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P0A2D0

- FABG_SALTI

UniProt

P0A2D0 - FABG_SALTI

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Protein

3-oxoacyl-[acyl-carrier-protein] reductase FabG

Gene
fabG, STY1234, t1725
Organism
Salmonella typhi
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis By similarity.

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371NADP By similarity
Metal bindingi50 – 501Calcium 1; via carbonyl oxygen; shared with dimeric partner By similarity
Metal bindingi53 – 531Calcium 1; via carbonyl oxygen; shared with dimeric partner By similarity
Binding sitei86 – 861NADP; via carbonyl oxygen By similarity
Binding sitei138 – 1381Substrate By similarity
Metal bindingi145 – 1451Calcium 2 By similarity
Active sitei151 – 1511Proton acceptor By similarity
Binding sitei184 – 1841NADP; via amide nitrogen and carbonyl oxygen By similarity
Metal bindingi233 – 2331Calcium 3; shared with dimeric partner By similarity
Metal bindingi234 – 2341Calcium 3; via carbonyl oxygen; shared with dimeric partner By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 154NADP By similarity
Nucleotide bindingi59 – 602NADP By similarity
Nucleotide bindingi151 – 1555NADP By similarity

GO - Molecular functioni

  1. 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW
  3. NAD binding Source: InterPro
  4. NADP binding Source: UniProtKB

GO - Biological processi

  1. fatty acid elongation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

Calcium, Metal-binding, NADP

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC:1.1.1.100)
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase
Gene namesi
Name:fabG
Ordered Locus Names:STY1234, t1725
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000000541: Chromosome, UP000002670: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2442443-oxoacyl-[acyl-carrier-protein] reductase FabGPRO_0000054680Add
BLAST

Proteomic databases

PRIDEiP0A2D0.

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

STRINGi220341.STY1234.

Structurei

3D structure databases

ProteinModelPortaliP0A2D0.
SMRiP0A2D0. Positions 2-244.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1028.
KOiK00059.
OMAiDEFGAID.
OrthoDBiEOG6N3CR8.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsiTIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A2D0-1 [UniParc]FASTAAdd to Basket

« Hide

MSFEGKIALV TGASRGIGRA IAETLVARGA KVIGTATSEN GAKNISDYLG    50
ANGKGLMLNV TDPASIESVL ENIRAEFGEV DILVNNAGIT RDNLLMRMKD 100
DEWNDIIETN LSSVFRLSKA VMRAMMKKRC GRIITIGSVV GTMGNAGQAN 150
YAAAKAGLIG FSKSLAREVA SRGITVNVVA PGFIETDMTR ALSDDQRAGI 200
LAQVPAGRLG GAQEIASAVA FLASDEASYI TGETLHVNGG MYMV 244
Length:244
Mass (Da):25,545
Last modified:March 15, 2005 - v1
Checksum:i86D71DA3E9AF0363
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL513382 Genomic DNA. Translation: CAD08319.1.
AE014613 Genomic DNA. Translation: AAO69349.1.
RefSeqiNP_455688.1. NC_003198.1.
NP_805500.1. NC_004631.1.

Genome annotation databases

EnsemblBacteriaiAAO69349; AAO69349; t1725.
CAD08319; CAD08319; CAD08319.
GeneIDi1247638.
KEGGisty:STY1234.
PATRICi18540341. VBISalEnt120419_1236.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL513382 Genomic DNA. Translation: CAD08319.1 .
AE014613 Genomic DNA. Translation: AAO69349.1 .
RefSeqi NP_455688.1. NC_003198.1.
NP_805500.1. NC_004631.1.

3D structure databases

ProteinModelPortali P0A2D0.
SMRi P0A2D0. Positions 2-244.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220341.STY1234.

Proteomic databases

PRIDEi P0A2D0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO69349 ; AAO69349 ; t1725 .
CAD08319 ; CAD08319 ; CAD08319 .
GeneIDi 1247638.
KEGGi sty:STY1234.
PATRICi 18540341. VBISalEnt120419_1236.

Phylogenomic databases

eggNOGi COG1028.
KOi K00059.
OMAi DEFGAID.
OrthoDBi EOG6N3CR8.

Enzyme and pathway databases

UniPathwayi UPA00094 .

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PRINTSi PR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsi TIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CT18.
  2. "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
    Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
    J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700931 / Ty2.

Entry informationi

Entry nameiFABG_SALTI
AccessioniPrimary (citable) accession number: P0A2D0
Secondary accession number(s): O85141
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Calcium ions stabilize the structure, and may inhibit FabG activity by obstructing access to the active site By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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