ID CR1AA_BACTK Reviewed; 1176 AA. AC P0A366; P02965; P09664; P09665; P16478; Q9RED5; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 15-MAR-2005, sequence version 1. DT 24-JAN-2024, entry version 74. DE RecName: Full=Pesticidal crystal protein Cry1Aa; DE AltName: Full=133 kDa crystal protein; DE AltName: Full=Crystaline entomocidal protoxin; DE AltName: Full=Insecticidal delta-endotoxin CryIA(a); GN Name=cry1Aa; GN Synonyms=cry-1-1, cry1A(a), cryA, crybns3-1, cryIA(a), icp; OS Bacillus thuringiensis subsp. kurstaki. OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus; OC Bacillus cereus group. OX NCBI_TaxID=29339; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=HD-1; RX PubMed=2581950; DOI=10.1016/s0021-9258(18)88966-9; RA Schnepf H.E., Wong H.C., Whiteley H.R.; RT "The amino acid sequence of a crystal protein from Bacillus thuringiensis RT deduced from the DNA base sequence."; RL J. Biol. Chem. 260:6264-6272(1985). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=BNS3; RA Tounsi S., J'Mal A., Zouari N., Jaoua S.; RT "Cloning and nucleotide sequence of a novel cry1Aa-type gene from Bacillus RT thuringiensis subsp.kurstaki."; RL Biotechnol. Lett. 21:771-775(1999). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-333, AND PROTEIN SEQUENCE OF 1-9. RC STRAIN=HD-1; RX PubMed=6296116; DOI=10.1016/s0021-9258(18)33082-5; RA Wong H.C., Schnepf H.E., Whiteley H.R.; RT "Transcriptional and translational start sites for the Bacillus RT thuringiensis crystal protein gene."; RL J. Biol. Chem. 258:1960-1967(1983). RN [4] RP X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 33-609. RC STRAIN=HD-1; RX PubMed=7490762; DOI=10.1006/jmbi.1995.0630; RA Grochulski P., Masson L., Borisova S., Pusztai-Carey M., Schwartz J.L., RA Brousseau R., Cygler M.; RT "Bacillus thuringiensis CryIA(a) insecticidal toxin: crystal structure and RT channel formation."; RL J. Mol. Biol. 254:447-464(1995). CC -!- FUNCTION: Promotes colloidosmotic lysis by binding to the midgut CC epithelial cells of many lepidopteran larvae. CC -!- INTERACTION: CC P0A366; Q9XY09: btr175; Xeno; NbExp=10; IntAct=EBI-7210432, EBI-7210462; CC -!- DEVELOPMENTAL STAGE: The crystal protein is produced during sporulation CC and is accumulated both as an inclusion and as part of the spore coat. CC -!- MISCELLANEOUS: Toxic segment of the protein is located in the N- CC terminus. CC -!