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Protein

Chaperone protein IpgC

Gene

ipgC

Organism
Shigella flexneri
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Assists the correct folding of nascent IpaB. Once it is bound to IpaB, it binds to IpaC and impedes their premature association that would lead to their degradation in the absence of IpcG.1 Publication

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processVirulence

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein IpgC
Gene namesi
Name:ipgC
Synonyms:ippI
Ordered Locus Names:CP0129
Encoded oniPlasmid pWR1004 Publications
Plasmid pMYSH60001 Publication
Plasmid pINV_F6_M13821 Publication
Plasmid pCP3011 Publication
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000001006 Componenti: Plasmid pCP301

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002064841 – 155Chaperone protein IpgCAdd BLAST155

Proteomic databases

PRIDEiP0A2U4

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

DIPiDIP-45500N
IntActiP0A2U4, 2 interactors

Structurei

Secondary structure

1155
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 20Combined sources11
Helixi26 – 28Combined sources3
Helixi33 – 48Combined sources16
Helixi52 – 65Combined sources14
Helixi70 – 82Combined sources13
Helixi86 – 99Combined sources14
Beta strandi100 – 102Combined sources3
Helixi105 – 116Combined sources12
Helixi120 – 133Combined sources14
Helixi137 – 150Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3GYZX-ray2.15A/B1-151[»]
3GZ1X-ray2.15A/B1-151[»]
3GZ2X-ray2.65A/B1-151[»]
3KS2X-ray3.30A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R10-155[»]
ProteinModelPortaliP0A2U4
SMRiP0A2U4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A2U4

Family & Domainsi

Sequence similaritiesi

Belongs to the LcrH/SycD chaperone family.Curated

Phylogenomic databases

eggNOGiENOG4108Z19 Bacteria
COG0457 LUCA
HOGENOMiHOG000219447
OMAiNEPRFPF

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR005415 T3SS_Ca_resp_chp_LcrH/SycD
IPR016379 T3SS_Ca_resp_chp_LcrH/SycD_sub
IPR011716 TPR-3
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF07720 TPR_3, 2 hits
PIRSFiPIRSF003165 Chaperone_SicA, 1 hit
PRINTSiPR01595 SYCDCHAPRONE
SUPFAMiSSF48452 SSF48452, 1 hit
TIGRFAMsiTIGR02552 LcrH_SycD, 1 hit

Sequencei

Sequence statusi: Complete.

P0A2U4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLNITENES ISTAVIDAIN SGATLKDINA IPDDMMDDIY SYAYDFYNKG
60 70 80 90 100
RIEEAEVFFR FLCIYDFYNV DYIMGLAAIY QIKEQFQQAA DLYAVAFALG
110 120 130 140 150
KNDYTPVFHT GQCQLRLKAP LKAKECFELV IQHSNDEKLK IKAQSYLDAI

QDIKE
Length:155
Mass (Da):17,756
Last modified:March 1, 2005 - v1
Checksum:iF46E39A92B8ADEC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86530 Genomic DNA Translation: AAD15224.1
M34849 Genomic DNA Translation: AAA98423.1
J04117 Genomic DNA Translation: AAA26521.1
X15319 Genomic DNA Translation: CAA33380.1
AL391753 Genomic DNA Translation: CAC05804.1
AF348706 Genomic DNA Translation: AAK18447.1
AY206439 Genomic DNA Translation: AAP78992.1
AF386526 Genomic DNA Translation: AAL72340.1
PIRiC34965
RefSeqiNP_085291.1, NC_002698.1
NP_858262.1, NC_004851.1
WP_000055835.1, NZ_MTPK01000040.1
YP_009062486.1, NC_024996.1

Genome annotation databases

EnsemblBacteriaiAAL72340; AAL72340; SF_p0129
GeneIDi1238043
876446
KEGGisfl:CP0129
PATRICifig|198214.7.peg.5384

Similar proteinsi

Entry informationi

Entry nameiIPGC_SHIFL
AccessioniPrimary (citable) accession number: P0A2U4
Secondary accession number(s): P18008
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: April 25, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Plasmid, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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