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Protein

Histidine transport system permease protein HisQ

Gene

hisQ

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the histidine permease ABC transporter. Also part of a lysine/arginine/ornithine transporter. Probably responsible for the translocation of the substrate across the membrane. Required to relay the ATPase-inducing signal from the solute-binding protein to HisP.3 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Protein family/group databases

TCDBi3.A.1.3.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine transport system permease protein HisQ
Gene namesi
Name:hisQ
Ordered Locus Names:STM2353
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane 1 Publication; Multi-pass membrane protein PROSITE-ProRule annotation1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12PeriplasmicSequence analysisAdd BLAST12
Transmembranei13 – 33HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini34 – 58CytoplasmicSequence analysisAdd BLAST25
Transmembranei59 – 79HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini80 – 87PeriplasmicSequence analysis8
Transmembranei88 – 108HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini109 – 152CytoplasmicSequence analysisAdd BLAST44
Transmembranei153 – 173HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini174 – 194PeriplasmicSequence analysisAdd BLAST21
Transmembranei195 – 215HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini216 – 228CytoplasmicSequence analysisAdd BLAST13

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000600521 – 228Histidine transport system permease protein HisQAdd BLAST228

Proteomic databases

PaxDbiP0A2I9.

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (HisP), two transmembrane proteins (HisM and HisQ) and a solute-binding protein (HisJ or ArgT).4 Publications

Protein-protein interaction databases

STRINGi99287.STM2353.

Structurei

3D structure databases

ProteinModelPortaliP0A2I9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 212ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST200

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DSP. Bacteria.
COG4215. LUCA.
HOGENOMiHOG000267551.
KOiK10016.
OMAiMWLERRY.
PhylomeDBiP0A2I9.

Family and domain databases

CDDicd06261. TM_PBP2. 1 hit.
Gene3Di1.10.3720.10. 1 hit.
InterProiIPR010065. AA_ABC_transptr_permease_3TM.
IPR030199. HisQ.
IPR000515. MetI-like.
[Graphical view]
PANTHERiPTHR30133:SF1. PTHR30133:SF1. 1 hit.
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
TIGRFAMsiTIGR01726. HEQRo_perm_3TM. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A2I9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYGFSGVIL QGAIVTLELA LSSVVLAVLI GLVGAGAKLS QNRVTGLIFE
60 70 80 90 100
GYTTLIRGVP DLVLMLLIFY GLQIALNVVT DSLGIDQIDI DPMVAGIITL
110 120 130 140 150
GFIYGAYFTE TFRGAFMAVP KGHIEAATAF GFTHGQTFRR IMFPAMMRYA
160 170 180 190 200
LPGIGNNWQV ILKATALVSL LGLEDVVKAT QLAGKSTWEP FYFAVVCGLI
210 220
YLVFTTVSNG VLLLLERRYS VGVKRADL
Length:228
Mass (Da):24,620
Last modified:July 21, 1986 - v1
Checksum:i806DF4D82F7BCF69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01373 Genomic DNA. Translation: CAA24660.1.
J01805 Genomic DNA. Translation: AAA75579.1.
AE006468 Genomic DNA. Translation: AAL21254.1.
PIRiA03410. MMEBQT.
RefSeqiNP_461295.1. NC_003197.1.
WP_000965498.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL21254; AAL21254; STM2353.
GeneIDi1253875.
KEGGistm:STM2353.
PATRICi32383321. VBISalEnt20916_2490.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01373 Genomic DNA. Translation: CAA24660.1.
J01805 Genomic DNA. Translation: AAA75579.1.
AE006468 Genomic DNA. Translation: AAL21254.1.
PIRiA03410. MMEBQT.
RefSeqiNP_461295.1. NC_003197.1.
WP_000965498.1. NC_003197.1.

3D structure databases

ProteinModelPortaliP0A2I9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM2353.

Protein family/group databases

TCDBi3.A.1.3.1. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP0A2I9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL21254; AAL21254; STM2353.
GeneIDi1253875.
KEGGistm:STM2353.
PATRICi32383321. VBISalEnt20916_2490.

Phylogenomic databases

eggNOGiENOG4105DSP. Bacteria.
COG4215. LUCA.
HOGENOMiHOG000267551.
KOiK10016.
OMAiMWLERRY.
PhylomeDBiP0A2I9.

Family and domain databases

CDDicd06261. TM_PBP2. 1 hit.
Gene3Di1.10.3720.10. 1 hit.
InterProiIPR010065. AA_ABC_transptr_permease_3TM.
IPR030199. HisQ.
IPR000515. MetI-like.
[Graphical view]
PANTHERiPTHR30133:SF1. PTHR30133:SF1. 1 hit.
PfamiPF00528. BPD_transp_1. 1 hit.
[Graphical view]
SUPFAMiSSF161098. SSF161098. 1 hit.
TIGRFAMsiTIGR01726. HEQRo_perm_3TM. 1 hit.
PROSITEiPS50928. ABC_TM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHISQ_SALTY
AccessioniPrimary (citable) accession number: P0A2I9
Secondary accession number(s): P02913
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.