Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P0A2T8 (FNR_SALTY) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fumarate and nitrate reduction regulatory protein
Gene names
Name:fnr
Synonyms:oxrA
Ordered Locus Names:STM1660
OrganismSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [Reference proteome] [HAMAP]
Taxonomic identifier99287 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length250 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Global transcription factor that controls the expression of over 100 target genes in response to anoxia. It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metabolism. When the terminal electron acceptor, O2, is no longer available, it represses the synthesis of enzymes involved in aerobic respiration and increases the synthesis of enzymes required for anaerobic respiration By similarity.

Cofactor

Binds 1 4Fe-4S cluster per subunit By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm Probable.

Sequence similarities

Contains 1 cyclic nucleotide-binding domain.

Contains 1 HTH crp-type DNA-binding domain.

Sequence caution

The sequence AAL20578.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 250250Fumarate and nitrate reduction regulatory protein
PRO_0000100167

Regions

Domain164 – 23774HTH crp-type
DNA binding197 – 21620H-T-H motif By similarity
Region20 – 2910Essential for the oxygen-regulated activity By similarity
Region47 – 504Activating region 2A Potential
Region60 – 612Activating region 3A Potential
Region71 – 755Activating region 1A Potential
Region811Activating region 3B Potential
Region85 – 873Activating region 3C Potential
Region1121Activating region 3D Potential
Region116 – 1216Activating region 1B Potential
Region123 – 1242Activating region 2B Potential
Region127 – 1282Activating region 2C Potential
Region140 – 15920Dimerization Potential
Region181 – 19111Activating region 1C Potential

Sites

Metal binding201Iron-sulfur (4Fe-4S) Potential
Metal binding231Iron-sulfur (4Fe-4S) Potential
Metal binding291Iron-sulfur (4Fe-4S) Potential
Metal binding1221Iron-sulfur (4Fe-4S) Potential

Sequences

Sequence LengthMass (Da)Tools
P0A2T8 [UniParc].

Last modified March 1, 2005. Version 1.
Checksum: 33E3EFA2972FED2A

FASTA25027,883
        10         20         30         40         50         60 
MIPEKRIIRR IQSGGCAIHC QDCSISQLCI PFTLNEHELD QLDNIIERKK PIQKGQTLFK 

        70         80         90        100        110        120 
AGDELKSLYA IRSGTIKSYT ITEQGDEQIT GFHLAGDLVG FDAIGSGHHP SFAQALETSM 

       130        140        150        160        170        180 
VCEIPFETLD DLSGKMPNLR QQMMRLMSGE IKGDQDMILL LSKKNAEERL AAFIYNLSRR 

       190        200        210        220        230        240 
FAQRGFSPRE FRLTMTRGDI GNYLGLTVET ISRLLGRFQK SGMLAVKGKY ITIENSDALA 

       250 
ALAGHTRNVA 

« Hide

References

« Hide 'large scale' references
[1]"Regulation of the Salmonella typhimurium pepT gene by cyclic AMP receptor protein (CRP) and FNR acting at a hybrid CRP-FNR site."
Lombardo M.-J., Lee A.A., Knox T.M., Miller C.G.
J. Bacteriol. 179:1909-1917(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2."
McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. expand/collapse author list , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K.
Nature 413:852-856(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LT2 / SGSC1412 / ATCC 700720.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U05668 Unassigned DNA. Translation: AAA16268.1.
AE006468 Genomic DNA. Translation: AAL20578.1. Different initiation.
RefSeqNP_460619.2. NC_003197.1.

3D structure databases

ProteinModelPortalP0A2T8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING99287.STM1660.S.

Proteomic databases

PaxDbP0A2T8.
PRIDEP0A2T8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL20578; AAL20578; STM1660.
GeneID1253178.
KEGGstm:STM1660.S.
PATRIC32381828. VBISalEnt20916_1754.

Phylogenomic databases

eggNOGCOG0664.
KOK01420.
OMAFSANQFR.
OrthoDBEOG6RVFWF.
PhylomeDBP0A2T8.

Enzyme and pathway databases

BioCycSENT99287:GCTI-1668-MONOMER.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00027. cNMP_binding. 1 hit.
PF00325. Crp. 1 hit.
[Graphical view]
PRINTSPR00034. HTHCRP.
SMARTSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFNR_SALTY
AccessionPrimary (citable) accession number: P0A2T8
Secondary accession number(s): P37428, P58996
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: July 9, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families