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Protein

UTP--glucose-1-phosphate uridylyltransferase

Gene

galF

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play a role in stationary phase survival.

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Pathway:inucleotide-sugar metabolism

This protein is involved in the pathway nucleotide-sugar metabolism, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway nucleotide-sugar metabolism and in Carbohydrate metabolism.

Pathway:ilipopolysaccharide biosynthesis

This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.
View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciSENT99287:GCTI-2110-MONOMER.
UniPathwayiUPA00030.
UPA00215.

Names & Taxonomyi

Protein namesi
Recommended name:
UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
Alternative name(s):
Alpha-D-glucosyl-1-phosphate uridylyltransferase
UDP-glucose pyrophosphorylase
Short name:
UDPGP
Uridine diphosphoglucose pyrophosphorylase
Gene namesi
Name:galF
Ordered Locus Names:STM2098
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297UTP--glucose-1-phosphate uridylyltransferasePRO_0000201352Add
BLAST

Proteomic databases

PaxDbiP0A2K7.
PRIDEiP0A2K7.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM2098.

Structurei

3D structure databases

ProteinModelPortaliP0A2K7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDPGP type 2 family.Curated

Phylogenomic databases

eggNOGiCOG1210.
HOGENOMiHOG000283477.
KOiK00963.
OMAiDYSYELE.
OrthoDBiEOG6Z9B3V.
PhylomeDBiP0A2K7.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005774. GalF.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR01105. galF. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A2K7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNLKAVIPV AGLGMHMLPA TKAIPKEMLP IVDKPMIQYI VDEIVAAGIK
60 70 80 90 100
EIVLVTHASK NAVENHFDTS YELESLLEQR VKRQLLAEVQ SICPPGVTIM
110 120 130 140 150
NVRQAQPLGL GHSILCARPV VGDNPFIVVL PDIIIDDATA DPLRYNLAAM
160 170 180 190 200
VARFNETGRS QVLAKRMKGD LSEYSVIQTK EPLDNEGKVS RIVEFIEKPD
210 220 230 240 250
QPQTLDSDLM AVGRYVLSAD IWAELERTEP GAWGRIQLTD AIAELAKKQS
260 270 280 290
VDAMLMTGDS YDCGKKMGYM QAFVKYGLRN LKEGAKFRKS IEQLLHE
Length:297
Mass (Da):32,958
Last modified:March 15, 2005 - v1
Checksum:i94A85A18934511D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56793 Genomic DNA. Translation: CAA40114.1.
AE006468 Genomic DNA. Translation: AAL21002.1.
RefSeqiNP_461043.1. NC_003197.1.
WP_000981469.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL21002; AAL21002; STM2098.
GeneIDi1253619.
KEGGistm:STM2098.
PATRICi32382779. VBISalEnt20916_2220.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56793 Genomic DNA. Translation: CAA40114.1.
AE006468 Genomic DNA. Translation: AAL21002.1.
RefSeqiNP_461043.1. NC_003197.1.
WP_000981469.1. NC_003197.1.

3D structure databases

ProteinModelPortaliP0A2K7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM2098.

Proteomic databases

PaxDbiP0A2K7.
PRIDEiP0A2K7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL21002; AAL21002; STM2098.
GeneIDi1253619.
KEGGistm:STM2098.
PATRICi32382779. VBISalEnt20916_2220.

Phylogenomic databases

eggNOGiCOG1210.
HOGENOMiHOG000283477.
KOiK00963.
OMAiDYSYELE.
OrthoDBiEOG6Z9B3V.
PhylomeDBiP0A2K7.

Enzyme and pathway databases

UniPathwayiUPA00030.
UPA00215.
BioCyciSENT99287:GCTI-2110-MONOMER.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005774. GalF.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR01105. galF. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and sequence of the rfb (O antigen) gene cluster of Salmonella serovar typhimurium (strain LT2)."
    Jiang X.-M., Neal B., Santiago F., Lee S.J., Romana L.K., Reeves P.R.
    Mol. Microbiol. 5:695-713(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: LT2.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiGALF_SALTY
AccessioniPrimary (citable) accession number: P0A2K7
Secondary accession number(s): P26390
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: January 7, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.