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P0A2T8

- FNR_SALTY

UniProt

P0A2T8 - FNR_SALTY

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Protein
Fumarate and nitrate reduction regulatory protein
Gene
fnr, oxrA, STM1660
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Global transcription factor that controls the expression of over 100 target genes in response to anoxia. It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metabolism. When the terminal electron acceptor, O2, is no longer available, it represses the synthesis of enzymes involved in aerobic respiration and increases the synthesis of enzymes required for anaerobic respiration By similarity.

Cofactori

Binds 1 4Fe-4S cluster per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi20 – 201Iron-sulfur (4Fe-4S) Reviewed prediction
Metal bindingi23 – 231Iron-sulfur (4Fe-4S) Reviewed prediction
Metal bindingi29 – 291Iron-sulfur (4Fe-4S) Reviewed prediction
Metal bindingi122 – 1221Iron-sulfur (4Fe-4S) Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi197 – 21620H-T-H motif By similarity
Add
BLAST

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
  4. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

4Fe-4S, DNA-binding, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciSENT99287:GCTI-1668-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Fumarate and nitrate reduction regulatory protein
Gene namesi
Name:fnr
Synonyms:oxrA
Ordered Locus Names:STM1660
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014: Chromosome

Subcellular locationi

Cytoplasm Inferred

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 250250Fumarate and nitrate reduction regulatory protein
PRO_0000100167Add
BLAST

Proteomic databases

PaxDbiP0A2T8.
PRIDEiP0A2T8.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi99287.STM1660.S.

Structurei

3D structure databases

ProteinModelPortaliP0A2T8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini164 – 23774HTH crp-type
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 2910Essential for the oxygen-regulated activity By similarity
Regioni47 – 504Activating region 2A Reviewed prediction
Regioni60 – 612Activating region 3A Reviewed prediction
Regioni71 – 755Activating region 1A Reviewed prediction
Regioni81 – 811Activating region 3B Reviewed prediction
Regioni85 – 873Activating region 3C Reviewed prediction
Regioni112 – 1121Activating region 3D Reviewed prediction
Regioni116 – 1216Activating region 1B Reviewed prediction
Regioni123 – 1242Activating region 2B Reviewed prediction
Regioni127 – 1282Activating region 2C Reviewed prediction
Regioni140 – 15920Dimerization Reviewed prediction
Add
BLAST
Regioni181 – 19111Activating region 1C Reviewed prediction
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0664.
KOiK01420.
OMAiFSANQFR.
OrthoDBiEOG6RVFWF.
PhylomeDBiP0A2T8.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00325. Crp. 1 hit.
[Graphical view]
PRINTSiPR00034. HTHCRP.
SMARTiSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A2T8-1 [UniParc]FASTAAdd to Basket

« Hide

MIPEKRIIRR IQSGGCAIHC QDCSISQLCI PFTLNEHELD QLDNIIERKK    50
PIQKGQTLFK AGDELKSLYA IRSGTIKSYT ITEQGDEQIT GFHLAGDLVG 100
FDAIGSGHHP SFAQALETSM VCEIPFETLD DLSGKMPNLR QQMMRLMSGE 150
IKGDQDMILL LSKKNAEERL AAFIYNLSRR FAQRGFSPRE FRLTMTRGDI 200
GNYLGLTVET ISRLLGRFQK SGMLAVKGKY ITIENSDALA ALAGHTRNVA 250
Length:250
Mass (Da):27,883
Last modified:March 1, 2005 - v1
Checksum:i33E3EFA2972FED2A
GO

Sequence cautioni

The sequence AAL20578.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U05668 Unassigned DNA. Translation: AAA16268.1.
AE006468 Genomic DNA. Translation: AAL20578.1. Different initiation.
RefSeqiNP_460619.2. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20578; AAL20578; STM1660.
GeneIDi1253178.
KEGGistm:STM1660.S.
PATRICi32381828. VBISalEnt20916_1754.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U05668 Unassigned DNA. Translation: AAA16268.1 .
AE006468 Genomic DNA. Translation: AAL20578.1 . Different initiation.
RefSeqi NP_460619.2. NC_003197.1.

3D structure databases

ProteinModelPortali P0A2T8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 99287.STM1660.S.

Proteomic databases

PaxDbi P0A2T8.
PRIDEi P0A2T8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL20578 ; AAL20578 ; STM1660 .
GeneIDi 1253178.
KEGGi stm:STM1660.S.
PATRICi 32381828. VBISalEnt20916_1754.

Phylogenomic databases

eggNOGi COG0664.
KOi K01420.
OMAi FSANQFR.
OrthoDBi EOG6RVFWF.
PhylomeDBi P0A2T8.

Enzyme and pathway databases

BioCyci SENT99287:GCTI-1668-MONOMER.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProi IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
PF00325. Crp. 1 hit.
[Graphical view ]
PRINTSi PR00034. HTHCRP.
SMARTi SM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Regulation of the Salmonella typhimurium pepT gene by cyclic AMP receptor protein (CRP) and FNR acting at a hybrid CRP-FNR site."
    Lombardo M.-J., Lee A.A., Knox T.M., Miller C.G.
    J. Bacteriol. 179:1909-1917(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiFNR_SALTY
AccessioniPrimary (citable) accession number: P0A2T8
Secondary accession number(s): P37428, P58996
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: July 9, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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