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P0A393

- DHLE_BACCE

UniProt

P0A393 - DHLE_BACCE

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Protein

Leucine dehydrogenase

Gene

ldh

Organism
Bacillus cereus
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the reversible deamination of L-leucine to 4-methyl-2-oxopentanoate.1 Publication

Catalytic activityi

L-leucine + H2O + NAD+ = 4-methyl-2-oxopentanoate + NH3 + NADH.1 Publication

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei82 – 821PROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi182 – 1887NADSequence Analysis

GO - Molecular functioni

  1. leucine dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. leucine catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Branched-chain amino acid catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00363; UER00858.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine dehydrogenase (EC:1.4.1.9)
Short name:
LeuDH
Gene namesi
Name:ldh
OrganismiBacillus cereus
Taxonomic identifieri1396 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 366366Leucine dehydrogenasePRO_0000182800Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP0A393.
SMRiP0A393. Positions 3-366.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR016211. Glu/Phe/Leu/Val_DH_bac/arc.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11606:SF3. PTHR11606:SF3. 1 hit.
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000188. Phe_leu_dh. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A393-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLEIFEYLE KYDYEQVVFC QDKESGLKAI IAIHDTTLGP ALGGTRMWTY
60 70 80 90 100
DSEEAAIEDA LRLAKGMTYK NAAAGLNLGG AKTVIIGDPR KDKSEAMFRA
110 120 130 140 150
LGRYIQGLNG RYITAEDVGT TVDDMDIIHE ETDFVTGISP SFGSSGNPSP
160 170 180 190 200
VTAYGVYRGM KAAAKEAFGT DNLEGKVIAV QGVGNVAYHL CKHLHAEGAK
210 220 230 240 250
LIVTDINKEA VQRAVEEFGA SAVEPNEIYG VECDIYAPCA LGATVNDETI
260 270 280 290 300
PQLKAKVIAG SANNQLKEDR HGDIIHEMGI VYAPDYVINA GGVINVADEL
310 320 330 340 350
YGYNRERALK RVESIYDTIA KVIEISKRDG IATYVAADRL AEERIASLKN
360
SRSTYLRNGH DIISRR
Length:366
Mass (Da):39,867
Last modified:March 15, 2005 - v1
Checksum:iDA84E58062E772AC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U51099 Genomic DNA. Translation: AAA96314.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U51099 Genomic DNA. Translation: AAA96314.1 .

3D structure databases

ProteinModelPortali P0A393.
SMRi P0A393. Positions 3-366.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00363 ; UER00858 .

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR016211. Glu/Phe/Leu/Val_DH_bac/arc.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11606:SF3. PTHR11606:SF3. 1 hit.
Pfami PF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000188. Phe_leu_dh. 1 hit.
PRINTSi PR00082. GLFDHDRGNASE.
SMARTi SM00839. ELFV_dehydrog. 1 hit.
[Graphical view ]
PROSITEi PS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning, sequencing and overexpression of the leucine dehydrogenase gene from Bacillus cereus."
    Stoyan T., Recktenwald A., Kula M.R.
    J. Biotechnol. 54:77-80(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-18; 47-56; 160-192; 214-254 AND 279-298, FUNCTION, CATALYTIC ACTIVITY.
    Strain: DSM 626.

Entry informationi

Entry nameiDHLE_BACCE
AccessioniPrimary (citable) accession number: P0A393
Secondary accession number(s): Q59194
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: October 1, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3