SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P0A292

- DMA_SALTI

UniProt

P0A292 - DMA_SALTI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
DNA adenine methylase
Gene
dam, STY4312, t4022
Organism
Salmonella typhi
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a number of type II restriction endonucleases and methylases, it is thought to act in postreplication mismatch repair rather than as a part of a restriction modification system. May also play a role in DNA replication By similarity.

Catalytic activityi

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei10 – 101S-adenosyl-L-methionine By similarity
Binding sitei14 – 141S-adenosyl-L-methionine; via amide nitrogen By similarity
Binding sitei54 – 541S-adenosyl-L-methionine By similarity
Binding sitei181 – 1811S-adenosyl-L-methionine By similarity

GO - Molecular functioni

  1. nucleic acid binding Source: InterPro
  2. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

S-adenosyl-L-methionine

Protein family/group databases

REBASEi5691. M.StyCDamP.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA adenine methylase (EC:2.1.1.72)
Alternative name(s):
DNA adenine methyltransferase
Deoxyadenosyl-methyltransferase
M.StyDam
Gene namesi
Name:dam
Ordered Locus Names:STY4312, t4022
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000000541: Chromosome, UP000002670: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278DNA adenine methylase
PRO_0000087993Add
BLAST

Proteomic databases

PRIDEiP0A292.

Interactioni

Protein-protein interaction databases

STRINGi220341.STY4312.

Structurei

3D structure databases

ProteinModelPortaliP0A292.
SMRiP0A292. Positions 3-270.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0338.
HOGENOMiHOG000281348.
KOiK06223.
OMAiKFTREIY.
OrthoDBiEOG6CS08V.

Family and domain databases

Gene3Di1.10.1020.10. 1 hit.
3.40.50.150. 2 hits.
InterProiIPR023095. Ade_MeTrfase_dom_2.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR012263. M_m6A_EcoRV.
IPR012327. MeTrfase_D12.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF02086. MethyltransfD12. 1 hit.
[Graphical view]
PIRSFiPIRSF000398. M_m6A_EcoRV. 1 hit.
PRINTSiPR00505. D12N6MTFRASE.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00571. dam. 1 hit.
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A292-1 [UniParc]FASTAAdd to Basket

« Hide

MKKNRAFLKW AGGKYPLLDD IKRHLPKGEC LVEPFVGAGS VFLNTDFSRY    50
ILADINSDLI SLYNIVKLRT DEYVQASREL FMPETNQAEV YYQLREEFNT 100
CQDPFRRAVL FLYLNRYGYN GLCRYNLRGE FNVPFGRYKR PYFPEAELYH 150
FAEKAQNAFF YCESYADSMA RADKSSVVYC DPPYAPLSAT ANFTAYHTNS 200
FSLTQQAHLA EIAENLVSNR IPVLISNHDT ALTREWYQLA KLHVVKVRRS 250
ISSNGGTRKK VDELLALYQP GVATPARK 278
Length:278
Mass (Da):32,027
Last modified:March 15, 2005 - v1
Checksum:i900F4B77D827C3A8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL513382 Genomic DNA. Translation: CAD08130.1.
AE014613 Genomic DNA. Translation: AAO71492.1.
RefSeqiNP_458420.1. NC_003198.1.
NP_807632.1. NC_004631.1.

Genome annotation databases

EnsemblBacteriaiAAO71492; AAO71492; t4022.
CAD08130; CAD08130; CAD08130.
GeneIDi1250529.
KEGGisty:STY4312.
PATRICi18546847. VBISalEnt120419_4407.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL513382 Genomic DNA. Translation: CAD08130.1 .
AE014613 Genomic DNA. Translation: AAO71492.1 .
RefSeqi NP_458420.1. NC_003198.1.
NP_807632.1. NC_004631.1.

3D structure databases

ProteinModelPortali P0A292.
SMRi P0A292. Positions 3-270.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220341.STY4312.

Protein family/group databases

REBASEi 5691. M.StyCDamP.

Proteomic databases

PRIDEi P0A292.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO71492 ; AAO71492 ; t4022 .
CAD08130 ; CAD08130 ; CAD08130 .
GeneIDi 1250529.
KEGGi sty:STY4312.
PATRICi 18546847. VBISalEnt120419_4407.

Phylogenomic databases

eggNOGi COG0338.
HOGENOMi HOG000281348.
KOi K06223.
OMAi KFTREIY.
OrthoDBi EOG6CS08V.

Family and domain databases

Gene3Di 1.10.1020.10. 1 hit.
3.40.50.150. 2 hits.
InterProi IPR023095. Ade_MeTrfase_dom_2.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR012263. M_m6A_EcoRV.
IPR012327. MeTrfase_D12.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF02086. MethyltransfD12. 1 hit.
[Graphical view ]
PIRSFi PIRSF000398. M_m6A_EcoRV. 1 hit.
PRINTSi PR00505. D12N6MTFRASE.
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00571. dam. 1 hit.
PROSITEi PS00092. N6_MTASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CT18.
  2. "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
    Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
    J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700931 / Ty2.

Entry informationi

Entry nameiDMA_SALTI
AccessioniPrimary (citable) accession number: P0A292
Secondary accession number(s): P55893
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: June 11, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi