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Protein

UTP--glucose-1-phosphate uridylyltransferase

Gene

galF

Organism
Salmonella typhi
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play a role in stationary phase survival.By similarity

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Pathwayi

GO - Molecular functioni

  1. enzyme regulator activity Source: InterPro
  2. UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipopolysaccharide biosynthetic process Source: UniProtKB-UniPathway
  2. UDP-glucose metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00030.
UPA00215.

Names & Taxonomyi

Protein namesi
Recommended name:
UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
Alternative name(s):
Alpha-D-glucosyl-1-phosphate uridylyltransferase
UDP-glucose pyrophosphorylase
Short name:
UDPGP
Uridine diphosphoglucose pyrophosphorylase
Gene namesi
Name:galF
Ordered Locus Names:STY2308, t0774
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000002670 Componenti: Chromosome UP000000541 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297UTP--glucose-1-phosphate uridylyltransferasePRO_0000201351Add
BLAST

Proteomic databases

PRIDEiP0A2K8.

Interactioni

Protein-protein interaction databases

STRINGi220341.STY2308.

Structurei

3D structure databases

ProteinModelPortaliP0A2K8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDPGP type 2 family.Curated

Phylogenomic databases

eggNOGiCOG1210.
HOGENOMiHOG000283477.
KOiK00963.
OMAiDYSYELE.
OrthoDBiEOG6Z9B3V.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005774. GalF.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR01105. galF. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A2K8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNLKAVIPV AGLGMHMLPA TKAIPKEMLP IVDKPMIQYI VDEIVAAGIK
60 70 80 90 100
EIVLVTHASK NAVENHFDTS YELESLLEQR VKRQLLAEVQ SICPPGVTIM
110 120 130 140 150
NVRQAQPLGL GHSILCARPV VGDNPFIVVL PDIIIDDATA DPLRYNLAAM
160 170 180 190 200
VARFNETGRS QVLAKRMKGD LSEYSVIQTK EPLDNEGKVS RIVEFIEKPD
210 220 230 240 250
QPQTLDSDLM AVGRYVLSAD IWAELERTEP GAWGRIQLTD AIAELAKKQS
260 270 280 290
VDAMLMTGDS YDCGKKMGYM QAFVKYGLRN LKEGAKFRKS IEQLLHE
Length:297
Mass (Da):32,958
Last modified:March 14, 2005 - v1
Checksum:i94A85A18934511D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA. Translation: CAD02461.1.
AE014613 Genomic DNA. Translation: AAO68465.1.
RefSeqiNP_456647.1. NC_003198.1.
NP_804616.1. NC_004631.1.

Genome annotation databases

EnsemblBacteriaiAAO68465; AAO68465; t0774.
CAD02461; CAD02461; CAD02461.
GeneIDi1248643.
KEGGisty:STY2308.
PATRICi18542557. VBISalEnt120419_2328.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA. Translation: CAD02461.1.
AE014613 Genomic DNA. Translation: AAO68465.1.
RefSeqiNP_456647.1. NC_003198.1.
NP_804616.1. NC_004631.1.

3D structure databases

ProteinModelPortaliP0A2K8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi220341.STY2308.

Proteomic databases

PRIDEiP0A2K8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO68465; AAO68465; t0774.
CAD02461; CAD02461; CAD02461.
GeneIDi1248643.
KEGGisty:STY2308.
PATRICi18542557. VBISalEnt120419_2328.

Phylogenomic databases

eggNOGiCOG1210.
HOGENOMiHOG000283477.
KOiK00963.
OMAiDYSYELE.
OrthoDBiEOG6Z9B3V.

Enzyme and pathway databases

UniPathwayiUPA00030.
UPA00215.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005774. GalF.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR01105. galF. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CT18.
  2. "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
    Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
    J. Bacteriol. 185:2330-2337(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700931 / Ty2.

Entry informationi

Entry nameiGALF_SALTI
AccessioniPrimary (citable) accession number: P0A2K8
Secondary accession number(s): P26390
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 14, 2005
Last sequence update: March 14, 2005
Last modified: January 6, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.