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P0A2W6 (ACPS_STRPN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Holo-[acyl-carrier-protein] synthase
Short name=Holo-ACP synthase
EC=2.7.8.7
Alternative name(s):
4'-phosphopantetheinyl transferase AcpS
Gene names
Name:acpS
Ordered Locus Names:SP_1699
OrganismStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) [Complete proteome] [HAMAP]
Taxonomic identifier170187 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus ›

Protein attributes

Sequence length120 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein By similarity. HAMAP-Rule MF_00101

Catalytic activity

CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein]. HAMAP-Rule MF_00101

Cofactor

Magnesium By similarity.

Subunit structure

Homotrimer. Ref.2

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the P-Pant transferase superfamily. AcpS family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 120120Holo-[acyl-carrier-protein] synthase HAMAP-Rule MF_00101
PRO_0000175713

Sites

Metal binding81Magnesium By similarity
Metal binding581Magnesium By similarity

Secondary structure

1 ...................... 120
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P0A2W6 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: 7FFB1848AC63DAEE

FASTA12013,388
        10         20         30         40         50         60 
MIVGHGIDIE ELASIESAVT RHEGFAKRVL TAQEMERFTS LKGRRQIEYL AGRWSAKEAF 

        70         80         90        100        110        120 
SKAMGTGISK LGFQDLEVLN NERGAPYFSQ APFSGKIWLS ISHTDQFVTA SVILEENHES

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of a virulent isolate of Streptococcus pneumoniae."
Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D., Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J., Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D., Umayam L.A., White O., Salzberg S.L. expand/collapse author list , Lewis M.R., Radune D., Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L., McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K., Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A., Morrison D.A., Hollingshead S.K., Fraser C.M.
Science 293:498-506(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-334 / TIGR4.
[2]"Crystal structure of Streptococcus pneumoniae acyl carrier protein synthase: an essential enzyme in bacterial fatty acid biosynthesis."
Chirgadze N.Y., Briggs S.L., McAllister K.A., Fischl A.S., Zhao G.
EMBO J. 19:5281-5287(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF COMPLEX WITH 3'-5'-ADP, SUBUNIT.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE005672 Genomic DNA. Translation: AAK75777.1.
PIRH95197.
RefSeqNP_346137.1. NC_003028.3.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1FTEX-ray2.40A/B/C1-120[»]
1FTFX-ray2.05A/B/C1-120[»]
1FTHX-ray1.90A/B/C1-120[»]
ProteinModelPortalP0A2W6.
SMRP0A2W6. Positions 1-117.
ModBaseSearch...

Protein-protein interaction databases

IntActP0A2W6. 5 interactions.
STRING170187.SP_1699.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK75777; AAK75777; SP_1699.
GeneID931136.
KEGGspn:SP_1699.
PATRIC19707841. VBIStrPne105772_1763.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0736.
HOGENOMHOG000014315.
KOK00997.
OMAVHVSITH.
ProtClustDBPRK00070.

Family and domain databases

Gene3D3.90.470.20. 1 hit.
HAMAPMF_00101. AcpS.
InterProIPR008278. 4-PPantetheinyl_Trfase_SF.
IPR002582. ACPS.
IPR004568. PPantethiene-prot_Trfase_dom.
[Graphical view]
PfamPF01648. ACPS. 1 hit.
[Graphical view]
ProDomPD004282. PPantethiene-prot_Trfase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF56214. 4-PPT_transf. 1 hit.
TIGRFAMsTIGR00516. acpS. 1 hit.
TIGR00556. pantethn_trn. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP0A2W6.

Entry information

Entry nameACPS_STRPN
AccessionPrimary (citable) accession number: P0A2W6
Secondary accession number(s): Q9F7T5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: May 1, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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