P0A390 (NAHF_PSEU8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Salicylaldehyde dehydrogenase
EC=1.2.1.65

Gene names

Name:

doxF

Encoded on

Plasmid

Organism

Pseudomonas sp. (strain C18)

Taxonomic identifier

69011 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria

Protein attributes

Sequence length	483 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Salicylaldehyde + NAD+ + H2O = salicylate + NADH.
Pathway	Aromatic compound metabolism; naphthalene degradation.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Plasmid
Gene Ontology (GO)
Biological process	aromatic compound catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	salicylaldehyde dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 483	483	Salicylaldehyde dehydrogenase		PRO_0000056590
Regions
	Nucleotide binding	228 – 233	6	NAD By similarity
Sites
	Active site	250	1	By similarity
	Active site	284	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0A390 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: CD606BADD21DFACE	FASTA	483	51,994
	10 20 30 40 50 60 MKTKLFINNA WIDSSDQQTF ERIHPVSSDV VTESANATVT DAIKAAQAAE EAFKTWKAVG 70 80 90 100 110 120 PSERRRLLLK VADVMESKTP KFIEVMAMEV GASALWAGFN VHASANVFRE AASLATQIQG 130 140 150 160 170 180 ETIPTDKAET LSMTLRQPVG PILSIVPWNG TAVLAARAIA YPLVCGNTVV FKGSEFSPAT 190 200 210 220 230 240 HALITQCVQE AGLPAGVLNY LNSSPDRSPE IADALISAKE IRRINFTGST RVGSIIAQKA 250 260 270 280 290 300 AQHLKRCLLE LGGKSPLIVL DDADIDAAVK AAVFGSFLFQ GQICMSTERL IVDEKIADEF 310 320 330 340 350 360 VAKFVEKTKR LSAGDPCVTG DCIIGPMVSP NSGERINGLF KDAIDKGAKV VCGGLAQGAL 370 380 390 400 410 420 MPATILDHVK SDMRIYDEET FGPITVVIRC KGEAEAVRIA NDSVYGLSSG VFGRDINRAL 430 440 450 460 470 480 RVGMSIEYGS VHINGSTVQN EAQAPYGGTK NTGYGRFDGR AVIDEFTEIK WLTIEPFEQQ YPF

References

[1]	"Metabolism of dibenzothiophene and naphthalene in Pseudomonas strains: complete DNA sequence of an upper naphthalene catabolic pathway." Denome S.A., Stanley D.C., Olson E.S., Young K.D. J. Bacteriol. 175:6890-6901(1993) [PubMed: 8226631] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M60405 Genomic DNA. Translation: AAA16129.1.
3D structure databases
ProteinModelPortal	P0A390.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. False negative. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NAHF_PSEU8

Accession

Primary (citable) accession number: P0A390
Secondary accession number(s): O34269, Q52460

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	March 15, 2005
Last modified:	June 28, 2011
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program