P0A2I0 (DSBA_SALEN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thiol:disulfide interchange protein DsbA

Gene names

Name:

dsbA

Organism

Salmonella enteritidis

Taxonomic identifier

149539 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. It is required for pilus biogenesis By similarity.
Subcellular location	Periplasm By similarity.
Sequence similarities	Belongs to the thioredoxin family. DsbA subfamily. Contains 1 thioredoxin domain.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Redox-active center Signal
PTM	Disulfide bond
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Cellular component	periplasmic space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	By similarity
	Chain	20 – 207	188	Thiol:disulfide interchange protein DsbA		PRO_0000034264
Regions
	Domain	20 – 158	139	Thioredoxin
Amino acid modifications
	Disulfide bond	49 ↔ 52		Redox-active By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0A2I0 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: 8260C50145FD3655	FASTA	207	22,911
	10 20 30 40 50 60 MKKIWLALAG MVLAFSASAA QISDGKQYIT LDKPVAGEPQ VLEFFSFYCP HCYQFEEVLH 70 80 90 100 110 120 VSDNVKKKLP EGTKMTKYHV EFLGPLGKEL TQAWAVAMAL GVEDKVTVPL FEAVQKTQTV 130 140 150 160 170 180 QSAADIRKVF VDAGVKGEDY DAAWNSFVVK SLVAQQEKAA ADLQLQGVPA MFVNGKYQIN 190 200 PQGMDTSSMD VFVQQYADTV KYLVDKK

References

[1]	Mendoza-del-Cueto M.T., Rotger-Anglada R. Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 82139.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF067152 Genomic DNA. Translation: AAC17906.1.
3D structure databases
ProteinModelPortal	P0A2I0.
SMR	P0A2I0. Positions 20-207.
ModBase	Search...
Proteomic databases
PRIDE	P0A2I0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001853. DSBA-like_thioredoxin_dom. IPR023205. Thiol:disulphide_interchange. IPR012336. Thioredoxin-like_fold. IPR017937. Thioredoxin_CS. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 2 hits.
Pfam	PF01323. DSBA. 1 hit. [Graphical view]
PIRSF	PIRSF001488. Tdi_protein. 1 hit.
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS00194. THIOREDOXIN_1. 1 hit. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DSBA_SALEN

Accession

Primary (citable) accession number: P0A2I0
Secondary accession number(s): O30848, O69191

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	March 15, 2005
Last modified:	December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program