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Protein

Tyrosine-protein phosphatase CpsB

Gene

cpsB

Organism
Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Dephosphorylates CpsD. Involved in the regulation of capsular polysaccharide biosynthesis (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Cofactori

Mn2+By similarity

Pathwayi

GO - Molecular functioni

  1. manganese ion binding Source: InterPro
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. capsule polysaccharide biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Capsule biogenesis/degradation, Exopolysaccharide synthesis

Keywords - Ligandi

Manganese

Enzyme and pathway databases

BioCyciSAGA208435:GHVY-1268-MONOMER.
UniPathwayiUPA00934.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase CpsB (EC:3.1.3.48)
Gene namesi
Name:cpsB
Synonyms:cpsIaB
Ordered Locus Names:SAG1174
OrganismiStreptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
Taxonomic identifieri208435 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000821 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 243243Tyrosine-protein phosphatase CpsBPRO_0000057890Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi208435.SAG1174.

Structurei

3D structure databases

ProteinModelPortaliP0A364.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CpsB/CapC family.Curated

Phylogenomic databases

HOGENOMiHOG000007624.
KOiK01104.
OMAiTPHTLNG.
OrthoDBiEOG6PKFDD.

Family and domain databases

InterProiIPR016667. Caps_polysacc_synth_CpsB/CapC.
IPR004013. PHP_C.
[Graphical view]
PfamiPF02811. PHP. 1 hit.
[Graphical view]
PIRSFiPIRSF016557. Caps_synth_CpsB. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A364-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDIHSHIVF DVDDGPKTLE ESLSLIEESY RQGVRIIVST SHRRKGMFET
60 70 80 90 100
PEDIIFKNFS IVKHEAEKRF EHLQILYGGE LYYTSDMLEK LKLKQIPTLN
110 120 130 140 150
NTKFALIEFS MQTSWKDIHT ALSNVLMLGI TPVVAHIERY NALENQKERV
160 170 180 190 200
KEIINMGCYT QINSSHILKQ KLFNDKHKRF KKRARYFLEE NLVHFVASDM
210 220 230 240
HNLDVRPPFL AEAYKIICRD FGKERANQLF IENAQSILKN HYI
Length:243
Mass (Da):28,600
Last modified:March 15, 2005 - v1
Checksum:i319CA48CCB310123
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF349539 Genomic DNA. Translation: AAK29648.1.
AE009948 Genomic DNA. Translation: AAN00056.1.
RefSeqiNP_688183.1. NC_004116.1.
WP_000565383.1. NC_004116.1.
YP_007968738.1. NC_021195.1.

Genome annotation databases

EnsemblBacteriaiAAN00056; AAN00056; SAG1174.
GeneIDi1013981.
15485505.
KEGGisag:SAG1174.
sagl:GBS222_1004.
PATRICi19629184. VBIStrAga72745_1180.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF349539 Genomic DNA. Translation: AAK29648.1.
AE009948 Genomic DNA. Translation: AAN00056.1.
RefSeqiNP_688183.1. NC_004116.1.
WP_000565383.1. NC_004116.1.
YP_007968738.1. NC_021195.1.

3D structure databases

ProteinModelPortaliP0A364.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208435.SAG1174.

Protocols and materials databases

DNASUi1013981.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN00056; AAN00056; SAG1174.
GeneIDi1013981.
15485505.
KEGGisag:SAG1174.
sagl:GBS222_1004.
PATRICi19629184. VBIStrAga72745_1180.

Phylogenomic databases

HOGENOMiHOG000007624.
KOiK01104.
OMAiTPHTLNG.
OrthoDBiEOG6PKFDD.

Enzyme and pathway databases

UniPathwayiUPA00934.
BioCyciSAGA208435:GHVY-1268-MONOMER.

Family and domain databases

InterProiIPR016667. Caps_polysacc_synth_CpsB/CapC.
IPR004013. PHP_C.
[Graphical view]
PfamiPF02811. PHP. 1 hit.
[Graphical view]
PIRSFiPIRSF016557. Caps_synth_CpsB. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Streptococcus agalactiae type V polysaccharide synthesis operon complete sequence."
    McKinnon K., Chaffin D.O., Rubens C.E.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: CNCTC 1/82 / Serotype V.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-611 / 2603 V/R.

Entry informationi

Entry nameiCPSB_STRA5
AccessioniPrimary (citable) accession number: P0A364
Secondary accession number(s): Q9S0S9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: January 7, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.