Reviewed, UniProtKB/Swiss-Prot P0A2C9 (FABG_SALTY)

Names and origin

Protein names

Recommended name:
    3-oxoacyl-[acyl-carrier-protein] reductase
    EC=1.1.1.100
Alternative name(s):
    3-ketoacyl-acyl carrier protein reductase

Gene names

Name:	fabG
Ordered Locus Names:	STM1195

Organism

Salmonella typhimurium [Complete proteome] [HAMAP]

Taxonomic identifier

90371 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella

Protein attributes

Sequence length	244 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.
Pathway	Lipid metabolism; fatty acid biosynthesis.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-oxoacyl-[acyl-carrier-protein] reductase activity Inferred from electronic annotation. Source: EC NAD or NADH binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 244	244	3-oxoacyl-[acyl-carrier-protein] reductase		PRO_0000054681
Regions
	Nucleotide binding	10 – 34	25	NADP By similarity
Sites
	Active site	151	1	Proton acceptor By similarity
	Binding site	138	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0A2C9-1 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: 86D71DA3E9AF0363	FASTA	244	25,545
	10 20 30 40 50 60 MSFEGKIALV TGASRGIGRA IAETLVARGA KVIGTATSEN GAKNISDYLG ANGKGLMLNV 70 80 90 100 110 120 TDPASIESVL ENIRAEFGEV DILVNNAGIT RDNLLMRMKD DEWNDIIETN LSSVFRLSKA 130 140 150 160 170 180 VMRAMMKKRC GRIITIGSVV GTMGNAGQAN YAAAKAGLIG FSKSLAREVA SRGITVNVVA 190 200 210 220 230 240 PGFIETDMTR ALSDDQRAGI LAQVPAGRLG GAQEIASAVA FLASDEASYI TGETLHVNGG MYMV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Transcriptional analysis of essential genes of the Escherichia coli fatty acid biosynthesis gene cluster by functional replacement with the analogous Salmonella typhimurium gene cluster." Zhang Y., Cronan J.E. Jr. J. Bacteriol. 180:3295-3303(1998) [PubMed: 9642179] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: LT2.
[2]	"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed: 11677609] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF044668 Genomic DNA. Translation: AAC38650.1. AE006468 Genomic DNA. Translation: AAL20124.1.
RefSeq	NP_460165.1.
3D structure databases
HSSP	HSSP built from PDB template 1EDO based on UniProtKB Q93X62.
SMR	P0A2C9. Positions 2-244.
ModBase	Search...
Proteomic databases
PRIDE	P0A2C9.
Genome annotation databases
GeneID	1252713.
GenomeReviews	Gene locus STM1195 in contig AE006468_GR.
KEGG	stm:STM1195.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P0A2C9.
OMA	AFLIRMT.
Enzyme and pathway databases
BioCyc	STYP99287:STM1195-MON.
BRENDA	1.1.1.100. 2.
Family and domain databases
InterPro	IPR011284. 3oxo_ACP_reduc. IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
TIGRFAMs	TIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FABG_SALTY

Accession

Primary (citable) accession number: P0A2C9
Secondary accession number(s): O85141

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	March 15, 2005
Last modified:	November 3, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)