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Protein

Thymidine kinase

Gene

tdk

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Phosphorylates both thymidine and deoxyuridine.By similarity

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Enzyme regulationi

Allosteric enzyme which is feedback inhibited by dTTP and activated by a number of dNDP and dNTP.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei88Proton acceptorUniRule annotation1
Metal bindingi145ZincUniRule annotation1
Metal bindingi147ZincUniRule annotation1
Metal bindingi182ZincUniRule annotation1
Metal bindingi185ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 16ATPUniRule annotation8
Nucleotide bindingi87 – 90ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Kinase, Transferase
Biological processDNA synthesis
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Z2015, ECs1740
OrganismiEscherichia coli O157:H7
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001749731 – 205Thymidine kinaseAdd BLAST205

Proteomic databases

PRIDEiP0A3L9

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi155864.Z2015

Structurei

3D structure databases

ProteinModelPortaliP0A3L9
SMRiP0A3L9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107104 Bacteria
COG1435 LUCA
HOGENOMiHOG000076391
KOiK00857
OMAiKEQFGWI

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
IPR020633 Thymidine_kinase_CS
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00603 TK_CELLULAR_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

P0A3L9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQLYFYYSA MNAGKSTALL QSSYNYQERG MRTVVYTAEI DDRFGAGKVS
60 70 80 90 100
SRIGLSSPAK LFNQNSSLFD EIRAEHEQQA IHCVLVDECQ FLTRQQVYEL
110 120 130 140 150
SEVVDQLDIP VLCYGLRTDF RGELFIGSQY LLAWSDKLVE LKTICFCGRK
160 170 180 190 200
ASMVLRLDQA GRPYNEGEQV VIGGNERYVS VCRKHYKEAL QVGSLTAIQE

RHRHD
Length:205
Mass (Da):23,399
Last modified:March 1, 2005 - v1
Checksum:i533166D9E91D0E16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008676 Genomic DNA Translation: BAA77748.1
AE005174 Genomic DNA Translation: AAG56095.1
BA000007 Genomic DNA Translation: BAB35163.1
PIRiC85704
D90846
RefSeqiNP_309767.1, NC_002695.1
WP_000068079.1, NZ_NOKN01000002.1

Genome annotation databases

EnsemblBacteriaiAAG56095; AAG56095; Z2015
BAB35163; BAB35163; BAB35163
GeneIDi913112
KEGGiece:Z2015
ecs:ECs1740
PATRICifig|386585.9.peg.1841

Similar proteinsi

Entry informationi

Entry nameiKITH_ECO57
AccessioniPrimary (citable) accession number: P0A3L9
Secondary accession number(s): Q9S5G7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: April 25, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health