Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pesticidal crystal protein Cry1Aa

Gene

cry1Aa

Organism
Bacillus thuringiensis subsp. kurstaki
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes colloidosmotic lysis by binding to the midgut epithelial cells of many lepidopteran larvae.

Miscellaneous

Toxic segment of the protein is located in the N-terminus.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionToxin
Biological processSporulation

Names & Taxonomyi

Protein namesi
Recommended name:
Pesticidal crystal protein Cry1Aa
Alternative name(s):
133 kDa crystal protein
Crystaline entomocidal protoxin
Insecticidal delta-endotoxin CryIA(a)
Gene namesi
Name:cry1Aa
Synonyms:cry-1-1, cry1A(a), cryA, crybns3-1, cryIA(a), icp
OrganismiBacillus thuringiensis subsp. kurstaki
Taxonomic identifieri29339 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001740191 – 1176Pesticidal crystal protein Cry1AaAdd BLAST1176

Expressioni

Developmental stagei

The crystal protein is produced during sporulation and is accumulated both as an inclusion and as part of the spore coat.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
btr175Q9XY0910EBI-7210432,EBI-7210462From Bombyx mori.

GO - Molecular functioni

Protein-protein interaction databases

IntActiP0A366, 1 interactor
MINTiP0A366

Structurei

Secondary structure

11176
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi35 – 48Combined sources14
Beta strandi51 – 53Combined sources3
Helixi54 – 63Combined sources10
Helixi70 – 84Combined sources15
Helixi90 – 119Combined sources30
Helixi124 – 144Combined sources21
Helixi145 – 148Combined sources4
Helixi154 – 178Combined sources25
Helixi180 – 182Combined sources3
Helixi186 – 218Combined sources33
Helixi223 – 239Combined sources17
Helixi241 – 244Combined sources4
Helixi245 – 250Combined sources6
Turni252 – 254Combined sources3
Beta strandi266 – 269Combined sources4
Helixi271 – 274Combined sources4
Helixi284 – 289Combined sources6
Beta strandi298 – 310Combined sources13
Beta strandi313 – 325Combined sources13
Helixi326 – 328Combined sources3
Beta strandi344 – 351Combined sources8
Beta strandi357 – 367Combined sources11
Beta strandi380 – 390Combined sources11
Beta strandi393 – 395Combined sources3
Beta strandi400 – 403Combined sources4
Beta strandi407 – 409Combined sources3
Helixi410 – 412Combined sources3
Helixi423 – 426Combined sources4
Beta strandi429 – 434Combined sources6
Beta strandi444 – 449Combined sources6
Beta strandi452 – 456Combined sources5
Beta strandi467 – 474Combined sources8
Helixi475 – 477Combined sources3
Beta strandi479 – 481Combined sources3
Beta strandi486 – 488Combined sources3
Beta strandi492 – 496Combined sources5
Beta strandi498 – 514Combined sources17
Beta strandi522 – 532Combined sources11
Beta strandi534 – 540Combined sources7
Beta strandi543 – 550Combined sources8
Helixi562 – 564Combined sources3
Beta strandi566 – 569Combined sources4
Beta strandi577 – 590Combined sources14
Beta strandi596 – 605Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CIYX-ray2.25A29-618[»]
ProteinModelPortaliP0A366
SMRiP0A366
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A366

Family & Domainsi

Sequence similaritiesi

Belongs to the delta endotoxin family.Curated

Family and domain databases

Gene3Di1.20.190.10, 1 hit
2.100.10.10, 1 hit
2.60.120.260, 3 hits
InterProiView protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR005638 Pest_crys_C
IPR005639 Pest_crys_N
IPR036716 Pest_crys_N_sf
IPR001178 Pest_cryst_cen_dom
IPR036399 Pest_cryst_cen_dom_sf
PfamiView protein in Pfam
PF03944 Endotoxin_C, 1 hit
PF00555 Endotoxin_M, 1 hit
PF03945 Endotoxin_N, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
SSF51096 SSF51096, 1 hit
SSF56849 SSF56849, 1 hit

Sequencei

Sequence statusi: Complete.

