ID   GLGA1_AGRFC             Reviewed;         480 AA.
AC   P0A3F2; P39670;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   27-MAR-2024, entry version 89.
DE   RecName: Full=Glycogen synthase 1;
DE            EC=2.4.1.21;
DE   AltName: Full=Starch [bacterial glycogen] synthase 1;
GN   Name=glgA1; Synonyms=glgA; OrderedLocusNames=Atu4075;
GN   ORFNames=AGR_L_1562;
OS   Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens
OS   (strain C58)).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium;
OC   Agrobacterium tumefaciens complex.
OX   NCBI_TaxID=176299;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C58 / ATCC 33970;
RX   PubMed=11743193; DOI=10.1126/science.1066804;
RA   Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P., Okura V.K.,
RA   Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L., Chen Y.,
RA   Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr., Chapman P.,
RA   Clendenning J., Deatherage G., Gillet W., Grant C., Kutyavin T., Levy R.,
RA   Li M.-J., McClelland E., Palmieri A., Raymond C., Rouse G.,
RA   Saenphimmachak C., Wu Z., Romero P., Gordon D., Zhang S., Yoo H., Tao Y.,
RA   Biddle P., Jung M., Krespan W., Perry M., Gordon-Kamm B., Liao L., Kim S.,
RA   Hendrick C., Zhao Z.-Y., Dolan M., Chumley F., Tingey S.V., Tomb J.-F.,
RA   Gordon M.P., Olson M.V., Nester E.W.;
RT   "The genome of the natural genetic engineer Agrobacterium tumefaciens
RT   C58.";
RL   Science 294:2317-2323(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C58 / ATCC 33970;
RX   PubMed=11743194; DOI=10.1126/science.1066803;
RA   Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M., Qurollo B.,
RA   Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L., Houmiel K.,
RA   Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F., Wollam C., Allinger M.,
RA   Doughty D., Scott C., Lappas C., Markelz B., Flanagan C., Crowell C.,
RA   Gurson J., Lomo C., Sear C., Strub G., Cielo C., Slater S.;
RT   "Genome sequence of the plant pathogen and biotechnology agent
RT   Agrobacterium tumefaciens C58.";
RL   Science 294:2323-2328(2001).
CC   -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC         alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC         COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC         ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC   -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC       Bacterial/plant glycogen synthase subfamily. {ECO:0000305}.
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DR   EMBL; AE007870; AAK89354.1; -; Genomic_DNA.
DR   PIR; AF3057; AF3057.
DR   PIR; H98228; H98228.
DR   RefSeq; NP_356569.1; NC_003063.2.
DR   RefSeq; WP_010973546.1; NC_003063.2.
DR   AlphaFoldDB; P0A3F2; -.
DR   SMR; P0A3F2; -.
DR   STRING; 176299.Atu4075; -.
DR   CAZy; GT5; Glycosyltransferase Family 5.
DR   DNASU; 1135949; -.
DR   EnsemblBacteria; AAK89354; AAK89354; Atu4075.
DR   KEGG; atu:Atu4075; -.
DR   PATRIC; fig|176299.10.peg.3892; -.
DR   eggNOG; COG0297; Bacteria.
DR   HOGENOM; CLU_009583_18_4_5; -.
DR   OrthoDB; 9808590at2; -.
DR   PhylomeDB; P0A3F2; -.
DR   BioCyc; AGRO:ATU4075-MONOMER; -.
DR   UniPathway; UPA00164; -.
DR   Proteomes; UP000000813; Chromosome linear.
DR   GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR   GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd03791; GT5_Glycogen_synthase_DULL1-like; 1.
DR   Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR   HAMAP; MF_00484; Glycogen_synth; 1.
DR   InterPro; IPR001296; Glyco_trans_1.
DR   InterPro; IPR011835; GS/SS.
DR   InterPro; IPR013534; Starch_synth_cat_dom.
DR   NCBIfam; TIGR02095; glgA; 1.
DR   PANTHER; PTHR45825; GRANULE-BOUND STARCH SYNTHASE 1, CHLOROPLASTIC/AMYLOPLASTIC; 1.
DR   PANTHER; PTHR45825:SF11; STARCH SYNTHASE 1, CHLOROPLASTIC_AMYLOPLASTIC; 1.
DR   Pfam; PF08323; Glyco_transf_5; 1.
DR   Pfam; PF00534; Glycos_transf_1; 1.
DR   SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE   3: Inferred from homology;
KW   Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN           1..480
FT                   /note="Glycogen synthase 1"
FT                   /id="PRO_0000188584"
FT   BINDING         15
FT                   /ligand="ADP-alpha-D-glucose"
FT                   /ligand_id="ChEBI:CHEBI:57498"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   480 AA;  51709 MW;  771CF7F15FE92B83 CRC64;
     MNVLSVSSEI YPLIKTGGLA DVVGALPIAL EAHGVRTRTL IPGYPAVKAA VTDPVKCFEF
     TDLLGEKADL LEVQHERLDL LILDAPAYYE RSGGPYLGQT GKDYPDNWKR FAALSLAAAR
     IGAGVLPGWR PDMVHAHDWQ AAMTPVYMRY AETPEIPSLL TIHNIAFQGQ FGANIFSKLA
     LPAHAFGMEG IEYYNDVSFL KGGLQTATAL STVSPSYAEE ILTAEFGMGL EGVIGSRAHV
     LHGIVNGIDA DVWNPATDHL IHDNYSAANL KNRALNKKAV AEHFRIDDDG SPLFCVISRL
     TWQKGIDLMA EAVDEIVSLG GRLVVLGAGD VALEGALLAA ASRHHGRVGV AIGYNEPLSH
     LMQAGCDAII IPSRFEPCGL TQLYALRYGC IPVVARTGGL ADTVIDANHA ALASKAATGV
     QFSPVTLDGL KQAIRRTVRY YHDPKLWTQM QKLGMKSDVS WEKSAGLYAA LYSQLISKGH
//