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Protein

Type-1Aa cytolytic delta-endotoxin

Gene

cyt1Aa

Organism
Bacillus thuringiensis subsp. israelensis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Kills the larvae of dipteran insects by making pores in the epithelial cell membrane of the insect midgut. Acts on mosquitos and black flies.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Toxin

Keywords - Biological processi

Sporulation

Protein family/group databases

TCDBi1.C.71.1.1. the cytolytic delta endotoxin (cyt1/2) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Type-1Aa cytolytic delta-endotoxin
Alternative name(s):
27 kDa cytolytic toxin
Gene namesi
Name:cyt1Aa
Synonyms:cytA
Encoded oniPlasmid 72 Kb0 Publication
OrganismiBacillus thuringiensis subsp. israelensis
Taxonomic identifieri1430 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001741041 – 249Type-1Aa cytolytic delta-endotoxinAdd BLAST249

Post-translational modificationi

Active after proteolytic processing.

Expressioni

Developmental stagei

The crystal protein is produced during sporulation and is accumulated both as an inclusion and as part of the spore coat.

Structurei

Secondary structure

1249
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi40 – 47Combined sources8
Helixi49 – 51Combined sources3
Helixi52 – 62Combined sources11
Helixi63 – 65Combined sources3
Beta strandi66 – 68Combined sources3
Turni71 – 73Combined sources3
Beta strandi77 – 79Combined sources3
Helixi81 – 90Combined sources10
Beta strandi96 – 111Combined sources16
Helixi112 – 127Combined sources16
Helixi129 – 134Combined sources6
Helixi136 – 147Combined sources12
Helixi151 – 153Combined sources3
Beta strandi159 – 165Combined sources7
Beta strandi168 – 181Combined sources14
Turni182 – 186Combined sources5
Beta strandi187 – 201Combined sources15
Helixi203 – 206Combined sources4
Beta strandi214 – 229Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J2Lmodel-A18-249[»]
3RONX-ray2.19A/B1-249[»]
ProteinModelPortaliP0A382.
SMRiP0A382.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A382.

Family & Domainsi

Sequence similaritiesi

Belongs to the cyt1/cyt2 endotoxin family.Curated

Family and domain databases

Gene3Di3.40.198.10. 1 hit.
InterProiIPR001615. Endotoxin_CytB.
[Graphical view]
PfamiPF01338. Bac_thur_toxin. 1 hit.
[Graphical view]
ProDomiPD009844. Endotoxin_CytB. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF55676. SSF55676. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A382-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENLNHCPLE DIKVNPWKTP QSTARVITLR VEDPNEINNL LSINEIDNPN
60 70 80 90 100
YILQAIMLAN AFQNALVPTS TDFGDALRFS MPKGLEIANT ITPMGAVVSY
110 120 130 140 150
VDQNVTQTNN QVSVMINKVL EVLKTVLGVA LSGSVIDQLT AAVTNTFTNL
160 170 180 190 200
NTQKNEAWIF WGKETANQTN YTYNVLFAIQ NAQTGGVMYC VPVGFEIKVS
210 220 230 240
AVKEQVLFFT IQDSASYNVN IQSLKFAQPL VSSSQYPIAD LTSAINGTL
Length:249
Mass (Da):27,341
Last modified:August 13, 1987 - v1
Checksum:iE661946298D3989A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04338 Genomic DNA. Translation: CAA27868.1.
X03182 Genomic DNA. Translation: CAA26943.1.
PIRiA24044.
RefSeqiWP_000429377.1. NC_010076.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04338 Genomic DNA. Translation: CAA27868.1.
X03182 Genomic DNA. Translation: CAA26943.1.
PIRiA24044.
RefSeqiWP_000429377.1. NC_010076.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J2Lmodel-A18-249[»]
3RONX-ray2.19A/B1-249[»]
ProteinModelPortaliP0A382.
SMRiP0A382.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi1.C.71.1.1. the cytolytic delta endotoxin (cyt1/2) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP0A382.

Family and domain databases

Gene3Di3.40.198.10. 1 hit.
InterProiIPR001615. Endotoxin_CytB.
[Graphical view]
PfamiPF01338. Bac_thur_toxin. 1 hit.
[Graphical view]
ProDomiPD009844. Endotoxin_CytB. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF55676. SSF55676. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCT1AA_BACTI
AccessioniPrimary (citable) accession number: P0A382
Secondary accession number(s): P05069, P05628
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 13, 1987
Last modified: November 2, 2016
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Plasmid

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.