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Protein

Chaperone protein DnaK

Gene

dnaK

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Acts as a chaperone.By similarity

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • mannan binding Source: CAFA
  • unfolded protein binding Source: InterPro

GO - Biological processi

  • aggregation of unicellular organisms Source: CAFA
  • protein folding Source: InterPro

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLLAC272623:G1FZA-1016-MONOMER

Protein family/group databases

MoonProtiP0A3J0

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein DnaK
Alternative name(s):
HSP70
Heat shock 70 kDa protein
Heat shock protein 70
Gene namesi
Name:dnaK
Ordered Locus Names:LL0954
ORF Names:L178206
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
Proteomesi
  • UP000002196 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: CAFA

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000784731 – 607Chaperone protein DnaKAdd BLAST607

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei173Phosphothreonine; by autocatalysisBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP0A3J0
PRIDEiP0A3J0

Expressioni

Inductioni

By stress conditions e.g. heat shock (By similarity).By similarity

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi272623.L178206

Structurei

3D structure databases

ProteinModelPortaliP0A3J0
SMRiP0A3J0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiENOG4105CFG Bacteria
COG0443 LUCA
HOGENOMiHOG000228136
KOiK04043
OMAiISIKRHM

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
HAMAPiMF_00332 DnaK, 1 hit
InterProiView protein in InterPro
IPR012725 Chaperone_DnaK
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 2 hits
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100920 SSF100920, 1 hit
SSF100934 SSF100934, 1 hit
TIGRFAMsiTIGR02350 prok_dnaK, 1 hit
PROSITEiView protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

Sequencei

Sequence statusi: Complete.

P0A3J0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKIIGIDLG TTNSAVAVLE GTESKIIPNP EGNRTTPSVV AFKNGEIIVG
60 70 80 90 100
DAAKRQAVTN PETIISIKSK MGTSEKVSAN GKEYTPQEIS AMILQNLKAT
110 120 130 140 150
AEAYLGEKVE KAVITVPAYF NDAQRQATKD AGKIAGLEVE RIVNEPTAAA
160 170 180 190 200
LAYGLDKTDK DEKILVFDLG GGTFDVSILE LGDGVFDVLA TAGNNKLGGD
210 220 230 240 250
DFDQKIIDWM VAEFKKENGI DLAQDKMALQ RLKDAAEKAK KDLSGVTTTQ
260 270 280 290 300
ISLPFITAGA AGPLHLEMAL TRAKFDELTH DLVEATRQPV RQALSDAGLS
310 320 330 340 350
TSDIDEVLLV GGSTRIPAVV ELVRHETNKE PNKSVNPDEV VAMGAAIQGG
360 370 380 390 400
VITGDVKDVV LLDVTPLSLG IETMGGVFTK LIDRNTTIPT SKSQVFSTAA
410 420 430 440 450
DNQPAVDIHV LQGERPMAAD NKTLGRFQLT DIPAAPRGIP QIEVTFDIDK
460 470 480 490 500
NGIVSVKAKD LGTQKEQTIV IKSNSGLSDE EIDKMMKDAE ANADADAKRK
510 520 530 540 550
EEVDTRNEAD ALVFQTEKTL KDLEGKVEEA EVKKAEEAKE ELKKALEGED
560 570 580 590 600
IDDIKAKSEA LSEIAQNLAV KLYEQANAAQ GEAGQATDAQ EAPKDDNTFD

GDFEESK
Length:607
Mass (Da):64,987
Last modified:March 15, 2005 - v1
Checksum:i4CCF75695368093D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti103A → S in strain: LM0230. 1
Natural varianti223A → G in strain: LM0230. 1
Natural varianti537E → D in strain: LM0230. 1
Natural varianti584 – 585GQ → SE in strain: LM0230. 2
Natural varianti592A → G in strain: LM0230. 1
Natural varianti596D → A in strain: LM0230. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75428 Genomic DNA Translation: CAA53179.1
AE005176 Genomic DNA Translation: AAK05052.1
PIRiB86744
S39342
RefSeqiNP_267110.1, NC_002662.1
WP_010905652.1, NC_002662.1

Genome annotation databases

EnsemblBacteriaiAAK05052; AAK05052; L178206
GeneIDi1114585
KEGGilla:L178206
PATRICifig|272623.7.peg.1021

Similar proteinsi

Entry informationi

Entry nameiDNAK_LACLA
AccessioniPrimary (citable) accession number: P0A3J0
Secondary accession number(s): P42368, Q9CGY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: April 25, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health