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P0A2Y1

- ARGI_BRUAB

UniProt

P0A2Y1 - ARGI_BRUAB

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Protein

Arginase

Gene
arcB, rocF, BruAb2_0333
Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

L-arginine + H2O = L-ornithine + urea.

Cofactori

Binds 2 manganese ions per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi96 – 961Manganese 1 By similarity
Metal bindingi123 – 1231Manganese 1 By similarity
Metal bindingi123 – 1231Manganese 2 By similarity
Metal bindingi125 – 1251Manganese 2 By similarity
Metal bindingi127 – 1271Manganese 1 By similarity
Binding sitei178 – 1781Substrate By similarity
Metal bindingi226 – 2261Manganese 1 By similarity
Metal bindingi226 – 2261Manganese 2 By similarity
Metal bindingi228 – 2281Manganese 2 By similarity
Binding sitei271 – 2711Substrate By similarity

GO - Molecular functioni

  1. arginase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. arginine metabolic process Source: UniProtKB-KW
  2. urea cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Arginine metabolism

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciBABO262698:GJC2-2542-MONOMER.
UniPathwayiUPA00158; UER00270.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginase (EC:3.5.3.1)
Gene namesi
Name:arcB
Synonyms:rocF
Ordered Locus Names:BruAb2_0333
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000540: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306ArginasePRO_0000173716Add
BLAST

Proteomic databases

PRIDEiP0A2Y1.

Interactioni

Protein-protein interaction databases

STRINGi262698.BruAb2_0333.

Structurei

3D structure databases

ProteinModelPortaliP0A2Y1.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni125 – 1295Substrate binding By similarity
Regioni136 – 1383Substrate binding By similarity

Sequence similaritiesi

Belongs to the arginase family.

Phylogenomic databases

eggNOGiCOG0010.
HOGENOMiHOG000204319.
KOiK01476.
OMAiVMELNPA.
OrthoDBiEOG6BKJ5H.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR014033. Arginase.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
PRINTSiPR00116. ARGINASE.
TIGRFAMsiTIGR01229. rocF_arginase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A2Y1-1 [UniParc]FASTAAdd to Basket

« Hide

MHCKILGLPV QEGTGRKGCN MGPDSYRAAG IADAIRELGH ECTDLGNLAP    50
AAQRPLQHPN HAIKALPYAV AWIEAISEAA YRESAEGFPI FLGGDHLLAA 100
GTVPGIARRA AEKGRKQFVL WLDAHTDFHT LETTTSGNLH GTPVAYYTGQ 150
KGFEGYFPKL AAPIDPHNVC MLGIRSVDPA EREAVKKTEV IVYDMRLIDE 200
HGVAALLRRF LERVKAEDGL LHVSLDVDFL DPSIAPAVGT TVPGGATFRE 250
AHLIMEMLHD SGLVTSLDLV ELNPFLDERG RTAAVMVDLM ASLLGRSVMD 300
RPTISY 306
Length:306
Mass (Da):33,182
Last modified:March 15, 2005 - v1
Checksum:iA953867BC04570B3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U57319 Genomic DNA. Translation: AAC05588.1.
AE017224 Genomic DNA. Translation: AAX75764.1.
RefSeqiYP_223125.1. NC_006933.1.

Genome annotation databases

EnsemblBacteriaiAAX75764; AAX75764; BruAb2_0333.
GeneIDi3341875.
KEGGibmb:BruAb2_0333.
PATRICi17826904. VBIBruAbo15061_2635.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U57319 Genomic DNA. Translation: AAC05588.1 .
AE017224 Genomic DNA. Translation: AAX75764.1 .
RefSeqi YP_223125.1. NC_006933.1.

3D structure databases

ProteinModelPortali P0A2Y1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262698.BruAb2_0333.

Proteomic databases

PRIDEi P0A2Y1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAX75764 ; AAX75764 ; BruAb2_0333 .
GeneIDi 3341875.
KEGGi bmb:BruAb2_0333.
PATRICi 17826904. VBIBruAbo15061_2635.

Phylogenomic databases

eggNOGi COG0010.
HOGENOMi HOG000204319.
KOi K01476.
OMAi VMELNPA.
OrthoDBi EOG6BKJ5H.

Enzyme and pathway databases

UniPathwayi UPA00158 ; UER00270 .
BioCyci BABO262698:GJC2-2542-MONOMER.

Family and domain databases

Gene3Di 3.40.800.10. 1 hit.
InterProi IPR014033. Arginase.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view ]
PANTHERi PTHR11358. PTHR11358. 1 hit.
Pfami PF00491. Arginase. 1 hit.
[Graphical view ]
PIRSFi PIRSF036979. Arginase. 1 hit.
PRINTSi PR00116. ARGINASE.
TIGRFAMsi TIGR01229. rocF_arginase. 1 hit.
PROSITEi PS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Brucella abortus arginase and ornithine cyclodeaminase genes are similar to Ti plasmid arginase and ornithine cyclodeaminase."
    Kim J., Mayfield J.E.
    Biochim. Biophys. Acta 1354:55-57(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 19.
  2. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
    Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
    J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 9-941.

Entry informationi

Entry nameiARGI_BRUAB
AccessioniPrimary (citable) accession number: P0A2Y1
Secondary accession number(s): Q579C0, Q59174
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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