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P0A2W6 (ACPS_STRPN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Holo-[acyl-carrier-protein] synthase
Short name=Holo-ACP synthase
EC=2.7.8.7
Alternative name(s):
4'-phosphopantetheinyl transferase AcpS
Gene names
Name:acpS
Ordered Locus Names:SP_1699
OrganismStreptococcus pneumoniae [Complete proteome] [HAMAP]
Taxonomic identifier1313 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length120 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein By similarity. HAMAP MF_00101

Catalytic activity

CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein]. HAMAP MF_00101

Cofactor

Magnesium By similarity. HAMAP MF_00101

Subunit structure

Homotrimer.

Subcellular location

Cytoplasm By similarity HAMAP MF_00101.

Sequence similarities

Belongs to the P-Pant transferase superfamily. AcpS family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 120120Holo-[acyl-carrier-protein] synthase HAMAP MF_00101
PRO_0000175713

Sites

Metal binding81Magnesium By similarity
Metal binding581Magnesium By similarity

Secondary structure

1 .................... 120
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P0A2W6 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: 7FFB1848AC63DAEE

FASTA12013,388
        10         20         30         40         50         60 
MIVGHGIDIE ELASIESAVT RHEGFAKRVL TAQEMERFTS LKGRRQIEYL AGRWSAKEAF 

        70         80         90        100        110        120 
SKAMGTGISK LGFQDLEVLN NERGAPYFSQ APFSGKIWLS ISHTDQFVTA SVILEENHES

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE005672 Genomic DNA. Translation: AAK75777.1.
PIRH95197.
RefSeqNP_346137.1. NC_003028.3.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1FTEX-ray2.40A/B/C1-120[»]
1FTFX-ray2.05A/B/C1-120[»]
1FTHX-ray1.90A/B/C1-120[»]
ProteinModelPortalP0A2W6.
SMRP0A2W6. Positions 1-117.
ModBaseSearch...

Protein-protein interaction databases

IntActP0A2W6. 7 interactions.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTRT00000026679; EBSTRP00000025771; EBSTRG00000026679.
GeneID931136.
GenomeReviewsGene locus SP_1699 in contig AE005672_GR.
KEGGspn:SP_1699.
PATRIC19707841. VBIStrPne105772_1763.
TIGRSP_1699.

Phylogenomic databases

GeneTreeEBGT00050000027655.
HOGENOMHBG734479.
OMAVHVSITH.
ProtClustDBPRK00070.

Enzyme and pathway databases

BioCycSPNE170187-1:SP_1699-MONOMER.

Family and domain databases

HAMAPMF_00101. AcpS.
[Tree]
InterProIPR008278. 4-PPantetheinyl_Trfase.
IPR002582. ACPS.
IPR004568. PPantethiene-prot_Trfase.
[Graphical view]
Gene3DG3DSA:3.90.470.20. G3DSA:3.90.470.20. 1 hit.
KOK00997.
PfamPF01648. ACPS. 1 hit.
[Graphical view]
ProDomPD004282. PPantethiene-prot_Trfase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF56214. 4-PPT_transf. 1 hit.
TIGRFAMsTIGR00516. AcpS. 1 hit.
TIGR00556. Pantethn_trn. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACPS_STRPN
AccessionPrimary (citable) accession number: P0A2W6
Secondary accession number(s): Q9F7T5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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