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Reviewed, UniProtKB/Swiss-Prot P0A2W6 (ACPS_STRPN)

Last modified November 3, 2009. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Holo-[acyl-carrier-protein] synthase
      Short name=Holo-ACP synthase
    EC=2.7.8.7
Alternative name(s):
    4'-phosphopantetheinyl transferase acpS
Gene names
Name: acpS
Ordered Locus Names: SP_1699
OrganismStreptococcus pneumoniae [Complete proteome] [HAMAP]
Taxonomic identifier1313 [NCBI]
Taxonomic lineageBacteriaFirmicutesLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length120 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein By similarity.

Catalytic activity

CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein]. HAMAP MF_00101

Cofactor

Magnesium By similarity.

Subunit structure

Homotrimer. HAMAP MF_00101

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the P-Pant transferase superfamily. AcpS family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 120120Holo-[acyl-carrier-protein] synthase HAMAP MF_00101
PRO_0000175713

Sites

Metal binding81Magnesium By similarity
Metal binding581Magnesium By similarity

Secondary structure

.................... 120
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P0A2W6-1 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: 7FFB1848AC63DAEE

FASTA12013,388
        10         20         30         40         50         60 
MIVGHGIDIE ELASIESAVT RHEGFAKRVL TAQEMERFTS LKGRRQIEYL AGRWSAKEAF 

        70         80         90        100        110        120 
SKAMGTGISK LGFQDLEVLN NERGAPYFSQ APFSGKIWLS ISHTDQFVTA SVILEENHES 

« Hide

References

« Hide 'large scale' references
[1]"Complete genome sequence of a virulent isolate of Streptococcus pneumoniae."
Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D., Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J., Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D., Umayam L.A., White O., Salzberg S.L. expand/collapse author list , Lewis M.R., Radune D., Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L., McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K., Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A., Morrison D.A., Hollingshead S.K., Fraser C.M.
Science 293:498-506(2001) [PubMed: 11463916] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-334 / TIGR4.
[2]"Crystal structure of Streptococcus pneumoniae acyl carrier protein synthase: an essential enzyme in bacterial fatty acid biosynthesis."
Chirgadze N.Y., Briggs S.L., McAllister K.A., Fischl A.S., Zhao G.
EMBO J. 19:5281-5287(2000) [PubMed: 11032795] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF COMPLEX WITH 3'-5'-ADP.

Cross-references

Sequence databases

AE005672 Genomic DNA. Translation: AAK75777.1.
PIRH95197.
RefSeqNP_346137.1.

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1FTEX-ray2.40A/B/C1-120[»]
1FTFX-ray2.05A/B/C1-120[»]
1FTHX-ray1.90A/B/C1-120[»]
ModBaseSearch...

Protein-protein interaction databases

IntActP0A2W6. 6 interactions.

Genome annotation databases

GeneID931136.
GenomeReviewsGene locus SP_1699 in contig AE005672_GR.
KEGGspn:SP_1699.
TIGRSP_1699.

Phylogenomic databases

HOGENOMP0A2W6.
OMAVHVSITH.

Enzyme and pathway databases

BRENDA2.7.8.7. 600.

Family and domain databases

HAMAPMF_00101.
[Tree]
InterProIPR008278. 4-PPantetheinyl_Trfase.
IPR002582. ACPS.
IPR004568. PPantethiene-prot_Trfase.
[Graphical view]
PfamPF01648. ACPS. 1 hit.
[Graphical view]
ProDomPD004282. ACPS. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR00516. acpS. 1 hit.
TIGR00556. pantethn_trn. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACPS_STRPN
AccessionPrimary (citable) accession number: P0A2W6
Secondary accession number(s): Q9F7T5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: November 3, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents