P0A2W6 (ACPS_STRPN) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 66.
History...
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Holo-[acyl-carrier-protein] synthase Short name=Holo-ACP synthase EC=2.7.8.7 Alternative name(s): 4'-phosphopantetheinyl transferase AcpS | ||||
| Gene names |
| ||||
| Organism | Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 170187 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › ![]() |
Protein attributes
| Sequence length | 120 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein By similarity. HAMAP-Rule MF_00101 |
| Catalytic activity | CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein]. HAMAP-Rule MF_00101 |
| Cofactor | Magnesium By similarity. |
| Subunit structure | Homotrimer. Ref.2 |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the P-Pant transferase superfamily. AcpS family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Fatty acid biosynthesis Fatty acid metabolism Lipid biosynthesis Lipid metabolism |
| Cellular component | Cytoplasm |
| Ligand | Magnesium Metal-binding |
| Molecular function | Transferase |
| Technical term | 3D-structure Complete proteome |
| Gene Ontology (GO) | |
| Biological_process | fatty acid biosynthetic process Inferred from electronic annotation. Source: HAMAP macromolecule biosynthetic processInferred from electronic annotation. Source: InterPro |
| Cellular_component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | holo-[acyl-carrier-protein] synthase activity Inferred from electronic annotation. Source: HAMAP magnesium ion bindingInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| dnaJ | P95830 | 2 | EBI-2207344,EBI-2207079 | |
| gatC | Q97SE5 | 2 | EBI-2207344,EBI-2207053 | |
| groS | Q97NV3 | 2 | EBI-2207344,EBI-2206949 | |
| grpE | Q97S73 | 2 | EBI-2207344,EBI-2207065 | |
| uppS | Q97SR4 | 2 | EBI-2207344,EBI-2206983 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||||||||||||||||||||||||
Molecule processing | ||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 120 | 120 | Holo-[acyl-carrier-protein] synthase HAMAP-Rule MF_00101 | PRO_0000175713 | ||||||||||||||||||||||||||
Sites | ||||||||||||||||||||||||||||||
| Metal binding | 8 | 1 | Magnesium By similarity | |||||||||||||||||||||||||||
| Metal binding | 58 | 1 | Magnesium By similarity | |||||||||||||||||||||||||||
Secondary structure | ||||||||||||||||||||||||||||||
Helix Strand Turn | ||||||||||||||||||||||||||||||
| Beta strand | 2 – 11 | 10 | ||||||||||||||||||||||||||||
| Helix | 12 – 20 | 9 | ||||||||||||||||||||||||||||
| Helix | 25 – 29 | 5 | ||||||||||||||||||||||||||||
| Helix | 32 – 40 | 9 | ||||||||||||||||||||||||||||
| Helix | 43 – 63 | 21 | ||||||||||||||||||||||||||||
| Beta strand | 68 – 71 | 4 | ||||||||||||||||||||||||||||
| Helix | 73 – 75 | 3 | ||||||||||||||||||||||||||||
| Beta strand | 77 – 80 | 4 | ||||||||||||||||||||||||||||
| Beta strand | 86 – 90 | 5 | ||||||||||||||||||||||||||||
| Beta strand | 95 – 103 | 9 | ||||||||||||||||||||||||||||
| Beta strand | 105 – 115 | 11 | ||||||||||||||||||||||||||||
Sequences
References
| « Hide 'large scale' references | |
| [1] | "Complete genome sequence of a virulent isolate of Streptococcus pneumoniae." Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D., Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J., Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D., Umayam L.A., White O., Salzberg S.L. Fraser C.M.Science 293:498-506(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-334 / TIGR4. |
| [2] | "Crystal structure of Streptococcus pneumoniae acyl carrier protein synthase: an essential enzyme in bacterial fatty acid biosynthesis." Chirgadze N.Y., Briggs S.L., McAllister K.A., Fischl A.S., Zhao G. EMBO J. 19:5281-5287(2000) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF COMPLEX WITH 3'-5'-ADP, SUBUNIT. |
Cross-references
Sequence databases | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | AE005672 Genomic DNA. Translation: AAK75777.1. | ||||||||||||||||||||||||
| PIR | H95197. | ||||||||||||||||||||||||
| RefSeq | NP_346137.1. NC_003028.3. | ||||||||||||||||||||||||
3D structure databases | |||||||||||||||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||||||||||||||
| ProteinModelPortal | P0A2W6. | ||||||||||||||||||||||||
| SMR | P0A2W6. Positions 1-117. | ||||||||||||||||||||||||
| ModBase | Search... | ||||||||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||||||||
| IntAct | P0A2W6. 5 interactions. | ||||||||||||||||||||||||
| STRING | 170187.SP_1699. | ||||||||||||||||||||||||
Protocols and materials databases | |||||||||||||||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||||||||||||||
Genome annotation databases | |||||||||||||||||||||||||
| EnsemblBacteria | AAK75777; AAK75777; SP_1699. | ||||||||||||||||||||||||
| GeneID | 931136. | ||||||||||||||||||||||||
| KEGG | spn:SP_1699. | ||||||||||||||||||||||||
| PATRIC | 19707841. VBIStrPne105772_1763. | ||||||||||||||||||||||||
Organism-specific databases | |||||||||||||||||||||||||
| CMR | Search... | ||||||||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||||||||
| eggNOG | COG0736. | ||||||||||||||||||||||||
| HOGENOM | HOG000014315. | ||||||||||||||||||||||||
| KO | K00997. | ||||||||||||||||||||||||
| OMA | VHVSITH. | ||||||||||||||||||||||||
| ProtClustDB | PRK00070. | ||||||||||||||||||||||||
Family and domain databases | |||||||||||||||||||||||||
| Gene3D | 3.90.470.20. 1 hit. | ||||||||||||||||||||||||
| HAMAP | MF_00101. AcpS. | ||||||||||||||||||||||||
| InterPro | IPR008278. 4-PPantetheinyl_Trfase_SF. IPR002582. ACPS. IPR004568. PPantethiene-prot_Trfase_dom. [Graphical view] | ||||||||||||||||||||||||
| Pfam | PF01648. ACPS. 1 hit. [Graphical view] | ||||||||||||||||||||||||
| ProDom | PD004282. PPantethiene-prot_Trfase. 1 hit. [Graphical view] [Entries sharing at least one domain] | ||||||||||||||||||||||||
| SUPFAM | SSF56214. 4-PPT_transf. 1 hit. | ||||||||||||||||||||||||
| TIGRFAMs | TIGR00516. acpS. 1 hit. TIGR00556. pantethn_trn. 1 hit. | ||||||||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||||||||
Other | |||||||||||||||||||||||||
| EvolutionaryTrace | P0A2W6. | ||||||||||||||||||||||||
Entry information
| Entry name | ACPS_STRPN | ||||||||
| Accession | Primary (citable) accession number: P0A2W6 Secondary accession number(s): Q9F7T5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with
