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Protein

Arginase

Gene

arcB

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-arginine + H2O = L-ornithine + urea.

Cofactori

Mn2+PROSITE-ProRule annotationNote: Binds 2 manganese ions per subunit.PROSITE-ProRule annotation

Pathway: urea cycle

This protein is involved in step 1 of the subpathway that synthesizes L-ornithine and urea from L-arginine.
Proteins known to be involved in this subpathway in this organism are:
  1. Arginase (arcB)
This subpathway is part of the pathway urea cycle, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-ornithine and urea from L-arginine, the pathway urea cycle and in Nitrogen metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi96 – 961Manganese 1PROSITE-ProRule annotation
Metal bindingi123 – 1231Manganese 1PROSITE-ProRule annotation
Metal bindingi123 – 1231Manganese 2PROSITE-ProRule annotation
Metal bindingi125 – 1251Manganese 2PROSITE-ProRule annotation
Metal bindingi127 – 1271Manganese 1PROSITE-ProRule annotation
Binding sitei178 – 1781SubstrateBy similarity
Metal bindingi226 – 2261Manganese 1PROSITE-ProRule annotation
Metal bindingi226 – 2261Manganese 2PROSITE-ProRule annotation
Metal bindingi228 – 2281Manganese 2PROSITE-ProRule annotation
Binding sitei271 – 2711SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Arginine metabolism

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciBABO262698:GJC2-2542-MONOMER.
UniPathwayiUPA00158; UER00270.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginase (EC:3.5.3.1)
Gene namesi
Name:arcB
Synonyms:rocF
Ordered Locus Names:BruAb2_0333
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000540 Componenti: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306ArginasePRO_0000173716Add
BLAST

Proteomic databases

PRIDEiP0A2Y1.

Structurei

3D structure databases

ProteinModelPortaliP0A2Y1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni125 – 1295Substrate bindingBy similarity
Regioni136 – 1383Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the arginase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0010.
HOGENOMiHOG000204319.
KOiK01476.
OMAiITVHDMR.
OrthoDBiEOG6BKJ5H.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR014033. Arginase.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
PRINTSiPR00116. ARGINASE.
TIGRFAMsiTIGR01229. rocF_arginase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A2Y1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHCKILGLPV QEGTGRKGCN MGPDSYRAAG IADAIRELGH ECTDLGNLAP
60 70 80 90 100
AAQRPLQHPN HAIKALPYAV AWIEAISEAA YRESAEGFPI FLGGDHLLAA
110 120 130 140 150
GTVPGIARRA AEKGRKQFVL WLDAHTDFHT LETTTSGNLH GTPVAYYTGQ
160 170 180 190 200
KGFEGYFPKL AAPIDPHNVC MLGIRSVDPA EREAVKKTEV IVYDMRLIDE
210 220 230 240 250
HGVAALLRRF LERVKAEDGL LHVSLDVDFL DPSIAPAVGT TVPGGATFRE
260 270 280 290 300
AHLIMEMLHD SGLVTSLDLV ELNPFLDERG RTAAVMVDLM ASLLGRSVMD

RPTISY
Length:306
Mass (Da):33,182
Last modified:March 15, 2005 - v1
Checksum:iA953867BC04570B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57319 Genomic DNA. Translation: AAC05588.1.
AE017224 Genomic DNA. Translation: AAX75764.1.
RefSeqiWP_002965747.1. NC_006933.1.
YP_223125.1. NC_006933.1.

Genome annotation databases

EnsemblBacteriaiAAX75764; AAX75764; BruAb2_0333.
GeneIDi3827836.
KEGGibmb:BruAb2_0333.
PATRICi17826904. VBIBruAbo15061_2635.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57319 Genomic DNA. Translation: AAC05588.1.
AE017224 Genomic DNA. Translation: AAX75764.1.
RefSeqiWP_002965747.1. NC_006933.1.
YP_223125.1. NC_006933.1.

3D structure databases

ProteinModelPortaliP0A2Y1.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP0A2Y1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAX75764; AAX75764; BruAb2_0333.
GeneIDi3827836.
KEGGibmb:BruAb2_0333.
PATRICi17826904. VBIBruAbo15061_2635.

Phylogenomic databases

eggNOGiCOG0010.
HOGENOMiHOG000204319.
KOiK01476.
OMAiITVHDMR.
OrthoDBiEOG6BKJ5H.

Enzyme and pathway databases

UniPathwayiUPA00158; UER00270.
BioCyciBABO262698:GJC2-2542-MONOMER.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR014033. Arginase.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
PRINTSiPR00116. ARGINASE.
TIGRFAMsiTIGR01229. rocF_arginase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Brucella abortus arginase and ornithine cyclodeaminase genes are similar to Ti plasmid arginase and ornithine cyclodeaminase."
    Kim J., Mayfield J.E.
    Biochim. Biophys. Acta 1354:55-57(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 19.
  2. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.

Entry informationi

Entry nameiARGI_BRUAB
AccessioniPrimary (citable) accession number: P0A2Y1
Secondary accession number(s): Q579C0, Q59174
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: June 24, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.