P0A364 (CPSB_STRA5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tyrosine-protein phosphatase CpsB
EC=3.1.3.48

Gene names

Name:	cpsB
Synonyms:	cpsIaB
Ordered Locus Names:	SAG1174

Organism

Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R) [Complete proteome] [HAMAP]

Taxonomic identifier

208435 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus agalactiae › Streptococcus agalactiae serogroup V

Protein attributes

Sequence length	243 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Dephosphorylates CpsD. Involved in the regulation of capsular polysaccharide biosynthesis By similarity.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Cofactor	Manganese By similarity.
Pathway	Capsule biogenesis; capsule polysaccharide biosynthesis.
Sequence similarities	Belongs to the CpsB/CapC family.

Ontologies

Keywords
Biological process	Capsule biogenesis/degradation Exopolysaccharide synthesis
Ligand	Manganese
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	capsule polysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Molecular_function	manganese ion binding Inferred from electronic annotation. Source: InterPro protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 243	243	Tyrosine-protein phosphatase CpsB		PRO_0000057890

Sequences

	Sequence		Length	Mass (Da)
	P0A364 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: 319CA48CCB310123	FASTA	243	28,600
	10 20 30 40 50 60 MIDIHSHIVF DVDDGPKTLE ESLSLIEESY RQGVRIIVST SHRRKGMFET PEDIIFKNFS 70 80 90 100 110 120 IVKHEAEKRF EHLQILYGGE LYYTSDMLEK LKLKQIPTLN NTKFALIEFS MQTSWKDIHT 130 140 150 160 170 180 ALSNVLMLGI TPVVAHIERY NALENQKERV KEIINMGCYT QINSSHILKQ KLFNDKHKRF 190 200 210 220 230 240 KKRARYFLEE NLVHFVASDM HNLDVRPPFL AEAYKIICRD FGKERANQLF IENAQSILKN HYI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Streptococcus agalactiae type V polysaccharide synthesis operon complete sequence." McKinnon K., Chaffin D.O., Rubens C.E. Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: CNCTC 1/82 / Serotype V.
[2]	"Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae." Tettelin H., Masignani V., Cieslewicz M.J., Eisen J.A., Peterson S.N., Wessels M.R., Paulsen I.T., Nelson K.E., Margarit I., Read T.D., Madoff L.C., Wolf A.M., Beanan M.J., Brinkac L.M., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F. , Madupu R., Lewis M.R., Radune D., Fedorova N.B., Scanlan D., Khouri H.M., Mulligan S., Carty H.A., Cline R.T., Van Aken S.E., Gill J., Scarselli M., Mora M., Iacobini E.T., Brettoni C., Galli G., Mariani M., Vegni F., Maione D., Rinaudo D., Rappuoli R., Telford J.L., Kasper D.L., Grandi G., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 99:12391-12396(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-611 / 2603 V/R.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF349539 Genomic DNA. Translation: AAK29648.1. AE009948 Genomic DNA. Translation: AAN00056.1.
RefSeq	NP_688183.1. NC_004116.1.
3D structure databases
ProteinModelPortal	P0A364.
ModBase	Search...
Protein-protein interaction databases
STRING	208435.SAG1174.
Protocols and materials databases
DNASU	1013981.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAN00056; AAN00056; SAG1174.
GeneID	1013981.
KEGG	sag:SAG1174.
PATRIC	19629184. VBIStrAga72745_1180.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000007624.
KO	K01104.
OMA	MIDVHSH.
ProtClustDB	CLSK883942.
Enzyme and pathway databases
BioCyc	SAGA208435:GHVY-1175-MONOMER.
UniPathway	UPA00934.
Family and domain databases
InterPro	IPR016667. Caps_polysacc_synth_CpsB/CapC. IPR004013. PHP_C. [Graphical view]
Pfam	PF02811. PHP. 1 hit. [Graphical view]
PIRSF	PIRSF016557. Caps_synth_CpsB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CPSB_STRA5

Accession

Primary (citable) accession number: P0A364
Secondary accession number(s): Q9S0S9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	March 15, 2005
Last modified:	May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program