Flavodoxin - Anabaena sp. (strain PCC 7119)

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Reviewed, UniProtKB/Swiss-Prot P0A3E0 (FLAV_ANASO)

Last modified June 16, 2009. Version 31. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
Flavodoxin

Gene names

Name:

isiB

Organism

Anabaena sp. (strain PCC 7119)

Taxonomic identifier

Taxonomic lineage

Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	170 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function

Low-potential electron donor to a number of redox enzymes.

Cofactor

FMN.

Sequence similarities

Belongs to the flavodoxin family.

Contains 1 flavodoxin-like domain.

Ontologies

Keywords
Biological process	Electron transport Transport
Ligand	FMN Flavoprotein
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Biological process	cellular response to iron ion starvation Traceable author statement. Source: UniProtKB electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FMN binding Traceable author statement. Source: UniProtKB electron carrier activity Inferred from direct assay. Source: UniProtKB oxidoreductase activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
FDXR	P08165	3	EBI-593907,EBI-593948	From a different organism.
PETH	P10933	1	EBI-593907,EBI-931306	From a different organism.
petH	P21890	5	EBI-593907,EBI-593915

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

Removed Ref.2

Chain

169

Flavodoxin

PRO_0000171600

Regions

Domain

161

Flavodoxin-like

Secondary structure

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170

Helix Strand Turn

Sequences

Sequence

Length

Mass (Da)

Tools

P0A3E0-1 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 069E8DEBA9E33302
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170

18,964

        10         20         30         40         50         60 
MSKKIGLFYG TQTGKTESVA EIIRDEFGND VVTLHDVSQA EVTDLNDYQY LIIGCPTWNI 

        70         80         90        100        110        120 
GELQSDWEGL YSELDDVDFN GKLVAYFGTG DQIGYADNFQ DAIGILEEKI SQRGGKTVGY 

       130        140        150        160        170 
WSTDGYDFND SKALRNGKFV GLALDEDNQS DLTDDRIKSW VAQLKSEFGL

References

[1]	"Isolation and overexpression in Escherichia coli of the flavodoxin gene from Anabaena PCC 7119." Fillat M.F., Borrias W.E., Weisbeek P.J. Biochem. J. 280:187-191(1991) [PubMed: 1720613] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Structural and chemical properties of a flavodoxin from Anabaena PCC 7119." Fillat M.F., Edmondson D.E., Gomez-Moreno C. Biochim. Biophys. Acta 1040:301-307(1990) [PubMed: 2119231] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-37.
[3]	"Energetics of a hydrogen bond (charged and neutral) and of a cation-pi interaction in apoflavodoxin." Fernandez-Recio J., Romero A., Sancho J. J. Mol. Biol. 290:319-330(1999) [PubMed: 10388575] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

S68006 Genomic DNA. Translation: AAB20462.1.

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1DX9	X-ray	2.05	A/B/C/D	1-170	[»]
1FTG	X-ray	2.00	A	3-169	[»]
1OBO	X-ray	1.20	A/B	3-170	[»]
1OBV	X-ray	2.10	A	3-170	[»]
1QHE	X-ray	2.00	A	3-170	[»]
2V5U	X-ray	1.99	A/B	3-169	[»]
2V5V	X-ray	1.88	A/B	3-169	[»]
3ESX	X-ray	2.31	A/B	2-170	[»]
3ESY	X-ray	2.39	A/B/C/D	2-170	[»]
3ESZ	X-ray	1.94	A/B	5-170	[»]

ModBase

Protein-protein interaction databases

IntAct

P0A3E0. 3 interactions.

Family and domain databases

InterPro

IPR008254. Flavodoxin/NO_synth.
IPR001226. Flavodoxin_CS.
IPR010086. Flavodoxin_lc.
[Graphical view]

Pfam

PF00258. Flavodoxin_1. 1 hit.
[Graphical view]

TIGRFAMs

TIGR01752. flav_long. 1 hit.

PROSITE

PS00201. FLAVODOXIN. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]

ProtoNet

Entry information

Entry name

FLAV_ANASO

Accession

Primary (citable) accession number: P0A3E0
Secondary accession number(s): P11241

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 31 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents