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P0A292

- DMA_SALTI

UniProt

P0A292 - DMA_SALTI

Protein

DNA adenine methylase

Gene

dam

Organism
Salmonella typhi
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Methylates DNA within the sequence GATC and protects the DNA from cleavage by the restriction endonuclease MboI. Although it shares sequence specificity with a number of type II restriction endonucleases and methylases, it is thought to act in postreplication mismatch repair rather than as a part of a restriction modification system. May also play a role in DNA replication By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei10 – 101S-adenosyl-L-methionineBy similarity
    Binding sitei14 – 141S-adenosyl-L-methionine; via amide nitrogenBy similarity
    Binding sitei54 – 541S-adenosyl-L-methionineBy similarity
    Binding sitei181 – 1811S-adenosyl-L-methionineBy similarity

    GO - Molecular functioni

    1. nucleic acid binding Source: InterPro
    2. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Protein family/group databases

    REBASEi5691. M.StyCDamP.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA adenine methylase (EC:2.1.1.72)
    Alternative name(s):
    DNA adenine methyltransferase
    Deoxyadenosyl-methyltransferase
    M.StyDam
    Gene namesi
    Name:dam
    Ordered Locus Names:STY4312, t4022
    OrganismiSalmonella typhi
    Taxonomic identifieri90370 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000000541: Chromosome, UP000002670: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 278278DNA adenine methylasePRO_0000087993Add
    BLAST

    Proteomic databases

    PRIDEiP0A292.

    Interactioni

    Protein-protein interaction databases

    STRINGi220341.STY4312.

    Structurei

    3D structure databases

    ProteinModelPortaliP0A292.
    SMRiP0A292. Positions 3-270.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the N(4)/N(6)-methyltransferase family.Curated

    Phylogenomic databases

    eggNOGiCOG0338.
    HOGENOMiHOG000281348.
    KOiK06223.
    OMAiKFTREIY.
    OrthoDBiEOG6CS08V.

    Family and domain databases

    Gene3Di1.10.1020.10. 1 hit.
    3.40.50.150. 2 hits.
    InterProiIPR023095. Ade_MeTrfase_dom_2.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR012263. M_m6A_EcoRV.
    IPR012327. MeTrfase_D12.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF02086. MethyltransfD12. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000398. M_m6A_EcoRV. 1 hit.
    PRINTSiPR00505. D12N6MTFRASE.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00571. dam. 1 hit.
    PROSITEiPS00092. N6_MTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0A292-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKNRAFLKW AGGKYPLLDD IKRHLPKGEC LVEPFVGAGS VFLNTDFSRY    50
    ILADINSDLI SLYNIVKLRT DEYVQASREL FMPETNQAEV YYQLREEFNT 100
    CQDPFRRAVL FLYLNRYGYN GLCRYNLRGE FNVPFGRYKR PYFPEAELYH 150
    FAEKAQNAFF YCESYADSMA RADKSSVVYC DPPYAPLSAT ANFTAYHTNS 200
    FSLTQQAHLA EIAENLVSNR IPVLISNHDT ALTREWYQLA KLHVVKVRRS 250
    ISSNGGTRKK VDELLALYQP GVATPARK 278
    Length:278
    Mass (Da):32,027
    Last modified:March 15, 2005 - v1
    Checksum:i900F4B77D827C3A8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL513382 Genomic DNA. Translation: CAD08130.1.
    AE014613 Genomic DNA. Translation: AAO71492.1.
    RefSeqiNP_458420.1. NC_003198.1.
    NP_807632.1. NC_004631.1.

    Genome annotation databases

    EnsemblBacteriaiAAO71492; AAO71492; t4022.
    CAD08130; CAD08130; CAD08130.
    GeneIDi1250529.
    KEGGisty:STY4312.
    PATRICi18546847. VBISalEnt120419_4407.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL513382 Genomic DNA. Translation: CAD08130.1 .
    AE014613 Genomic DNA. Translation: AAO71492.1 .
    RefSeqi NP_458420.1. NC_003198.1.
    NP_807632.1. NC_004631.1.

    3D structure databases

    ProteinModelPortali P0A292.
    SMRi P0A292. Positions 3-270.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 220341.STY4312.

    Protein family/group databases

    REBASEi 5691. M.StyCDamP.

    Proteomic databases

    PRIDEi P0A292.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO71492 ; AAO71492 ; t4022 .
    CAD08130 ; CAD08130 ; CAD08130 .
    GeneIDi 1250529.
    KEGGi sty:STY4312.
    PATRICi 18546847. VBISalEnt120419_4407.

    Phylogenomic databases

    eggNOGi COG0338.
    HOGENOMi HOG000281348.
    KOi K06223.
    OMAi KFTREIY.
    OrthoDBi EOG6CS08V.

    Family and domain databases

    Gene3Di 1.10.1020.10. 1 hit.
    3.40.50.150. 2 hits.
    InterProi IPR023095. Ade_MeTrfase_dom_2.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR012263. M_m6A_EcoRV.
    IPR012327. MeTrfase_D12.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF02086. MethyltransfD12. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000398. M_m6A_EcoRV. 1 hit.
    PRINTSi PR00505. D12N6MTFRASE.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00571. dam. 1 hit.
    PROSITEi PS00092. N6_MTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CT18.
    2. "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
      Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
      J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700931 / Ty2.

    Entry informationi

    Entry nameiDMA_SALTI
    AccessioniPrimary (citable) accession number: P0A292
    Secondary accession number(s): P55893
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3