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P0A2Y1

- ARGI_BRUAB

UniProt

P0A2Y1 - ARGI_BRUAB

Protein

Arginase

Gene

arcB

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-arginine + H2O = L-ornithine + urea.

    Cofactori

    Binds 2 manganese ions per subunit.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi96 – 961Manganese 1PROSITE-ProRule annotation
    Metal bindingi123 – 1231Manganese 1PROSITE-ProRule annotation
    Metal bindingi123 – 1231Manganese 2PROSITE-ProRule annotation
    Metal bindingi125 – 1251Manganese 2PROSITE-ProRule annotation
    Metal bindingi127 – 1271Manganese 1PROSITE-ProRule annotation
    Binding sitei178 – 1781SubstrateBy similarity
    Metal bindingi226 – 2261Manganese 1PROSITE-ProRule annotation
    Metal bindingi226 – 2261Manganese 2PROSITE-ProRule annotation
    Metal bindingi228 – 2281Manganese 2PROSITE-ProRule annotation
    Binding sitei271 – 2711SubstrateBy similarity

    GO - Molecular functioni

    1. arginase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. arginine metabolic process Source: UniProtKB-KW
    2. urea cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Arginine metabolism

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciBABO262698:GJC2-2542-MONOMER.
    UniPathwayiUPA00158; UER00270.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arginase (EC:3.5.3.1)
    Gene namesi
    Name:arcB
    Synonyms:rocF
    Ordered Locus Names:BruAb2_0333
    OrganismiBrucella abortus biovar 1 (strain 9-941)
    Taxonomic identifieri262698 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000540: Chromosome II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 306306ArginasePRO_0000173716Add
    BLAST

    Proteomic databases

    PRIDEiP0A2Y1.

    Interactioni

    Protein-protein interaction databases

    STRINGi262698.BruAb2_0333.

    Structurei

    3D structure databases

    ProteinModelPortaliP0A2Y1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni125 – 1295Substrate bindingBy similarity
    Regioni136 – 1383Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the arginase family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0010.
    HOGENOMiHOG000204319.
    KOiK01476.
    OMAiVMELNPA.
    OrthoDBiEOG6BKJ5H.

    Family and domain databases

    Gene3Di3.40.800.10. 1 hit.
    InterProiIPR014033. Arginase.
    IPR006035. Ureohydrolase.
    IPR023696. Ureohydrolase_domain.
    IPR020855. Ureohydrolase_Mn_BS.
    [Graphical view]
    PANTHERiPTHR11358. PTHR11358. 1 hit.
    PfamiPF00491. Arginase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036979. Arginase. 1 hit.
    PRINTSiPR00116. ARGINASE.
    TIGRFAMsiTIGR01229. rocF_arginase. 1 hit.
    PROSITEiPS01053. ARGINASE_1. 1 hit.
    PS51409. ARGINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0A2Y1-1 [UniParc]FASTAAdd to Basket

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    MHCKILGLPV QEGTGRKGCN MGPDSYRAAG IADAIRELGH ECTDLGNLAP    50
    AAQRPLQHPN HAIKALPYAV AWIEAISEAA YRESAEGFPI FLGGDHLLAA 100
    GTVPGIARRA AEKGRKQFVL WLDAHTDFHT LETTTSGNLH GTPVAYYTGQ 150
    KGFEGYFPKL AAPIDPHNVC MLGIRSVDPA EREAVKKTEV IVYDMRLIDE 200
    HGVAALLRRF LERVKAEDGL LHVSLDVDFL DPSIAPAVGT TVPGGATFRE 250
    AHLIMEMLHD SGLVTSLDLV ELNPFLDERG RTAAVMVDLM ASLLGRSVMD 300
    RPTISY 306
    Length:306
    Mass (Da):33,182
    Last modified:March 15, 2005 - v1
    Checksum:iA953867BC04570B3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U57319 Genomic DNA. Translation: AAC05588.1.
    AE017224 Genomic DNA. Translation: AAX75764.1.
    RefSeqiYP_223125.1. NC_006933.1.

    Genome annotation databases

    EnsemblBacteriaiAAX75764; AAX75764; BruAb2_0333.
    GeneIDi3341875.
    KEGGibmb:BruAb2_0333.
    PATRICi17826904. VBIBruAbo15061_2635.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U57319 Genomic DNA. Translation: AAC05588.1 .
    AE017224 Genomic DNA. Translation: AAX75764.1 .
    RefSeqi YP_223125.1. NC_006933.1.

    3D structure databases

    ProteinModelPortali P0A2Y1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262698.BruAb2_0333.

    Proteomic databases

    PRIDEi P0A2Y1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX75764 ; AAX75764 ; BruAb2_0333 .
    GeneIDi 3341875.
    KEGGi bmb:BruAb2_0333.
    PATRICi 17826904. VBIBruAbo15061_2635.

    Phylogenomic databases

    eggNOGi COG0010.
    HOGENOMi HOG000204319.
    KOi K01476.
    OMAi VMELNPA.
    OrthoDBi EOG6BKJ5H.

    Enzyme and pathway databases

    UniPathwayi UPA00158 ; UER00270 .
    BioCyci BABO262698:GJC2-2542-MONOMER.

    Family and domain databases

    Gene3Di 3.40.800.10. 1 hit.
    InterProi IPR014033. Arginase.
    IPR006035. Ureohydrolase.
    IPR023696. Ureohydrolase_domain.
    IPR020855. Ureohydrolase_Mn_BS.
    [Graphical view ]
    PANTHERi PTHR11358. PTHR11358. 1 hit.
    Pfami PF00491. Arginase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036979. Arginase. 1 hit.
    PRINTSi PR00116. ARGINASE.
    TIGRFAMsi TIGR01229. rocF_arginase. 1 hit.
    PROSITEi PS01053. ARGINASE_1. 1 hit.
    PS51409. ARGINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Brucella abortus arginase and ornithine cyclodeaminase genes are similar to Ti plasmid arginase and ornithine cyclodeaminase."
      Kim J., Mayfield J.E.
      Biochim. Biophys. Acta 1354:55-57(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 19.
    2. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
      Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
      J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 9-941.

    Entry informationi

    Entry nameiARGI_BRUAB
    AccessioniPrimary (citable) accession number: P0A2Y1
    Secondary accession number(s): Q579C0, Q59174
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella abortus strain 9-941
      Brucella abortus (strain 9-941): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3