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Protein

RNA-binding protein Hfq

Gene

hfq

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Stress response

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein HfqUniRule annotation
Gene namesi
Name:hfqUniRule annotation
Ordered Locus Names:BR1111, BS1330_I1107
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000007104 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7878RNA-binding protein HfqPRO_0000095630Add
BLAST

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP0A3G8.
SMRiP0A3G8. Positions 7-71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Hfq family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1923.
HOGENOMiHOG000004931.
KOiK03666.
OMAiQDPYLNV.
OrthoDBiEOG68SW3W.

Family and domain databases

HAMAPiMF_00436. Hfq.
InterProiIPR005001. Hfq.
IPR010920. LSM_dom.
IPR001163. Ribonucl_LSM.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
TIGRFAMsiTIGR02383. Hfq. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A3G8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAERSQNLQD LFLNSVRKQK ISLTIFLING VKLTGIVTSF DNFCVLLRRD
60 70
GHSQLVYKHA ISTIMPSQPV QMFEGEEA
Length:78
Mass (Da):8,854
Last modified:March 15, 2005 - v1
Checksum:i0D27DBD9CA161BD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA. Translation: AAN30031.1.
CP002997 Genomic DNA. Translation: AEM18449.1.
RefSeqiWP_002964239.1. NZ_KN046804.1.

Genome annotation databases

EnsemblBacteriaiAAN30031; AAN30031; BR1111.
AEM18449; AEM18449; BS1330_I1107.
GeneIDi5380709.
KEGGibms:BR1111.
bsi:BS1330_I1107.
PATRICi17790554. VBIBruSui107850_1131.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA. Translation: AAN30031.1.
CP002997 Genomic DNA. Translation: AEM18449.1.
RefSeqiWP_002964239.1. NZ_KN046804.1.

3D structure databases

ProteinModelPortaliP0A3G8.
SMRiP0A3G8. Positions 7-71.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN30031; AAN30031; BR1111.
AEM18449; AEM18449; BS1330_I1107.
GeneIDi5380709.
KEGGibms:BR1111.
bsi:BS1330_I1107.
PATRICi17790554. VBIBruSui107850_1131.

Phylogenomic databases

eggNOGiCOG1923.
HOGENOMiHOG000004931.
KOiK03666.
OMAiQDPYLNV.
OrthoDBiEOG68SW3W.

Miscellaneous databases

PROiP0A3G8.

Family and domain databases

HAMAPiMF_00436. Hfq.
InterProiIPR005001. Hfq.
IPR010920. LSM_dom.
IPR001163. Ribonucl_LSM.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
TIGRFAMsiTIGR02383. Hfq. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiHFQ_BRUSU
AccessioniPrimary (citable) accession number: P0A3G8
Secondary accession number(s): G0KA33, Q9XBW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: July 22, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.