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Protein

Arginase

Gene

arcB

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-arginine + H2O = L-ornithine + urea.By similarity

Cofactori

Mn2+PROSITE-ProRule annotationNote: Binds 2 manganese ions per subunit.PROSITE-ProRule annotation

Pathwayi: urea cycle

This protein is involved in step 1 of the subpathway that synthesizes L-ornithine and urea from L-arginine.By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Arginase (arcB)
This subpathway is part of the pathway urea cycle, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-ornithine and urea from L-arginine, the pathway urea cycle and in Nitrogen metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi96Manganese 1PROSITE-ProRule annotation1
Metal bindingi123Manganese 1PROSITE-ProRule annotation1
Metal bindingi123Manganese 2PROSITE-ProRule annotation1
Metal bindingi125Manganese 2PROSITE-ProRule annotation1
Metal bindingi127Manganese 1PROSITE-ProRule annotation1
Binding sitei178SubstrateBy similarity1
Metal bindingi226Manganese 1PROSITE-ProRule annotation1
Metal bindingi226Manganese 2PROSITE-ProRule annotation1
Metal bindingi228Manganese 2PROSITE-ProRule annotation1
Binding sitei240SubstrateBy similarity1
Binding sitei271SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Arginine metabolism

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00158; UER00270.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginase (EC:3.5.3.1By similarity)
Gene namesi
Name:arcB
Synonyms:rocF
Ordered Locus Names:BruAb2_0333
OrganismiBrucella abortus biovar 1 (strain 9-941)
Taxonomic identifieri262698 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000540 Componenti: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001737161 – 306ArginaseAdd BLAST306

Structurei

3D structure databases

ProteinModelPortaliP0A2Y1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni125 – 129Substrate bindingBy similarity5
Regioni136 – 138Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the arginase family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000204319.
KOiK01476.
OMAiITVHDMR.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR014033. Arginase.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
PRINTSiPR00116. ARGINASE.
TIGRFAMsiTIGR01229. rocF_arginase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A2Y1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHCKILGLPV QEGTGRKGCN MGPDSYRAAG IADAIRELGH ECTDLGNLAP
60 70 80 90 100
AAQRPLQHPN HAIKALPYAV AWIEAISEAA YRESAEGFPI FLGGDHLLAA
110 120 130 140 150
GTVPGIARRA AEKGRKQFVL WLDAHTDFHT LETTTSGNLH GTPVAYYTGQ
160 170 180 190 200
KGFEGYFPKL AAPIDPHNVC MLGIRSVDPA EREAVKKTEV IVYDMRLIDE
210 220 230 240 250
HGVAALLRRF LERVKAEDGL LHVSLDVDFL DPSIAPAVGT TVPGGATFRE
260 270 280 290 300
AHLIMEMLHD SGLVTSLDLV ELNPFLDERG RTAAVMVDLM ASLLGRSVMD

RPTISY
Length:306
Mass (Da):33,182
Last modified:March 15, 2005 - v1
Checksum:iA953867BC04570B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57319 Genomic DNA. Translation: AAC05588.1.
AE017224 Genomic DNA. Translation: AAX75764.1.
RefSeqiWP_002965747.1. NC_006933.1.

Genome annotation databases

EnsemblBacteriaiAAX75764; AAX75764; BruAb2_0333.
GeneIDi3827836.
KEGGibmb:BruAb2_0333.
PATRICi17826904. VBIBruAbo15061_2635.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57319 Genomic DNA. Translation: AAC05588.1.
AE017224 Genomic DNA. Translation: AAX75764.1.
RefSeqiWP_002965747.1. NC_006933.1.

3D structure databases

ProteinModelPortaliP0A2Y1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAX75764; AAX75764; BruAb2_0333.
GeneIDi3827836.
KEGGibmb:BruAb2_0333.
PATRICi17826904. VBIBruAbo15061_2635.

Phylogenomic databases

HOGENOMiHOG000204319.
KOiK01476.
OMAiITVHDMR.

Enzyme and pathway databases

UniPathwayiUPA00158; UER00270.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR014033. Arginase.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
PRINTSiPR00116. ARGINASE.
TIGRFAMsiTIGR01229. rocF_arginase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARGI_BRUAB
AccessioniPrimary (citable) accession number: P0A2Y1
Secondary accession number(s): Q579C0, Q59174
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: November 2, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 9-941
    Brucella abortus (strain 9-941): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.