P0A2K7 (GALF_SALTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UTP--glucose-1-phosphate uridylyltransferase
EC=2.7.7.9

Alternative name(s):
Alpha-D-glucosyl-1-phosphate uridylyltransferase
UDP-glucose pyrophosphorylase
Short name=UDPGP
Uridine diphosphoglucose pyrophosphorylase

Gene names

Name:	galF
Ordered Locus Names:	STM2098

Organism

Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [Reference proteome] [HAMAP]

Taxonomic identifier

99287 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella › Salmonella choleraesuis › Salmonella enterica I › Salmonella typhimurium

Protein attributes

Sequence length	297 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May play a role in stationary phase survival.
Catalytic activity	UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.
Pathway	Carbohydrate metabolism; nucleotide-sugar metabolism. Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.
Sequence similarities	Belongs to the UDPGP type 2 family.

Ontologies

Keywords
Biological process	Lipopolysaccharide biosynthesis
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	UDP-glucose metabolic process Inferred from electronic annotation. Source: InterPro lipopolysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway regulation of catalytic activity Inferred from electronic annotation. Source: GOC
Molecular_function	UTP:glucose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC enzyme regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 297	297	UTP--glucose-1-phosphate uridylyltransferase		PRO_0000201352

Sequences

	Sequence		Length	Mass (Da)
	P0A2K7 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: 94A85A18934511D4	FASTA	297	32,958
	10 20 30 40 50 60 MMNLKAVIPV AGLGMHMLPA TKAIPKEMLP IVDKPMIQYI VDEIVAAGIK EIVLVTHASK 70 80 90 100 110 120 NAVENHFDTS YELESLLEQR VKRQLLAEVQ SICPPGVTIM NVRQAQPLGL GHSILCARPV 130 140 150 160 170 180 VGDNPFIVVL PDIIIDDATA DPLRYNLAAM VARFNETGRS QVLAKRMKGD LSEYSVIQTK 190 200 210 220 230 240 EPLDNEGKVS RIVEFIEKPD QPQTLDSDLM AVGRYVLSAD IWAELERTEP GAWGRIQLTD 250 260 270 280 290 AIAELAKKQS VDAMLMTGDS YDCGKKMGYM QAFVKYGLRN LKEGAKFRKS IEQLLHE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure and sequence of the rfb (O antigen) gene cluster of Salmonella serovar typhimurium (strain LT2)." Jiang X.-M., Neal B., Santiago F., Lee S.J., Romana L.K., Reeves P.R. Mol. Microbiol. 5:695-713(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: LT2.
[2]	"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X56793 Genomic DNA. Translation: CAA40114.1. AE006468 Genomic DNA. Translation: AAL21002.1.
RefSeq	NP_461043.1. NC_003197.1.
3D structure databases
ProteinModelPortal	P0A2K7.
ModBase	Search...
Protein-protein interaction databases
STRING	99287.STM2098.
Proteomic databases
PaxDb	P0A2K7.
PRIDE	P0A2K7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL21002; AAL21002; STM2098.
GeneID	1253619.
KEGG	stm:STM2098.
PATRIC	32382779. VBISalEnt20916_2220.
Phylogenomic databases
eggNOG	COG1210.
HOGENOM	HOG000283477.
KO	K00963.
OMA	IGAIGRY.
ProtClustDB	PRK10122.
Enzyme and pathway databases
UniPathway	UPA00030. UPA00215.
Family and domain databases
InterPro	IPR005774. GalF. IPR005835. NTP_transferase. [Graphical view]
Pfam	PF00483. NTP_transferase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01105. galF. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GALF_SALTY

Accession

Primary (citable) accession number: P0A2K7
Secondary accession number(s): P26390

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	March 15, 2005
Last modified:	May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program