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P0A393

- DHLE_BACCE

UniProt

P0A393 - DHLE_BACCE

Protein

Leucine dehydrogenase

Gene

ldh

Organism
Bacillus cereus
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible deamination of L-leucine to 4-methyl-2-oxopentanoate.1 Publication

    Catalytic activityi

    L-leucine + H2O + NAD+ = 4-methyl-2-oxopentanoate + NH3 + NADH.1 Publication

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei82 – 821PROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi182 – 1887NADSequence Analysis

    GO - Molecular functioni

    1. leucine dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. leucine catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Branched-chain amino acid catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00363; UER00858.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine dehydrogenase (EC:1.4.1.9)
    Short name:
    LeuDH
    Gene namesi
    Name:ldh
    OrganismiBacillus cereus
    Taxonomic identifieri1396 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 366366Leucine dehydrogenasePRO_0000182800Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP0A393.
    SMRiP0A393. Positions 3-366.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR006095. Glu/Leu/Phe/Val_DH.
    IPR006096. Glu/Leu/Phe/Val_DH_C.
    IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
    IPR016211. Glu/Phe/Leu/Val_DH_bac/arc.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11606:SF3. PTHR11606:SF3. 1 hit.
    PfamiPF00208. ELFV_dehydrog. 1 hit.
    PF02812. ELFV_dehydrog_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000188. Phe_leu_dh. 1 hit.
    PRINTSiPR00082. GLFDHDRGNASE.
    SMARTiSM00839. ELFV_dehydrog. 1 hit.
    [Graphical view]
    PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0A393-1 [UniParc]FASTAAdd to Basket

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    MTLEIFEYLE KYDYEQVVFC QDKESGLKAI IAIHDTTLGP ALGGTRMWTY    50
    DSEEAAIEDA LRLAKGMTYK NAAAGLNLGG AKTVIIGDPR KDKSEAMFRA 100
    LGRYIQGLNG RYITAEDVGT TVDDMDIIHE ETDFVTGISP SFGSSGNPSP 150
    VTAYGVYRGM KAAAKEAFGT DNLEGKVIAV QGVGNVAYHL CKHLHAEGAK 200
    LIVTDINKEA VQRAVEEFGA SAVEPNEIYG VECDIYAPCA LGATVNDETI 250
    PQLKAKVIAG SANNQLKEDR HGDIIHEMGI VYAPDYVINA GGVINVADEL 300
    YGYNRERALK RVESIYDTIA KVIEISKRDG IATYVAADRL AEERIASLKN 350
    SRSTYLRNGH DIISRR 366
    Length:366
    Mass (Da):39,867
    Last modified:March 15, 2005 - v1
    Checksum:iDA84E58062E772AC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U51099 Genomic DNA. Translation: AAA96314.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U51099 Genomic DNA. Translation: AAA96314.1 .

    3D structure databases

    ProteinModelPortali P0A393.
    SMRi P0A393. Positions 3-366.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00363 ; UER00858 .

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR006095. Glu/Leu/Phe/Val_DH.
    IPR006096. Glu/Leu/Phe/Val_DH_C.
    IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
    IPR016211. Glu/Phe/Leu/Val_DH_bac/arc.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11606:SF3. PTHR11606:SF3. 1 hit.
    Pfami PF00208. ELFV_dehydrog. 1 hit.
    PF02812. ELFV_dehydrog_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000188. Phe_leu_dh. 1 hit.
    PRINTSi PR00082. GLFDHDRGNASE.
    SMARTi SM00839. ELFV_dehydrog. 1 hit.
    [Graphical view ]
    PROSITEi PS00074. GLFV_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, sequencing and overexpression of the leucine dehydrogenase gene from Bacillus cereus."
      Stoyan T., Recktenwald A., Kula M.R.
      J. Biotechnol. 54:77-80(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-18; 47-56; 160-192; 214-254 AND 279-298, FUNCTION, CATALYTIC ACTIVITY.
      Strain: DSM 626.

    Entry informationi

    Entry nameiDHLE_BACCE
    AccessioniPrimary (citable) accession number: P0A393
    Secondary accession number(s): Q59194
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3