P0A366-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNNPNINEC IPYNCLSNPE VEVLGGERIE TGYTPIDISL SLTQFLLSEF
60 70 80 90 100
VPGAGFVLGL VDIIWGIFGP SQWDAFPVQI EQLINQRIEE FARNQAISRL
110 120 130 140 150
EGLSNLYQIY AESFREWEAD PTNPALREEM RIQFNDMNSA LTTAIPLLAV
160 170 180 190 200
QNYQVPLLSV YVQAANLHLS VLRDVSVFGQ RWGFDAATIN SRYNDLTRLI
210 220 230 240 250
GNYTDYAVRW YNTGLERVWG PDSRDWVRYN QFRRELTLTV LDIVALFSNY
260 270 280 290 300
DSRRYPIRTV SQLTREIYTN PVLENFDGSF RGMAQRIEQN IRQPHLMDIL
310 320 330 340 350
NSITIYTDVH RGFNYWSGHQ ITASPVGFSG PEFAFPLFGN AGNAAPPVLV
360 370 380 390 400
SLTGLGIFRT LSSPLYRRII LGSGPNNQEL FVLDGTEFSF ASLTTNLPST
410 420 430 440 450
IYRQRGTVDS LDVIPPQDNS VPPRAGFSHR LSHVTMLSQA AGAVYTLRAP
460 470 480 490 500
TFSWQHRSAE FNNIIPSSQI TQIPLTKSTN LGSGTSVVKG PGFTGGDILR
510 520 530 540 550
RTSPGQISTL RVNITAPLSQ RYRVRIRYAS TTNLQFHTSI DGRPINQGNF
560 570 580 590 600
SATMSSGSNL QSGSFRTVGF TTPFNFSNGS SVFTLSAHVF NSGNEVYIDR
610 620 630 640 650
IEFVPAEVTF EAEYDLERAQ KAVNELFTSS NQIGLKTDVT DYHIDQVSNL
660 670 680 690 700
VECLSDEFCL DEKQELSEKV KHAKRLSDER NLLQDPNFRG INRQLDRGWR
710 720 730 740 750
GSTDITIQGG DDVFKENYVT LLGTFDECYP TYLYQKIDES KLKAYTRYQL
760 770 780 790 800
RGYIEDSQDL EIYLIRYNAK HETVNVPGTG SLWPLSAQSP IGKCGEPNRC
810 820 830 840 850
APHLEWNPDL DCSCRDGEKC AHHSHHFSLD IDVGCTDLNE DLGVWVIFKI
860 870 880 890 900
KTQDGHARLG NLEFLEEKPL VGEALARVKR AEKKWRDKRE KLEWETNIVY
910 920 930 940 950
KEAKESVDAL FVNSQYDQLQ ADTNIAMIHA ADKRVHSIRE AYLPELSVIP
960 970 980 990 1000
GVNAAIFEEL EGRIFTAFSL YDARNVIKNG DFNNGLSCWN VKGHVDVEEQ
1010 1020 1030 1040 1050
NNQRSVLVVP EWEAEVSQEV RVCPGRGYIL RVTAYKEGYG EGCVTIHEIE
1060 1070 1080 1090 1100
NNTDELKFSN CVEEEIYPNN TVTCNDYTVN QEEYGGAYTS RNRGYNEAPS
1110 1120 1130 1140 1150
VPADYASVYE EKSYTDGRRE NPCEFNRGYR DYTPLPVGYV TKELEYFPET
1160 1170
DKVWIEIGET EGTFIVDSVE LLLMEE
Length:1,176
Mass (Da):133,120
Last modified:March 15, 2005 - v1
Checksum:iE2EE15AF12E5DD85
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1009V → L in AAA22353 (PubMed:2581950).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti77P → L in strain: BNS3. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11250 Genomic DNA Translation: AAA22353.1
Y09663 mRNA Translation: CAA70856.1
J01554 Genomic DNA No translation available.
PIRiA22617

Similar proteinsi

Entry informationi

Entry nameiCR1AA_BACTK
AccessioniPrimary (citable) accession number: P0A366
Secondary accession number(s): P02965
, P09664, P09665, P16478, Q9RED5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: March 15, 2005
Last modified: May 23, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health