P0A2M7 (UXUA_SALTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannonate dehydratase
EC=4.2.1.8

Alternative name(s):
D-mannonate hydrolase

Gene names

Name:	uxuA
Ordered Locus Names:	STM3135

Organism

Salmonella typhimurium

Taxonomic identifier

90371 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	394 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP MF_00106
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00106
Sequence similarities	Belongs to the mannonate dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	mannonate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 394	394	Mannonate dehydratase HAMAP MF_00106		PRO_0000170685
Experimental info
	Sequence conflict	23	1	G → A Ref.2
	Sequence conflict	43 – 44	2	DE → AK Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P0A2M7 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: CA690041E17D119F	FASTA	394	44,937
	10 20 30 40 50 60 MKQTWRWYGP NDPVTLSDVR QAGATGVVTA LHHIPNGEIW SVDEIQKRKA IVEEAGLEWS 70 80 90 100 110 120 VVESVPIHED IKTHTGQYDL WIKNYQQTLR NLAQCGIYTV CYNFMPVLDW TRTDLEYVLP 130 140 150 160 170 180 DGSKALRFDQ IEFAAFELHI LKRPGAEADY TAEEIAQAER RFATMSEEDK ARLTRNIIAG 190 200 210 220 230 240 LPGAEEGYTL DQFRQHLATY KDIDKAKLRE HFAYFLKAII PVADEVGVRM AVHPDDPPRP 250 260 270 280 290 300 ILGLPRIVST IEDMQWMVET VNSMANGFTM CTGSYGVRAD NDLVDMIKQF GPRIYFTHLR 310 320 330 340 350 360 STLREENPKT FHEAAHLHGD VDMYEVVKAI VEEEHRRKAE GSDDLIPMRP DHGHQMLDDL 370 380 390 KKKTNPGYSA IGRLKGLAEV RGVELAIQRA FFSK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed: 11677609] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.
[2]	"Salmonella typhimurium loci involved in survival within macrophages." Baumler A.J., Kusters J.G., Stojiljkovic I., Heffron F. Infect. Immun. 62:1623-1630(1994) [PubMed: 8168923] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 20-50. Strain: ATCC 14028 / Isolates MS1633/MS6290.
[3]	Rudd K.E. Unpublished observations (JUL-1995) Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006468 Genomic DNA. Translation: AAL22009.1. U06130 Genomic DNA. No translation available. U06140 Genomic DNA. No translation available.
RefSeq	NP_462050.1. NC_003197.1.
3D structure databases
ProteinModelPortal	P0A2M7.
ModBase	Search...
Proteomic databases
PRIDE	P0A2M7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1254658.
GenomeReviews	Gene locus STM3135 in contig AE006468_GR.
KEGG	stm:STM3135.
PATRIC	32385031. VBISalEnt20916_3323.
Phylogenomic databases
HOGENOM	HBG585927.
OMA	VHEEIKT.
ProtClustDB	PRK03906.
Enzyme and pathway databases
BioCyc	STYP99287:STM3135-MONOMER.
Family and domain databases
HAMAP	MF_00106. UxuA. [Tree]
InterPro	IPR004628. Man_deHydtase. IPR013022. Xyl_isomerase-like_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
KO	K01686.
Pfam	PF03786. UxuA. 1 hit. [Graphical view]
PIRSF	PIRSF016049. Man_dehyd. 1 hit.
SUPFAM	SSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMs	TIGR00695. UxuA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UXUA_SALTY

Accession

Primary (citable) accession number: P0A2M7
Secondary accession number(s): P43668

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	March 15, 2005
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program