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Protein

Magnesium and cobalt efflux protein CorC

Gene

corC

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the transport of magnesium and cobalt ions.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Cobalt, Magnesium

Enzyme and pathway databases

BioCyciSENT99287:GCTI-670-MONOMER.

Protein family/group databases

TCDBi9.A.40.1.2. the hlyc/corc (hcc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Magnesium and cobalt efflux protein CorC
Gene namesi
Name:corC
Ordered Locus Names:STM0667
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Magnesium and cobalt efflux protein CorCPRO_0000088351Add
BLAST

Proteomic databases

PaxDbiP0A2L3.
PRIDEiP0A2L3.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM0667.

Structurei

Secondary structure

1
292
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi69 – 724Combined sources
Beta strandi73 – 753Combined sources
Helixi76 – 783Combined sources
Helixi88 – 9811Combined sources
Beta strandi101 – 1099Combined sources
Beta strandi113 – 1186Combined sources
Helixi119 – 1268Combined sources
Helixi135 – 1384Combined sources
Beta strandi144 – 1463Combined sources
Helixi151 – 16010Combined sources
Beta strandi165 – 1695Combined sources
Beta strandi175 – 1806Combined sources
Helixi181 – 1877Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3NQRX-ray2.00A/B/C/D65-191[»]
ProteinModelPortaliP0A2L3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A2L3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini73 – 13361CBS 1PROSITE-ProRule annotationAdd
BLAST
Domaini135 – 19561CBS 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the UPF0053 family.Curated
Contains 2 CBS domains.PROSITE-ProRule annotation

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

eggNOGiENOG4108JU5. Bacteria.
COG4535. LUCA.
HOGENOMiHOG000062294.
KOiK06189.
OMAiCARDILV.
OrthoDBiEOG60W7V4.
PhylomeDBiP0A2L3.

Family and domain databases

Gene3Di3.30.465.10. 1 hit.
InterProiIPR000644. CBS_dom.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR005170. Transptr-assoc_dom.
[Graphical view]
PfamiPF00571. CBS. 2 hits.
PF03471. CorC_HlyC. 1 hit.
[Graphical view]
SMARTiSM00116. CBS. 2 hits.
SM01091. CorC_HlyC. 1 hit.
[Graphical view]
SUPFAMiSSF56176. SSF56176. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A2L3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDDNSHSSD TVNSKKGFFS LLLSQLFHGE PKNRDELLAL IRDSGQNELI
60 70 80 90 100
DEDTRDMLEG VMDIADQRVR DIMIPRSQMI TLKRNQTLDE CLDVIIESAH
110 120 130 140 150
SRFPVISEDK DHIEGILMAK DLLPFMRSDA EAFSMDKVLR TAVVVPESKR
160 170 180 190 200
VDRMLKEFRS QRYHMAIVID EFGGVSGLVT IEDILELIVG EIEDEYDEED
210 220 230 240 250
DIDFRQLSRH TWTIRALASI EDFNDAFGTH FSDEEVDTIG GLVMQAFGHL
260 270 280 290
PARGETIDID GYQFKVAMAD SRRIIQVHVR IPDDSPQPKL DE
Length:292
Mass (Da):33,299
Last modified:March 15, 2005 - v1
Checksum:i54831AFCFACD2FBE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti122 – 1221L → F in AAC36474 (Ref. 1) Curated
Sequence conflicti191 – 1911E → V in AAC36474 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085347 Genomic DNA. Translation: AAC36474.1.
AE006468 Genomic DNA. Translation: AAL19618.1.
AF116773 Genomic DNA. Translation: AAD09823.1.
RefSeqiNP_459659.1. NC_003197.1.
WP_001278615.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL19618; AAL19618; STM0667.
GeneIDi1252187.
KEGGistm:STM0667.
PATRICi32379687. VBISalEnt20916_0703.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085347 Genomic DNA. Translation: AAC36474.1.
AE006468 Genomic DNA. Translation: AAL19618.1.
AF116773 Genomic DNA. Translation: AAD09823.1.
RefSeqiNP_459659.1. NC_003197.1.
WP_001278615.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3NQRX-ray2.00A/B/C/D65-191[»]
ProteinModelPortaliP0A2L3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM0667.

Protein family/group databases

TCDBi9.A.40.1.2. the hlyc/corc (hcc) family.

Proteomic databases

PaxDbiP0A2L3.
PRIDEiP0A2L3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL19618; AAL19618; STM0667.
GeneIDi1252187.
KEGGistm:STM0667.
PATRICi32379687. VBISalEnt20916_0703.

Phylogenomic databases

eggNOGiENOG4108JU5. Bacteria.
COG4535. LUCA.
HOGENOMiHOG000062294.
KOiK06189.
OMAiCARDILV.
OrthoDBiEOG60W7V4.
PhylomeDBiP0A2L3.

Enzyme and pathway databases

BioCyciSENT99287:GCTI-670-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP0A2L3.

Family and domain databases

Gene3Di3.30.465.10. 1 hit.
InterProiIPR000644. CBS_dom.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR005170. Transptr-assoc_dom.
[Graphical view]
PfamiPF00571. CBS. 2 hits.
PF03471. CorC_HlyC. 1 hit.
[Graphical view]
SMARTiSM00116. CBS. 2 hits.
SM01091. CorC_HlyC. 1 hit.
[Graphical view]
SUPFAMiSSF56176. SSF56176. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Magnesium transport in Salmonella typhimurium: sequence and characterization of the corB, corC, and corD genes."
    Smith R.L., Ahuga D., Thacker L.K., Maguire M.E.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: LT2.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.
  3. "Cloning and sequencing of apolipoprotein N-acyltransferase from Salmonella typhimurium."
    Gupta S.D., Rahman A., Wu H.C., Rick P.D.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 20-292.
    Strain: LEU485.
  4. "Magnesium transport in Salmonella typhimurium: the influence of new mutations conferring Co2+ resistance on the CorA Mg2+ transport system."
    Gibson M.M., Bagga D.A., Miller C.G., Maguire M.E.
    Mol. Microbiol. 5:2753-2762(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiCORC_SALTY
AccessioniPrimary (citable) accession number: P0A2L3
Secondary accession number(s): O87575, Q9R874
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: December 9, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.