Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ferrochelatase

Gene

hemH

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the ferrous insertion into protoporphyrin IX.UniRule annotation

Catalytic activityi

Protoheme + 2 H+ = protoporphyrin + Fe2+.UniRule annotation

Pathwayi: protoheme biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes protoheme from protoporphyrin-IX.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Ferrochelatase (hemH)
This subpathway is part of the pathway protoheme biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes protoheme from protoporphyrin-IX, the pathway protoheme biosynthesis and in Porphyrin-containing compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi222IronUniRule annotation1
Metal bindingi303IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processHeme biosynthesis, Porphyrin biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00252; UER00325.

Names & Taxonomyi

Protein namesi
Recommended name:
FerrochelataseUniRule annotation (EC:4.99.1.1UniRule annotation)
Alternative name(s):
Heme synthaseUniRule annotation
Protoheme ferro-lyaseUniRule annotation
Gene namesi
Name:hemHUniRule annotation
Ordered Locus Names:BMEII0018
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000419 Componenti: Chromosome II

Subcellular locationi

P0A3D6:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001751211 – 352FerrochelataseAdd BLAST352

Interactioni

Protein-protein interaction databases

STRINGi224914.BAWG_1449.

Structurei

3D structure databases

ProteinModelPortaliP0A3D6.
SMRiP0A3D6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ferrochelatase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CFX. Bacteria.
COG0276. LUCA.
HOGENOMiHOG000060730.
KOiK01772.
OMAiLGDPYHC.

Family and domain databases

CDDicd00419. Ferrochelatase_C. 1 hit.
cd03411. Ferrochelatase_N. 1 hit.
HAMAPiMF_00323. Ferrochelatase. 1 hit.
InterProiView protein in InterPro
IPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
IPR033644. Ferrochelatase_C.
IPR033659. Ferrochelatase_N.
PANTHERiPTHR11108. PTHR11108. 1 hit.
PfamiView protein in Pfam
PF00762. Ferrochelatase. 1 hit.
TIGRFAMsiTIGR00109. hemH. 1 hit.
PROSITEiView protein in PROSITE
PS00534. FERROCHELATASE. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A3D6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGTDKVRVN VSQTAQTPLH TSAKLPKVGV LLVNLGTPDG TSYGPMRRYL
60 70 80 90 100
AEFLSDRRVI EWSRLIWYPI LYGIVLNTRP RRSGRLYDRI WNHENNESPL
110 120 130 140 150
RTYTRAQGEK LAKALSDQPN VVVDWAMRYG QPSIESITDR LLQQGCERIV
160 170 180 190 200
IFPLYPQYSA TTTATVNDKF FEALMKKRFM PAIRTVPSYE AEPVYIDALA
210 220 230 240 250
RSVEKHLATL SFKPEVILTS YHGIPKSYSD KGDPYRQQCL ETTRLLRERL
260 270 280 290 300
GLGEDEMRAT FQSRFGPEEW LQPYTDETVK ELAKNGVKSV AVLNPGFVAD
310 320 330 340 350
CLETVDEIGN EAAEEFLENG GENFSHIPCL NDSEEGMKVI ETLVRRELLG

WV
Length:352
Mass (Da):40,057
Last modified:March 15, 2005 - v1
Checksum:i5FE6C0F0EA435D32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008918 Genomic DNA. Translation: AAL53259.1.
PIRiAH3511.
RefSeqiWP_004681236.1. NZ_GG703779.1.

Genome annotation databases

EnsemblBacteriaiAAL53259; AAL53259; BMEII0018.
GeneIDi29595516.
KEGGibme:BMEII0018.
bmel:DK63_2101.
PATRICifig|224914.52.peg.2202.

Similar proteinsi

Entry informationi

Entry nameiHEMH_BRUME
AccessioniPrimary (citable) accession number: P0A3D6
Secondary accession number(s): Q939N8, Q93TG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: June 7, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families