1.

    3D structure databases

    ProteinModelPortali P0A3M3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1238791.
    15334410.
    17111304.

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR002137. Beta-lactam_class-D_AS.
    IPR001460. PCN-bd_Tpept.
    [Graphical view ]
    Pfami PF00905. Transpeptidase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56601. SSF56601. 1 hit.
    PROSITEi PS00337. BETA_LACTAMASE_D. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequencing and expression of aadA, bla, and tnpR from the multiresistance transposon Tn1331."
      Tolmasky M.E.
      Plasmid 24:218-226(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Transposon: Tn1331.
    2. Tolmasky M.E.
      Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO N-TERMINUS.
    3. "Complete nucleotide sequence of Klebsiella pneumoniae multiresistance plasmid pJHCMW1."
      Sarno R., McGillivary G., Sherratt D.J., Actis L.A., Tolmasky M.E.
      Antimicrob. Agents Chemother. 46:3422-3427(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Genetic organization of antibiotic resistance genes (aac(6')-Ib, aadA, and oxa9) in the multiresistance transposon Tn1331."
      Tolmasky M.E., Crosa J.H.
      Plasmid 29:31-40(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiBLO9_KLEPN
    AccessioniPrimary (citable) accession number: P0A3M3
    Secondary accession number(s): P22070, Q7WWR7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: May 30, 2006
    Last modified: October 1, 2014
    This is version 42 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Plasmid, Transposable element

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3