- SIMILARITY: Belongs to the delta endotoxin family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M11250; AAA22353.1; -; Genomic_DNA. DR EMBL; Y09663; CAA70856.1; -; mRNA. DR EMBL; J01554; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PIR; A22617; A22617. DR PDB; 1CIY; X-ray; 2.25 A; A=29-618. DR PDBsum; 1CIY; -. DR AlphaFoldDB; P0A366; -. DR SMR; P0A366; -. DR IntAct; P0A366; 1. DR MINT; P0A366; -. DR EvolutionaryTrace; P0A366; -. DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro. DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW. DR GO; GO:0001907; P:killing by symbiont of host cells; IEA:InterPro. DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW. DR CDD; cd04085; delta_endotoxin_C; 1. DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 2. DR Gene3D; 2.100.10.10; Pesticidal crystal protein, central domain; 1. DR Gene3D; 1.20.190.10; Pesticidal crystal protein, N-terminal domain; 1. DR InterPro; IPR048645; Cry1Ac-like_dom-VII. DR InterPro; IPR041587; Cry_V. DR InterPro; IPR008979; Galactose-bd-like_sf. DR InterPro; IPR038979; Pest_crys. DR InterPro; IPR005638; Pest_crys_C. DR InterPro; IPR005639; Pest_crys_N. DR InterPro; IPR036716; Pest_crys_N_sf. DR InterPro; IPR001178; Pest_cryst_cen_dom. DR InterPro; IPR036399; Pest_cryst_cen_dom_sf. DR PANTHER; PTHR37003:SF2; ENDOTOXIN_N DOMAIN-CONTAINING PROTEIN; 1. DR PANTHER; PTHR37003; ENDOTOXIN_N DOMAIN-CONTAINING PROTEIN-RELATED; 1. DR Pfam; PF17997; Cry1Ac_D5; 1. DR Pfam; PF21463; Cry1Ac_dom-VII; 1. DR Pfam; PF03944; Endotoxin_C; 1. DR Pfam; PF18449; Endotoxin_C2; 1. DR Pfam; PF00555; Endotoxin_M; 1. DR Pfam; PF03945; Endotoxin_N; 1. DR SUPFAM; SSF51096; delta-Endotoxin (insectocide), middle domain; 1. DR SUPFAM; SSF56849; delta-Endotoxin (insectocide), N-terminal domain; 1. DR SUPFAM; SSF49785; Galactose-binding domain-like; 1. PE 1: Evidence at protein level; KW 3D-structure; Direct protein sequencing; Sporulation; Toxin; Virulence. FT CHAIN 1..1176 FT /note="Pesticidal crystal protein Cry1Aa" FT /id="PRO_0000174019" FT VARIANT 77 FT /note="P -> L (in strain: BNS3)" FT CONFLICT 1009 FT /note="V -> L (in Ref. 1; AAA22353)" FT /evidence="ECO:0000305" FT HELIX 35..48 FT /evidence="ECO:0007829|PDB:1CIY" FT STRAND 51..53 FT /evidence="ECO:0007829|PDB:1CIY" FT HELIX 54..63 FT /evidence="ECO:0007829|PDB:1CIY" FT HELIX 70..84 FT /evidence="ECO:0007829|PDB:1CIY" FT HELIX 90..119 FT /evidence="ECO:0007829|PDB:1CIY" FT HELIX 124..144 FT /evidence="ECO:0007829|PDB:1CIY" FT HELIX 145..148 FT /evidence="ECO:0007829|PDB:1CIY" FT HELIX 154..178 FT /evidence="ECO:0007829|PDB:1CIY" FT HELIX 180..182 FT /evidence="ECO:0007829|PDB:1CIY" FT HELIX 186..218 FT /evidence="ECO:0007829|PDB:1CIY" FT HELIX 223..239 FT /evidence="ECO:0007829|PDB:1CIY" FT HELIX 241..244 FT /evidence="ECO:0007829|PDB:1CIY" FT HELIX 245..250 FT /evidence="ECO:0007829|PDB:1CIY" FT TURN 252..254 FT /evidence="ECO:0007829|PDB:1CIY" FT STRAND 266..269 FT /evidence="ECO:0007829|PDB:1CIY" FT HELIX 271..274 FT /evidence="ECO:0007829|PDB:1CIY" FT HELIX 284..289 FT /evidence="ECO:0007829|PDB:1CIY" FT STRAND 298..310 FT /evidence="ECO:0007829|PDB:1CIY" FT STRAND 