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P0A2P3

- SYW_SALTI

UniProt

P0A2P3 - SYW_SALTI

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Protein
Tryptophan--tRNA ligase
Gene
trpS, STY4315, t4024
Organism
Salmonella typhi
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei198 – 1981ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase (EC:6.1.1.2)
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name:
TrpRS
Gene namesi
Name:trpS
Ordered Locus Names:STY4315, t4024
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000000541: Chromosome, UP000002670: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 334334Tryptophan--tRNA ligaseUniRule annotation
PRO_0000136671Add
BLAST

Proteomic databases

PRIDEiP0A2P3.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi220341.STY4315.

Structurei

3D structure databases

ProteinModelPortaliP0A2P3.
SMRiP0A2P3. Positions 5-331.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi12 – 209"HIGH" regionUniRule annotation
Motifi195 – 1995"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0180.
HOGENOMiHOG000059940.
KOiK01867.
OMAiIDPKKHI.
OrthoDBiEOG686NJQ.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_B. Trp_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A2P3-1 [UniParc]FASTAAdd to Basket

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MTKPIVFSGA QPSGELTIGN YMGALRQWVN MQDDYHCIYC IVDQHAITVR    50
QDAQQLRKAT LDTLALYLAC GIDPEKSTIF VQSHVPEHAQ LGWALNCYTY 100
FGELSRMTQF KDKSARYAEN INAGLFDYPV LMAADILLYQ TNLVPVGEDQ 150
KQHLELSRDI AQRFNGLYGD IFKVPEPFIP KSGARVMSLL EPTKKMSKSD 200
DNRNNVIGLL EDPKSVVKKI KRAVTDSDEP PVVRYDVKEK AGVSNLLDIL 250
SAVTGQSIPE LEKQFEGKMY GHLKGEVAEA VSGMLSELQE RYHRFRNDEA 300
FLQKVMKDGA EKASARAAET LKAVYEAIGF VAKP 334
Length:334
Mass (Da):37,401
Last modified:March 15, 2005 - v1
Checksum:i23FD629E797E3992
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL513382 Genomic DNA. Translation: CAD08133.1.
AE014613 Genomic DNA. Translation: AAO71495.1.
RefSeqiNP_458423.1. NC_003198.1.
NP_807635.1. NC_004631.1.

Genome annotation databases

EnsemblBacteriaiAAO71495; AAO71495; t4024.
CAD08133; CAD08133; CAD08133.
GeneIDi1250532.
KEGGisty:STY4315.
PATRICi18546853. VBISalEnt120419_4410.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL513382 Genomic DNA. Translation: CAD08133.1 .
AE014613 Genomic DNA. Translation: AAO71495.1 .
RefSeqi NP_458423.1. NC_003198.1.
NP_807635.1. NC_004631.1.

3D structure databases

ProteinModelPortali P0A2P3.
SMRi P0A2P3. Positions 5-331.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220341.STY4315.

Proteomic databases

PRIDEi P0A2P3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO71495 ; AAO71495 ; t4024 .
CAD08133 ; CAD08133 ; CAD08133 .
GeneIDi 1250532.
KEGGi sty:STY4315.
PATRICi 18546853. VBISalEnt120419_4410.

Phylogenomic databases

eggNOGi COG0180.
HOGENOMi HOG000059940.
KOi K01867.
OMAi IDPKKHI.
OrthoDBi EOG686NJQ.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00140_B. Trp_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view ]
PANTHERi PTHR10055. PTHR10055. 1 hit.
Pfami PF00579. tRNA-synt_1b. 1 hit.
[Graphical view ]
PRINTSi PR01039. TRNASYNTHTRP.
TIGRFAMsi TIGR00233. trpS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CT18.
  2. "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
    Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
    J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700931 / Ty2.

Entry informationi

Entry nameiSYW_SALTI
AccessioniPrimary (citable) accession number: P0A2P3
Secondary accession number(s): Q8XGS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi