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Protein

Leucine dehydrogenase

Gene

ldh

Organism
Bacillus cereus
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the reversible deamination of L-leucine to 4-methyl-2-oxopentanoate.1 Publication

Catalytic activityi

L-leucine + H2O + NAD+ = 4-methyl-2-oxopentanoate + NH3 + NADH.1 Publication

Pathwayi: L-leucine degradation

This protein is involved in step 1 of the subpathway that synthesizes 4-methyl-2-oxopentanoate from L-leucine (dehydrogenase route).
Proteins known to be involved in this subpathway in this organism are:
  1. Leucine dehydrogenase (ldh)
This subpathway is part of the pathway L-leucine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 4-methyl-2-oxopentanoate from L-leucine (dehydrogenase route), the pathway L-leucine degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei82PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi182 – 188NADSequence analysis7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processBranched-chain amino acid catabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00363; UER00858

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine dehydrogenase (EC:1.4.1.9)
Short name:
LeuDH
Gene namesi
Name:ldh
OrganismiBacillus cereus
Taxonomic identifieri1396 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001828001 – 366Leucine dehydrogenaseAdd BLAST366

Proteomic databases

PRIDEiP0A393

Structurei

3D structure databases

ProteinModelPortaliP0A393
SMRiP0A393
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107RDP Bacteria
COG0334 LUCA

Family and domain databases

InterProiView protein in InterPro
IPR006095 Glu/Leu/Phe/Val_DH
IPR033524 Glu/Leu/Phe/Val_DH_AS
IPR006096 Glu/Leu/Phe/Val_DH_C
IPR006097 Glu/Leu/Phe/Val_DH_dimer_dom
IPR016211 Glu/Phe/Leu/Val_DH_bac/arc
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR42722 PTHR42722, 1 hit
PfamiView protein in Pfam
PF00208 ELFV_dehydrog, 2 hits
PF02812 ELFV_dehydrog_N, 1 hit
PIRSFiPIRSF000188 Phe_leu_dh, 1 hit
PRINTSiPR00082 GLFDHDRGNASE
SMARTiView protein in SMART
SM00839 ELFV_dehydrog, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00074 GLFV_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

P0A393-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLEIFEYLE KYDYEQVVFC QDKESGLKAI IAIHDTTLGP ALGGTRMWTY
60 70 80 90 100
DSEEAAIEDA LRLAKGMTYK NAAAGLNLGG AKTVIIGDPR KDKSEAMFRA
110 120 130 140 150
LGRYIQGLNG RYITAEDVGT TVDDMDIIHE ETDFVTGISP SFGSSGNPSP
160 170 180 190 200
VTAYGVYRGM KAAAKEAFGT DNLEGKVIAV QGVGNVAYHL CKHLHAEGAK
210 220 230 240 250
LIVTDINKEA VQRAVEEFGA SAVEPNEIYG VECDIYAPCA LGATVNDETI
260 270 280 290 300
PQLKAKVIAG SANNQLKEDR HGDIIHEMGI VYAPDYVINA GGVINVADEL
310 320 330 340 350
YGYNRERALK RVESIYDTIA KVIEISKRDG IATYVAADRL AEERIASLKN
360
SRSTYLRNGH DIISRR
Length:366
Mass (Da):39,867
Last modified:March 15, 2005 - v1
Checksum:iDA84E58062E772AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51099 Genomic DNA Translation: AAA96314.1
RefSeqiWP_000171355.1, NZ_NVMY01000059.1

Genome annotation databases

GeneIDi29685047

Similar proteinsi

Entry informationi

Entry nameiDHLE_BACCE
AccessioniPrimary (citable) accession number: P0A393
Secondary accession number(s): Q59194
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

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