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Protein

Chaperone protein IpgC

Gene

ipgC

Organism
Shigella flexneri
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Assists the correct folding of nascent IpaB. Once it is bound to IpaB, it binds to IpaC and impedes their premature association that would lead to their degradation in the absence of IpcG.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein IpgC
Gene namesi
Name:ipgC
Synonyms:ippI
Ordered Locus Names:CP0129
Encoded oniPlasmid pWR1004 Publications
Plasmid pMYSH60001 Publication
Plasmid pINV_F6_M13821 Publication
Plasmid pCP3011 Publication
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000001006 Componenti: Plasmid pCP301

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002064841 – 155Chaperone protein IpgCAdd BLAST155

Proteomic databases

PaxDbiP0A2U4.
PRIDEiP0A2U4.

Interactioni

Protein-protein interaction databases

DIPiDIP-45500N.
IntActiP0A2U4. 2 interactors.
STRINGi198214.CP0129.

Structurei

Secondary structure

1155
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 20Combined sources11
Helixi26 – 28Combined sources3
Helixi33 – 48Combined sources16
Helixi52 – 65Combined sources14
Helixi70 – 82Combined sources13
Helixi86 – 99Combined sources14
Beta strandi100 – 102Combined sources3
Helixi105 – 116Combined sources12
Helixi120 – 133Combined sources14
Helixi137 – 150Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3GYZX-ray2.15A/B1-151[»]
3GZ1X-ray2.15A/B1-151[»]
3GZ2X-ray2.65A/B1-151[»]
3KS2X-ray3.30A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R10-155[»]
ProteinModelPortaliP0A2U4.
SMRiP0A2U4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A2U4.

Family & Domainsi

Sequence similaritiesi

Belongs to the LcrH/SycD chaperone family.Curated

Phylogenomic databases

eggNOGiENOG4108Z19. Bacteria.
COG0457. LUCA.
HOGENOMiHOG000219447.
OMAiRCFGIVA.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR005415. T3SS_Ca_resp_chp_LcrH/SycD.
IPR016379. T3SS_Ca_resp_chp_LcrH/SycD_sub.
IPR011716. TPR-3.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF07720. TPR_3. 2 hits.
[Graphical view]
PIRSFiPIRSF003165. Chaperone_SicA. 1 hit.
PRINTSiPR01595. SYCDCHAPRONE.
SUPFAMiSSF48452. SSF48452. 1 hit.
TIGRFAMsiTIGR02552. LcrH_SycD. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A2U4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLNITENES ISTAVIDAIN SGATLKDINA IPDDMMDDIY SYAYDFYNKG
60 70 80 90 100
RIEEAEVFFR FLCIYDFYNV DYIMGLAAIY QIKEQFQQAA DLYAVAFALG
110 120 130 140 150
KNDYTPVFHT GQCQLRLKAP LKAKECFELV IQHSNDEKLK IKAQSYLDAI

QDIKE
Length:155
Mass (Da):17,756
Last modified:March 1, 2005 - v1
Checksum:iF46E39A92B8ADEC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86530 Genomic DNA. Translation: AAD15224.1.
M34849 Genomic DNA. Translation: AAA98423.1.
J04117 Genomic DNA. Translation: AAA26521.1.
X15319 Genomic DNA. Translation: CAA33380.1.
AL391753 Genomic DNA. Translation: CAC05804.1.
AF348706 Genomic DNA. Translation: AAK18447.1.
AY206439 Genomic DNA. Translation: AAP78992.1.
AF386526 Genomic DNA. Translation: AAL72340.1.
PIRiC34965.
RefSeqiNP_085291.1. NC_002698.1.
NP_858262.1. NC_004851.1.
WP_000055835.1. NZ_LVJC01000041.1.
YP_009062486.1. NC_024996.1.

Genome annotation databases

EnsemblBacteriaiAAL72340; AAL72340; SF_p0129.
GeneIDi1238043.
876446.
KEGGisfl:CP0129.
PATRICi18722587. VBIShiFle86970_5384.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86530 Genomic DNA. Translation: AAD15224.1.
M34849 Genomic DNA. Translation: AAA98423.1.
J04117 Genomic DNA. Translation: AAA26521.1.
X15319 Genomic DNA. Translation: CAA33380.1.
AL391753 Genomic DNA. Translation: CAC05804.1.
AF348706 Genomic DNA. Translation: AAK18447.1.
AY206439 Genomic DNA. Translation: AAP78992.1.
AF386526 Genomic DNA. Translation: AAL72340.1.
PIRiC34965.
RefSeqiNP_085291.1. NC_002698.1.
NP_858262.1. NC_004851.1.
WP_000055835.1. NZ_LVJC01000041.1.
YP_009062486.1. NC_024996.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3GYZX-ray2.15A/B1-151[»]
3GZ1X-ray2.15A/B1-151[»]
3GZ2X-ray2.65A/B1-151[»]
3KS2X-ray3.30A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R10-155[»]
ProteinModelPortaliP0A2U4.
SMRiP0A2U4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-45500N.
IntActiP0A2U4. 2 interactors.
STRINGi198214.CP0129.

Proteomic databases

PaxDbiP0A2U4.
PRIDEiP0A2U4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL72340; AAL72340; SF_p0129.
GeneIDi1238043.
876446.
KEGGisfl:CP0129.
PATRICi18722587. VBIShiFle86970_5384.

Phylogenomic databases

eggNOGiENOG4108Z19. Bacteria.
COG0457. LUCA.
HOGENOMiHOG000219447.
OMAiRCFGIVA.

Miscellaneous databases

EvolutionaryTraceiP0A2U4.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR005415. T3SS_Ca_resp_chp_LcrH/SycD.
IPR016379. T3SS_Ca_resp_chp_LcrH/SycD_sub.
IPR011716. TPR-3.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF07720. TPR_3. 2 hits.
[Graphical view]
PIRSFiPIRSF003165. Chaperone_SicA. 1 hit.
PRINTSiPR01595. SYCDCHAPRONE.
SUPFAMiSSF48452. SSF48452. 1 hit.
TIGRFAMsiTIGR02552. LcrH_SycD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIPGC_SHIFL
AccessioniPrimary (citable) accession number: P0A2U4
Secondary accession number(s): P18008
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: November 30, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Plasmid

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.