Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Chaperone protein DnaK

Gene

dnaK

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Acts as a chaperone.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein DnaK
Alternative name(s):
HSP70
Heat shock 70 kDa protein
Heat shock protein 70
Gene namesi
Name:dnaK
Ordered Locus Names:LL0954
ORF Names:L178206
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
Proteomesi
  • UP000002196 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000784731 – 607Chaperone protein DnaKAdd BLAST607

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei173Phosphothreonine; by autocatalysisBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP0A3J0.
PRIDEiP0A3J0.

Expressioni

Inductioni

By stress conditions e.g. heat shock (By similarity).By similarity

Interactioni

Protein-protein interaction databases

STRINGi272623.L178206.

Structurei

3D structure databases

ProteinModelPortaliP0A3J0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiENOG4105CFG. Bacteria.
COG0443. LUCA.
HOGENOMiHOG000228136.
KOiK04043.
OMAiEKMAPPQ.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK. 1 hit.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A3J0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKIIGIDLG TTNSAVAVLE GTESKIIPNP EGNRTTPSVV AFKNGEIIVG
60 70 80 90 100
DAAKRQAVTN PETIISIKSK MGTSEKVSAN GKEYTPQEIS AMILQNLKAT
110 120 130 140 150
AEAYLGEKVE KAVITVPAYF NDAQRQATKD AGKIAGLEVE RIVNEPTAAA
160 170 180 190 200
LAYGLDKTDK DEKILVFDLG GGTFDVSILE LGDGVFDVLA TAGNNKLGGD
210 220 230 240 250
DFDQKIIDWM VAEFKKENGI DLAQDKMALQ RLKDAAEKAK KDLSGVTTTQ
260 270 280 290 300
ISLPFITAGA AGPLHLEMAL TRAKFDELTH DLVEATRQPV RQALSDAGLS
310 320 330 340 350
TSDIDEVLLV GGSTRIPAVV ELVRHETNKE PNKSVNPDEV VAMGAAIQGG
360 370 380 390 400
VITGDVKDVV LLDVTPLSLG IETMGGVFTK LIDRNTTIPT SKSQVFSTAA
410 420 430 440 450
DNQPAVDIHV LQGERPMAAD NKTLGRFQLT DIPAAPRGIP QIEVTFDIDK
460 470 480 490 500
NGIVSVKAKD LGTQKEQTIV IKSNSGLSDE EIDKMMKDAE ANADADAKRK
510 520 530 540 550
EEVDTRNEAD ALVFQTEKTL KDLEGKVEEA EVKKAEEAKE ELKKALEGED
560 570 580 590 600
IDDIKAKSEA LSEIAQNLAV KLYEQANAAQ GEAGQATDAQ EAPKDDNTFD

GDFEESK
Length:607
Mass (Da):64,987
Last modified:March 15, 2005 - v1
Checksum:i4CCF75695368093D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti103A → S in strain: LM0230. 1
Natural varianti223A → G in strain: LM0230. 1
Natural varianti537E → D in strain: LM0230. 1
Natural varianti584 – 585GQ → SE in strain: LM0230. 2
Natural varianti592A → G in strain: LM0230. 1
Natural varianti596D → A in strain: LM0230. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75428 Genomic DNA. Translation: CAA53179.1.
AE005176 Genomic DNA. Translation: AAK05052.1.
PIRiB86744.
S39342.
RefSeqiNP_267110.1. NC_002662.1.
WP_010905652.1. NC_002662.1.

Genome annotation databases

EnsemblBacteriaiAAK05052; AAK05052; L178206.
GeneIDi1114585.
KEGGilla:L178206.
PATRICi22294228. VBILacLac136773_1021.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75428 Genomic DNA. Translation: CAA53179.1.
AE005176 Genomic DNA. Translation: AAK05052.1.
PIRiB86744.
S39342.
RefSeqiNP_267110.1. NC_002662.1.
WP_010905652.1. NC_002662.1.

3D structure databases

ProteinModelPortaliP0A3J0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272623.L178206.

Proteomic databases

PaxDbiP0A3J0.
PRIDEiP0A3J0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK05052; AAK05052; L178206.
GeneIDi1114585.
KEGGilla:L178206.
PATRICi22294228. VBILacLac136773_1021.

Phylogenomic databases

eggNOGiENOG4105CFG. Bacteria.
COG0443. LUCA.
HOGENOMiHOG000228136.
KOiK04043.
OMAiEKMAPPQ.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK. 1 hit.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNAK_LACLA
AccessioniPrimary (citable) accession number: P0A3J0
Secondary accession number(s): P42368, Q9CGY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: November 2, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.