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P0A2X3

- EXOA_STRPN

UniProt

P0A2X3 - EXOA_STRPN

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Protein

Exodeoxyribonuclease

Gene
exoA, SP_1845
Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

In addition to 3'- to 5'-exonuclease and 3'-phosphatase activities, ExoA was shown to make single-strand breaks at apurinic sites in DNA By similarity.

Catalytic activityi

Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.

Cofactori

Magnesium. Can also utilize manganese. Probably binds two magnesium or manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi9 – 91Magnesium 1 By similarity
Metal bindingi44 – 441Magnesium 1 By similarity
Active sitei128 – 1281 By similarity
Active sitei167 – 1671Proton donor/acceptor By similarity
Metal bindingi167 – 1671Magnesium 2 By similarity
Metal bindingi169 – 1691Magnesium 2 By similarity
Sitei169 – 1691Transition state stabilizer By similarity
Sitei240 – 2401Important for catalytic activity By similarity
Metal bindingi265 – 2651Magnesium 1 By similarity
Sitei266 – 2661Interaction with DNA substrate By similarity

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. endonuclease activity Source: InterPro
  3. exodeoxyribonuclease III activity Source: UniProtKB-EC
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA repair Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciSPNE170187:GHGN-1853-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Exodeoxyribonuclease (EC:3.1.11.2)
Gene namesi
Name:exoA
Ordered Locus Names:SP_1845
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000585: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 275275ExodeoxyribonucleasePRO_0000200026Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi170187.SP_1845.

Structurei

3D structure databases

ProteinModelPortaliP0A2X3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0708.
HOGENOMiHOG000034586.
KOiK01142.
OMAiGWRIDYY.
OrthoDBiEOG6TBHJS.

Family and domain databases

Gene3Di3.60.10.10. 1 hit.
InterProiIPR004808. AP_endonuc_1.
IPR020847. AP_endonuclease_F1_BS.
IPR020848. AP_endonuclease_F1_CS.
IPR005135. Endo/exonuclease/phosphatase.
[Graphical view]
PANTHERiPTHR22748. PTHR22748. 1 hit.
PfamiPF03372. Exo_endo_phos. 1 hit.
[Graphical view]
SUPFAMiSSF56219. SSF56219. 1 hit.
TIGRFAMsiTIGR00633. xth. 1 hit.
PROSITEiPS00726. AP_NUCLEASE_F1_1. 1 hit.
PS00727. AP_NUCLEASE_F1_2. 1 hit.
PS00728. AP_NUCLEASE_F1_3. 1 hit.
PS51435. AP_NUCLEASE_F1_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A2X3-1 [UniParc]FASTAAdd to Basket

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MKLISWNIDS LNAALTSDSA RAKLSQEVLQ TLVAENADII AIQETKLSAK    50
GPTKKHVEIL EELFPGYENT WRSSQEPARK GYAGTMFLYK KELTPTISFP 100
EIGAPSTMDL EGRIITLEFD AFFVTQVYTP NAGDGLKRLE ERQVWDAKYA 150
EYLAELDKEK PVLATGDYNV AHNEIDLANP ASNRRSPGFT DEERAGFTNL 200
LATGFTDTFR HVHGDVPERY TWWAQRSKTS KINNTGWRID YWLTSNRIAD 250
KVTKSDMIDS GARQDHTPIV LEIDL 275
Length:275
Mass (Da):31,064
Last modified:March 15, 2005 - v1
Checksum:i112E5A9FF828A1B9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005672 Genomic DNA. Translation: AAK75918.1.
PIRiE95215.
RefSeqiNP_346278.1. NC_003028.3.

Genome annotation databases

EnsemblBacteriaiAAK75918; AAK75918; SP_1845.
GeneIDi930987.
KEGGispn:SP_1845.
PATRICi19708143. VBIStrPne105772_1914.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005672 Genomic DNA. Translation: AAK75918.1 .
PIRi E95215.
RefSeqi NP_346278.1. NC_003028.3.

3D structure databases

ProteinModelPortali P0A2X3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 170187.SP_1845.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK75918 ; AAK75918 ; SP_1845 .
GeneIDi 930987.
KEGGi spn:SP_1845.
PATRICi 19708143. VBIStrPne105772_1914.

Phylogenomic databases

eggNOGi COG0708.
HOGENOMi HOG000034586.
KOi K01142.
OMAi GWRIDYY.
OrthoDBi EOG6TBHJS.

Enzyme and pathway databases

BioCyci SPNE170187:GHGN-1853-MONOMER.

Family and domain databases

Gene3Di 3.60.10.10. 1 hit.
InterProi IPR004808. AP_endonuc_1.
IPR020847. AP_endonuclease_F1_BS.
IPR020848. AP_endonuclease_F1_CS.
IPR005135. Endo/exonuclease/phosphatase.
[Graphical view ]
PANTHERi PTHR22748. PTHR22748. 1 hit.
Pfami PF03372. Exo_endo_phos. 1 hit.
[Graphical view ]
SUPFAMi SSF56219. SSF56219. 1 hit.
TIGRFAMsi TIGR00633. xth. 1 hit.
PROSITEi PS00726. AP_NUCLEASE_F1_1. 1 hit.
PS00727. AP_NUCLEASE_F1_2. 1 hit.
PS00728. AP_NUCLEASE_F1_3. 1 hit.
PS51435. AP_NUCLEASE_F1_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-334 / TIGR4.

Entry informationi

Entry nameiEXOA_STRPN
AccessioniPrimary (citable) accession number: P0A2X3
Secondary accession number(s): P21998
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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