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Protein

Protein translocase subunit SecE

Gene

secE

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecEUniRule annotation
Gene namesi
Name:secEUniRule annotation
Ordered Locus Names:STM4147
ORF Names:STMF1.6
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36HelicalUniRule annotationAdd BLAST21
Transmembranei41 – 61HelicalUniRule annotationAdd BLAST21
Transmembranei96 – 116HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001041721 – 127Protein translocase subunit SecEAdd BLAST127

Proteomic databases

PaxDbiP0A2D3.

Interactioni

Subunit structurei

Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.UniRule annotation

Protein-protein interaction databases

STRINGi99287.STM4147.

Family & Domainsi

Sequence similaritiesi

Belongs to the SecE/SEC61-gamma family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105PM1. Bacteria.
COG0690. LUCA.
HOGENOMiHOG000219148.
KOiK03073.
OMAiIVKWALV.
PhylomeDBiP0A2D3.

Family and domain databases

HAMAPiMF_00422. SecE. 1 hit.
InterProiIPR022943. SecE.
IPR005807. SecE_bac.
IPR001901. Translocase_SecE/Sec61-g.
[Graphical view]
PfamiPF00584. SecE. 1 hit.
[Graphical view]
PRINTSiPR01650. SECETRNLCASE.
TIGRFAMsiTIGR00964. secE_bact. 1 hit.
PROSITEiPS01067. SECE_SEC61G. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A2D3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSANTEAQGS GRGLEAMKWI VVAILLIVAI VGNYLYRDMM LPLRALAVVI
60 70 80 90 100
LIAAAGGVAL LTTKGKATVA FAREARTEVR KVIWPTRQET LHTTLIVAAV
110 120
TAVMSLILWG LDGILVRLVS FITGLRF
Length:127
Mass (Da):13,689
Last modified:March 15, 2005 - v1
Checksum:i640DB5C2080E775D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF170176 Genomic DNA. Translation: AAF33494.1.
AE006468 Genomic DNA. Translation: AAL22975.1.
RefSeqiNP_463016.1. NC_003197.1.
WP_001275691.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL22975; AAL22975; STM4147.
GeneIDi1255673.
KEGGistm:STM4147.
PATRICi32387175. VBISalEnt20916_4359.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF170176 Genomic DNA. Translation: AAF33494.1.
AE006468 Genomic DNA. Translation: AAL22975.1.
RefSeqiNP_463016.1. NC_003197.1.
WP_001275691.1. NC_003197.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM4147.

Proteomic databases

PaxDbiP0A2D3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL22975; AAL22975; STM4147.
GeneIDi1255673.
KEGGistm:STM4147.
PATRICi32387175. VBISalEnt20916_4359.

Phylogenomic databases

eggNOGiENOG4105PM1. Bacteria.
COG0690. LUCA.
HOGENOMiHOG000219148.
KOiK03073.
OMAiIVKWALV.
PhylomeDBiP0A2D3.

Family and domain databases

HAMAPiMF_00422. SecE. 1 hit.
InterProiIPR022943. SecE.
IPR005807. SecE_bac.
IPR001901. Translocase_SecE/Sec61-g.
[Graphical view]
PfamiPF00584. SecE. 1 hit.
[Graphical view]
PRINTSiPR01650. SECETRNLCASE.
TIGRFAMsiTIGR00964. secE_bact. 1 hit.
PROSITEiPS01067. SECE_SEC61G. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSECE_SALTY
AccessioniPrimary (citable) accession number: P0A2D3
Secondary accession number(s): Q9L9K1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: November 2, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.