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Protein

Peptide chain release factor 1

Gene

prfA

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.By similarity

GO - Molecular functioni

Keywordsi

Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide chain release factor 1
Short name:
RF-1
Gene namesi
Name:prfA
Ordered Locus Names:STM1776
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001777341 – 360Peptide chain release factor 1Add BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei235N5-methylglutamineBy similarity1

Post-translational modificationi

Methylated by PrmC. Methylation increases the termination efficiency of RF1 (By similarity).By similarity

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiP0A287.
PRIDEiP0A287.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM1776.

Structurei

3D structure databases

ProteinModelPortaliP0A287.
SMRiP0A287.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C8K. Bacteria.
COG0216. LUCA.
HOGENOMiHOG000074815.
KOiK02835.
OMAiWKVEIVS.
PhylomeDBiP0A287.

Family and domain databases

HAMAPiMF_00093. Rel_fac_1. 1 hit.
InterProiView protein in InterPro
IPR005139. PCRF.
IPR000352. Pep_chain_release_fac_I_II.
IPR004373. PrfA.
PfamiView protein in Pfam
PF03462. PCRF. 1 hit.
PF00472. RF-1. 1 hit.
SMARTiView protein in SMART
SM00937. PCRF. 1 hit.
TIGRFAMsiTIGR00019. prfA. 1 hit.
PROSITEiView protein in PROSITE
PS00745. RF_PROK_I. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A287-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPSIVAKLE ALHERHEEVQ ALLGDAGIIA DQDRFRALSR EYAQLSDVSR
60 70 80 90 100
CFTDWQQVQD DIETAQMMLD DPEMREMAQE ELREAKEKSE QLEQQLQVLL
110 120 130 140 150
LPKDPDDERN AFLEVRAGTG GDEAALFAGD LFRMYSRYAE ARRWRVEIMS
160 170 180 190 200
MSEGEHGGYK EIIAKISGDG VYGRLKFESG GHRVQRVPAT ESQGRIHTSA
210 220 230 240 250
CTVAVMPELP EAELPDINPA DLRIDTFRSS GAGGQHVNTT DSAIRITHLP
260 270 280 290 300
TGIVVECQDE RSQHKNKAKA LSVLGARIHA AETAKRQQAE ASTRRNLLGS
310 320 330 340 350
GDRSDRNRTY NFPQGRVTDH RINLTLYRLD ETMEGKLDML IEPIVQEHQA
360
DLLAALSEQE
Length:360
Mass (Da):40,461
Last modified:March 15, 2005 - v1
Checksum:i67AF15BF7ADB6755
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04243 Genomic DNA. Translation: AAA88611.1.
AE006468 Genomic DNA. Translation: AAL20691.1.
PIRiB32890.
RefSeqiNP_460732.1. NC_003197.2.
WP_000804703.1. NC_003197.2.

Genome annotation databases

EnsemblBacteriaiAAL20691; AAL20691; STM1776.
GeneIDi1253295.
KEGGistm:STM1776.
PATRICifig|99287.12.peg.1871.

Similar proteinsi

Entry informationi

Entry nameiRF1_SALTY
AccessioniPrimary (citable) accession number: P0A287
Secondary accession number(s): P13654
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: June 7, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families