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Protein

Carbamate kinase 1

Gene

arcC1

Organism
Enterococcus faecalis (strain ATCC 700802 / V583)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP. Can also catalyze, although with low efficiency, the phosphorylation of bicarbonate, leading to the formation of carboxyphosphate, an unstable intermediate found in the reactions catalyzed by carbamoyl-phosphate synthase and biotin carboxylase. Can also use acetate.

Catalytic activityi

ATP + NH3 + CO2 = ADP + carbamoyl phosphate.

Enzyme regulationi

Inhibited by adenosine(5')pentaphospho(5')adenosine (Ap5A), Ap6A and to a much lower extent by Ap4A.

Pathwayi: carbamoyl phosphate degradation

This protein is involved in step 1 of the subpathway that synthesizes CO(2) and NH(3) from carbamoyl phosphate.
Proteins known to be involved in this subpathway in this organism are:
  1. Carbamate kinase 1 (arcC1), Carbamate kinase 2 (arcC2)
This subpathway is part of the pathway carbamoyl phosphate degradation, which is itself part of Metabolic intermediate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CO(2) and NH(3) from carbamoyl phosphate, the pathway carbamoyl phosphate degradation and in Metabolic intermediate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Arginine metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.2.2. 2096.
SABIO-RKP0A2X7.
UniPathwayiUPA00996; UER00366.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbamate kinase 1 (EC:2.7.2.2)
Gene namesi
Name:arcC1
Synonyms:arcC, arcC-1
Ordered Locus Names:EF_0106
OrganismiEnterococcus faecalis (strain ATCC 700802 / V583)
Taxonomic identifieri226185 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
Proteomesi
  • UP000001415 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001851222 – 310Carbamate kinase 1Add BLAST309

Expressioni

Inductioni

By arginine.

Interactioni

Subunit structurei

Homodimer (predominantly) and homotetramer.

Protein-protein interaction databases

STRINGi226185.EF0106.

Structurei

Secondary structure

1310
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 8Combined sources5
Helixi11 – 14Combined sources4
Beta strandi15 – 17Combined sources3
Helixi21 – 40Combined sources20
Beta strandi44 – 48Combined sources5
Helixi52 – 64Combined sources13
Beta strandi67 – 70Combined sources4
Helixi75 – 100Combined sources26
Beta strandi107 – 110Combined sources4
Beta strandi113 – 116Combined sources4
Helixi121 – 124Combined sources4
Beta strandi128 – 134Combined sources7
Helixi136 – 143Combined sources8
Turni144 – 146Combined sources3
Beta strandi149 – 151Combined sources3
Turni153 – 155Combined sources3
Beta strandi157 – 161Combined sources5
Beta strandi166 – 169Combined sources4
Helixi172 – 180Combined sources9
Beta strandi184 – 186Combined sources3
Helixi189 – 191Combined sources3
Beta strandi193 – 196Combined sources4
Turni197 – 200Combined sources4
Helixi209 – 219Combined sources11
Beta strandi223 – 228Combined sources6
Beta strandi235 – 237Combined sources3
Beta strandi244 – 246Combined sources3
Beta strandi248 – 250Combined sources3
Helixi251 – 259Combined sources9
Turni265 – 268Combined sources4
Helixi269 – 281Combined sources13
Beta strandi286 – 290Combined sources5
Helixi293 – 297Combined sources5
Beta strandi305 – 309Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WE4X-ray2.02A/B/C/D1-310[»]
2WE5X-ray1.39A/B/C1-310[»]
ProteinModelPortaliP0A2X7.
SMRiP0A2X7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A2X7.

Family & Domainsi

Sequence similaritiesi

Belongs to the carbamate kinase family.Curated

Phylogenomic databases

eggNOGiENOG4105C5B. Bacteria.
COG0549. LUCA.
KOiK00926.
OMAiADIFMIL.

Family and domain databases

CDDicd04235. AAK_CK. 1 hit.
Gene3Di3.40.1160.10. 1 hit.
InterProiIPR001048. Asp/Glu/Uridylate_kinase.
IPR003964. Carb_kinase.
[Graphical view]
PANTHERiPTHR30409. PTHR30409. 1 hit.
PfamiPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000723. Carbamate_kin. 1 hit.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR00746. arcC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A2X7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKKMVVALG GNAILSNDAS AHAQQQALVQ TSAYLVHLIK QGHRLIVSHG
60 70 80 90 100
NGPQVGNLLL QQQAADSEKN PAMPLDTCVA MTQGSIGYWL SNALNQELNK
110 120 130 140 150
AGIKKQVATV LTQVVVDPAD EAFKNPTKPI GPFLTEAEAK EAMQAGAIFK
160 170 180 190 200
EDAGRGWRKV VPSPKPIDIH EAETINTLIK NDIITISCGG GGIPVVGQEL
210 220 230 240 250
KGVEAVIDKD FASEKLAELV DADALVILTG VDYVCINYGK PDEKQLTNVT
260 270 280 290 300
VAELEEYKQA GHFAPGSMLP KIEAAIQFVE SQPNKQAIIT SLENLGSMSG
310
DEIVGTVVTK
Length:310
Mass (Da):32,927
Last modified:January 23, 2007 - v2
Checksum:iE214B3BA542A89D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223332 Genomic DNA. Translation: CAA11271.1.
AJ312276 Genomic DNA. Translation: CAC41343.1.
AE016830 Genomic DNA. Translation: AAO79981.1.
RefSeqiNP_813909.1. NC_004668.1.
WP_002356132.1. NZ_KE136524.1.

Genome annotation databases

EnsemblBacteriaiAAO79981; AAO79981; EF_0106.
GeneIDi1199007.
KEGGiefa:EF0106.
PATRICi21850629. VBIEntFae7065_0096.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ223332 Genomic DNA. Translation: CAA11271.1.
AJ312276 Genomic DNA. Translation: CAC41343.1.
AE016830 Genomic DNA. Translation: AAO79981.1.
RefSeqiNP_813909.1. NC_004668.1.
WP_002356132.1. NZ_KE136524.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WE4X-ray2.02A/B/C/D1-310[»]
2WE5X-ray1.39A/B/C1-310[»]
ProteinModelPortaliP0A2X7.
SMRiP0A2X7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi226185.EF0106.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO79981; AAO79981; EF_0106.
GeneIDi1199007.
KEGGiefa:EF0106.
PATRICi21850629. VBIEntFae7065_0096.

Phylogenomic databases

eggNOGiENOG4105C5B. Bacteria.
COG0549. LUCA.
KOiK00926.
OMAiADIFMIL.

Enzyme and pathway databases

UniPathwayiUPA00996; UER00366.
BRENDAi2.7.2.2. 2096.
SABIO-RKP0A2X7.

Miscellaneous databases

EvolutionaryTraceiP0A2X7.

Family and domain databases

CDDicd04235. AAK_CK. 1 hit.
Gene3Di3.40.1160.10. 1 hit.
InterProiIPR001048. Asp/Glu/Uridylate_kinase.
IPR003964. Carb_kinase.
[Graphical view]
PANTHERiPTHR30409. PTHR30409. 1 hit.
PfamiPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000723. Carbamate_kin. 1 hit.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR00746. arcC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARCC1_ENTFA
AccessioniPrimary (citable) accession number: P0A2X7
Secondary accession number(s): O54531, P35836
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.