ID   NAHF_PSEU8              Reviewed;         483 AA.
AC   P0A390; O34269; Q52460;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   16-JUN-2009, entry version 19.
DE   RecName: Full=Salicylaldehyde dehydrogenase;
DE            EC=1.2.1.65;
GN   Name=doxF;
OS   Pseudomonas sp. (strain C18).
OG   Plasmid.
OC   Bacteria; Proteobacteria.
OX   NCBI_TaxID=69011;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=94042852; PubMed=8226631;
RA   Denome S.A., Stanley D.C., Olson E.S., Young K.D.;
RT   "Metabolism of dibenzothiophene and naphthalene in Pseudomonas
RT   strains: complete DNA sequence of an upper naphthalene catabolic
RT   pathway.";
RL   J. Bacteriol. 175:6890-6901(1993).
CC   -!- CATALYTIC ACTIVITY: Salicylaldehyde + NAD(+) + H(2)O = salicylate
CC       + NADH.
CC   -!- PATHWAY: Aromatic compound metabolism; naphtalene degradation.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
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DR   EMBL; M60405; AAA16129.1; -; Genomic_DNA.
DR   HSSP; Q63639; 1BI9.
DR   GO; GO:0018485; F:salicylaldehyde dehydrogenase activity; IEA:EC.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR016160; Ald_DH_CS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; FALSE_NEG.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Aromatic hydrocarbons catabolism; NAD; Oxidoreductase; Plasmid.
FT   CHAIN         1    483       Salicylaldehyde dehydrogenase.
FT                                /FTId=PRO_0000056590.
FT   NP_BIND     228    233       NAD (By similarity).
FT   ACT_SITE    250    250       By similarity.
FT   ACT_SITE    284    284       By similarity.
SQ   SEQUENCE   483 AA;  51994 MW;  CD606BADD21DFACE CRC64;
     MKTKLFINNA WIDSSDQQTF ERIHPVSSDV VTESANATVT DAIKAAQAAE EAFKTWKAVG
     PSERRRLLLK VADVMESKTP KFIEVMAMEV GASALWAGFN VHASANVFRE AASLATQIQG
     ETIPTDKAET LSMTLRQPVG PILSIVPWNG TAVLAARAIA YPLVCGNTVV FKGSEFSPAT
     HALITQCVQE AGLPAGVLNY LNSSPDRSPE IADALISAKE IRRINFTGST RVGSIIAQKA
     AQHLKRCLLE LGGKSPLIVL DDADIDAAVK AAVFGSFLFQ GQICMSTERL IVDEKIADEF
     VAKFVEKTKR LSAGDPCVTG DCIIGPMVSP NSGERINGLF KDAIDKGAKV VCGGLAQGAL
     MPATILDHVK SDMRIYDEET FGPITVVIRC KGEAEAVRIA NDSVYGLSSG VFGRDINRAL
     RVGMSIEYGS VHINGSTVQN EAQAPYGGTK NTGYGRFDGR AVIDEFTEIK WLTIEPFEQQ
     YPF
//