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Protein

HTH-type transcriptional activator RhaS

Gene

rhaS

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Activates expression of the rhaBAD and rhaT operons.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi190 – 20920H-T-H motifUniRule annotationAdd
BLAST
DNA bindingi239 – 26224H-T-H motifUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Rhamnose metabolism, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciSENT99287:GCTI-4078-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional activator RhaSUniRule annotation
Alternative name(s):
L-rhamnose operon regulatory protein RhaSUniRule annotation
Gene namesi
Name:rhaSUniRule annotation
Synonyms:rhaC2
Ordered Locus Names:STM4048
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278HTH-type transcriptional activator RhaSPRO_0000194571Add
BLAST

Proteomic databases

PaxDbiP0A2S9.

Interactioni

Subunit structurei

Binds DNA as a dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei241 – 2411Interaction with sigma-70UniRule annotation
Sitei250 – 2501Interaction with sigma-70UniRule annotation

Protein-protein interaction databases

STRINGi99287.STM4048.

Structurei

3D structure databases

ProteinModelPortaliP0A2S9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 2 HTH araC/xylS-type DNA-binding domains.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4107S4Z. Bacteria.
ENOG410XT8S. LUCA.
HOGENOMiHOG000290513.
KOiK02855.
OMAiHYHDFHE.
PhylomeDBiP0A2S9.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
2.60.120.280. 1 hit.
HAMAPiMF_01534. HTH_type_RhaS. 1 hit.
InterProiIPR003313. AraC-bd.
IPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
IPR020449. Tscrpt_reg_HTH_AraC-type.
IPR023609. Tscrpt_reg_HTH_RhaS.
[Graphical view]
PfamiPF02311. AraC_binding. 1 hit.
PF12833. HTH_18. 1 hit.
[Graphical view]
PRINTSiPR00032. HTHARAC.
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
SSF51215. SSF51215. 1 hit.
PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A2S9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVLHSVDFF PSGKAPVAIE PRLPQAAFPE HHHDFHEIVI VEHGTGIHVF
60 70 80 90 100
NGQPYTISGG TVCFVRDHDR HLYEHTDNLC LTNVLWRSPD AFQFLAGLDQ
110 120 130 140 150
LLPQEQDGYY PSHWRVNQSV LQQVRQLVGL MERAGDGMDA PAVANREILF
160 170 180 190 200
MQLLVLLRRS SLMEGATNND AKLNQLMAWL EDHFAEEVCW EAVAEQFSLS
210 220 230 240 250
LRTLHRQLKQ HTGLTPQRYL NRLRLIKARH LLRHSDHSVT EIAYRCGFGD
260 270
SNHFSTLFRR EFNWSPRDIR QGRDAIIQ
Length:278
Mass (Da):32,089
Last modified:March 1, 2005 - v1
Checksum:iA8451BF20C1F4297
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti100 – 1045QLLPQ → HCCR in CAA40556 (PubMed:1657713).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57299 Genomic DNA. Translation: CAA40556.1.
AE006468 Genomic DNA. Translation: AAL22888.1.
PIRiJQ1288.
RefSeqiNP_462929.1. NC_003197.1.
WP_000217112.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL22888; AAL22888; STM4048.
GeneIDi1255575.
KEGGistm:STM4048.
PATRICi32386970. VBISalEnt20916_4265.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57299 Genomic DNA. Translation: CAA40556.1.
AE006468 Genomic DNA. Translation: AAL22888.1.
PIRiJQ1288.
RefSeqiNP_462929.1. NC_003197.1.
WP_000217112.1. NC_003197.1.

3D structure databases

ProteinModelPortaliP0A2S9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM4048.

Proteomic databases

PaxDbiP0A2S9.

Protocols and materials databases

DNASUi1255575.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL22888; AAL22888; STM4048.
GeneIDi1255575.
KEGGistm:STM4048.
PATRICi32386970. VBISalEnt20916_4265.

Phylogenomic databases

eggNOGiENOG4107S4Z. Bacteria.
ENOG410XT8S. LUCA.
HOGENOMiHOG000290513.
KOiK02855.
OMAiHYHDFHE.
PhylomeDBiP0A2S9.

Enzyme and pathway databases

BioCyciSENT99287:GCTI-4078-MONOMER.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
2.60.120.280. 1 hit.
HAMAPiMF_01534. HTH_type_RhaS. 1 hit.
InterProiIPR003313. AraC-bd.
IPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
IPR020449. Tscrpt_reg_HTH_AraC-type.
IPR023609. Tscrpt_reg_HTH_RhaS.
[Graphical view]
PfamiPF02311. AraC_binding. 1 hit.
PF12833. HTH_18. 1 hit.
[Graphical view]
PRINTSiPR00032. HTHARAC.
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
SSF51215. SSF51215. 1 hit.
PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRHAS_SALTY
AccessioniPrimary (citable) accession number: P0A2S9
Secondary accession number(s): P27029
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: September 7, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.