313..325 FT /evidence="ECO:0007829|PDB:1CIY" FT HELIX 326..328 FT /evidence="ECO:0007829|PDB:1CIY" FT STRAND 344..351 FT /evidence="ECO:0007829|PDB:1CIY" FT STRAND 357..367 FT /evidence="ECO:0007829|PDB:1CIY" FT STRAND 380..390 FT /evidence="ECO:0007829|PDB:1CIY" FT STRAND 393..395 FT /evidence="ECO:0007829|PDB:1CIY" FT STRAND 400..403 FT /evidence="ECO:0007829|PDB:1CIY" FT STRAND 407..409 FT /evidence="ECO:0007829|PDB:1CIY" FT HELIX 410..412 FT /evidence="ECO:0007829|PDB:1CIY" FT HELIX 423..426 FT /evidence="ECO:0007829|PDB:1CIY" FT STRAND 429..434 FT /evidence="ECO:0007829|PDB:1CIY" FT STRAND 444..449 FT /evidence="ECO:0007829|PDB:1CIY" FT STRAND 452..456 FT /evidence="ECO:0007829|PDB:1CIY" FT STRAND 467..474 FT /evidence="ECO:0007829|PDB:1CIY" FT HELIX 475..477 FT /evidence="ECO:0007829|PDB:1CIY" FT STRAND 479..481 FT /evidence="ECO:0007829|PDB:1CIY" FT STRAND 486..488 FT /evidence="ECO:0007829|PDB:1CIY" FT STRAND 492..496 FT /evidence="ECO:0007829|PDB:1CIY" FT STRAND 498..514 FT /evidence="ECO:0007829|PDB:1CIY" FT STRAND 522..532 FT /evidence="ECO:0007829|PDB:1CIY" FT STRAND 534..540 FT /evidence="ECO:0007829|PDB:1CIY" FT STRAND 543..550 FT /evidence="ECO:0007829|PDB:1CIY" FT HELIX 562..564 FT /evidence="ECO:0007829|PDB:1CIY" FT STRAND 566..569 FT /evidence="ECO:0007829|PDB:1CIY" FT STRAND 577..590 FT /evidence="ECO:0007829|PDB:1CIY" FT STRAND 596..605 FT /evidence="ECO:0007829|PDB:1CIY" SQ SEQUENCE 1176 AA; 133120 MW; E2EE15AF12E5DD85 CRC64; MDNNPNINEC IPYNCLSNPE VEVLGGERIE TGYTPIDISL SLTQFLLSEF VPGAGFVLGL VDIIWGIFGP SQWDAFPVQI EQLINQRIEE FARNQAISRL EGLSNLYQIY AESFREWEAD PTNPALREEM RIQFNDMNSA LTTAIPLLAV QNYQVPLLSV YVQAANLHLS VLRDVSVFGQ RWGFDAATIN SRYNDLTRLI GNYTDYAVRW YNTGLERVWG PDSRDWVRYN QFRRELTLTV LDIVALFSNY DSRRYPIRTV SQLTREIYTN PVLENFDGSF RGMAQRIEQN IRQPHLMDIL NSITIYTDVH RGFNYWSGHQ ITASPVGFSG PEFAFPLFGN AGNAAPPVLV SLTGLGIFRT LSSPLYRRII LGSGPNNQEL FVLDGTEFSF ASLTTNLPST IYRQRGTVDS LDVIPPQDNS VPPRAGFSHR LSHVTMLSQA AGAVYTLRAP TFSWQHRSAE FNNIIPSSQI TQIPLTKSTN LGSGTSVVKG PGFTGGDILR RTSPGQISTL RVNITAPLSQ RYRVRIRYAS TTNLQFHTSI DGRPINQGNF SATMSSGSNL QSGSFRTVGF TTPFNFSNGS SVFTLSAHVF NSGNEVYIDR IEFVPAEVTF EAEYDLERAQ KAVNELFTSS NQIGLKTDVT DYHIDQVSNL VECLSDEFCL DEKQELSEKV KHAKRLSDER NLLQDPNFRG INRQLDRGWR GSTDITIQGG DDVFKENYVT LLGTFDECYP TYLYQKIDES KLKAYTRYQL RGYIEDSQDL EIYLIRYNAK HETVNVPGTG SLWPLSAQSP IGKCGEPNRC APHLEWNPDL DCSCRDGEKC AHHSHHFSLD IDVGCTDLNE DLGVWVIFKI KTQDGHARLG NLEFLEEKPL VGEALARVKR AEKKWRDKRE KLEWETNIVY KEAKESVDAL FVNSQYDQLQ ADTNIAMIHA ADKRVHSIRE AYLPELSVIP GVNAAIFEEL EGRIFTAFSL YDARNVIKNG DFNNGLSCWN VKGHVDVEEQ NNQRSVLVVP EWEAEVSQEV RVCPGRGYIL RVTAYKEGYG EGCVTIHEIE NNTDELKFSN CVEEEIYPNN TVTCNDYTVN QEEYGGAYTS RNRGYNEAPS VPADYASVYE EKSYTDGRRE NPCEFNRGYR DYTPLPVGYV TKELEYFPET DKVWIEIGET EGTFIVDSVE LLLMEE //