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Protein

Type-1Aa cytolytic delta-endotoxin

Gene

cyt1Aa

Organism
Bacillus thuringiensis subsp. israelensis
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Kills the larvae of dipteran insects by making pores in the epithelial cell membrane of the insect midgut. Acts on mosquitos and black flies.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionToxin
Biological processSporulation

Protein family/group databases

TCDBi1.C.71.1.1 the cytolytic delta endotoxin (cyt1/2) family

Names & Taxonomyi

Protein namesi
Recommended name:
Type-1Aa cytolytic delta-endotoxin
Alternative name(s):
27 kDa cytolytic toxin
Gene namesi
Name:cyt1Aa
Synonyms:cytA
Encoded oniPlasmid 72 Kb0 Publication
OrganismiBacillus thuringiensis subsp. israelensis
Taxonomic identifieri1430 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001741041 – 249Type-1Aa cytolytic delta-endotoxinAdd BLAST249

Post-translational modificationi

Active after proteolytic processing.

Expressioni

Developmental stagei

The crystal protein is produced during sporulation and is accumulated both as an inclusion and as part of the spore coat.

Structurei

Secondary structure

1249
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi40 – 47Combined sources8
Helixi49 – 51Combined sources3
Helixi52 – 62Combined sources11
Helixi63 – 65Combined sources3
Beta strandi66 – 68Combined sources3
Turni71 – 73Combined sources3
Beta strandi77 – 79Combined sources3
Helixi81 – 90Combined sources10
Beta strandi96 – 111Combined sources16
Helixi112 – 127Combined sources16
Helixi129 – 134Combined sources6
Helixi136 – 147Combined sources12
Helixi151 – 153Combined sources3
Beta strandi159 – 165Combined sources7
Beta strandi168 – 181Combined sources14
Turni182 – 186Combined sources5
Beta strandi187 – 201Combined sources15
Helixi203 – 206Combined sources4
Beta strandi214 – 229Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J2Lmodel-A18-249[»]
3RONX-ray2.19A/B1-249[»]
ProteinModelPortaliP0A382
SMRiP0A382
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A382

Family & Domainsi

Sequence similaritiesi

Belongs to the cyt1/cyt2 endotoxin family.Curated

Family and domain databases

Gene3Di3.40.198.10, 1 hit
InterProiView protein in InterPro
IPR035918 CytB_endotoxin-like_sf
IPR001615 Endotoxin_CytB
PfamiView protein in Pfam
PF01338 Bac_thur_toxin, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD009844 Endotoxin_CytB, 1 hit
SUPFAMiSSF55676 SSF55676, 1 hit

Sequencei

Sequence statusi: Complete.

P0A382-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENLNHCPLE DIKVNPWKTP QSTARVITLR VEDPNEINNL LSINEIDNPN
60 70 80 90 100
YILQAIMLAN AFQNALVPTS TDFGDALRFS MPKGLEIANT ITPMGAVVSY
110 120 130 140 150
VDQNVTQTNN QVSVMINKVL EVLKTVLGVA LSGSVIDQLT AAVTNTFTNL
160 170 180 190 200
NTQKNEAWIF WGKETANQTN YTYNVLFAIQ NAQTGGVMYC VPVGFEIKVS
210 220 230 240
AVKEQVLFFT IQDSASYNVN IQSLKFAQPL VSSSQYPIAD LTSAINGTL
Length:249
Mass (Da):27,341
Last modified:August 13, 1987 - v1
Checksum:iE661946298D3989A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04338 Genomic DNA Translation: CAA27868.1
X03182 Genomic DNA Translation: CAA26943.1
PIRiA24044
RefSeqiWP_000429377.1, NZ_PGDS01000470.1

Similar proteinsi

Entry informationi

Entry nameiCT1AA_BACTI
AccessioniPrimary (citable) accession number: P0A382
Secondary accession number(s): P05069, P05628
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: May 23, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Plasmid

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