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P0A270

- PPX_SALTI

UniProt

P0A270 - PPX_SALTI

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Protein

Exopolyphosphatase

Gene

ppx

Organism
Salmonella typhi
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate of circa 500 residues long, while chains of circa 15 residues compete poorly with polyphosphate as substrate (By similarity).By similarity

Catalytic activityi

(Polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate.

Cofactori

Mg2+By similarity

GO - Molecular functioni

  1. exopolyphosphatase activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro

GO - Biological processi

  1. polyphosphate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Exopolyphosphatase (EC:3.6.1.11)
Short name:
ExopolyPase
Alternative name(s):
Metaphosphatase
Gene namesi
Name:ppx
Ordered Locus Names:STY2743, t0355
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000000541: Chromosome, UP000002670: Chromosome

Subcellular locationi

Cell membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 513512ExopolyphosphatasePRO_0000194304Add
BLAST

Proteomic databases

PRIDEiP0A270.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi220341.STY2743.

Structurei

3D structure databases

ProteinModelPortaliP0A270.
SMRiP0A270. Positions 11-506.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GppA/Ppx family.Curated

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
KOiK01524.
OMAiENNKLLH.
OrthoDBiEOG6M6JN6.

Family and domain databases

InterProiIPR022371. Exopolyphosphatase.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03706. exo_poly_only. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A270-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPIYDKSPRP QEFAAVDLGS NSFHMVIARV VDGAMQIIGR LKQRVHLADG
60 70 80 90 100
LGADNKLSEE AMERGLSCLS LFAERLQGFS PSSVCIVGTH TLRQAQNAAD
110 120 130 140 150
FLKRAEKVIP YPIEIISGNE EARLIFMGVE HTQPEKGRKL VIDIGGGSTE
160 170 180 190 200
LVIGENFEPR LVESRRMGCV SFAQLYFPGG VINKENFQRA RMAAAQKLET
210 220 230 240 250
LTWQYRIQGW NVAMGASGTI KAAHEVLLAL GEKDGFITPE RLDKLKSEVL
260 270 280 290 300
KHRSFNALSL PGLSEERKAV FVPGLAILCG VFDALAIREL RLSDGALREG
310 320 330 340 350
VLYEMEGRFR HQDVRSRTAK SLANQYNIDR EQARRVLETT MQMYEQWQAQ
360 370 380 390 400
QPKLAHPQLE ALLRWAAMLH EVGLNINHSG LHRHSAYILQ HSDLPGFNQE
410 420 430 440 450
QQMMMATLVR YHRKAIKLDD MPRFTLFKKK QYLPLIQLLR LGVLLNNQRQ
460 470 480 490 500
ATTTPPTLRL TTDDSHWTLC FPHDWFSQNA LVLLDLEKEQ QYWEAVTGWR
510
LNIEEESSPE IAA
Length:513
Mass (Da):58,145
Last modified:January 23, 2007 - v2
Checksum:i02ACBA7895F2ED6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA. Translation: CAD02704.1.
AE014613 Genomic DNA. Translation: AAO68074.1.
RefSeqiNP_457037.1. NC_003198.1.
NP_804225.1. NC_004631.1.

Genome annotation databases

EnsemblBacteriaiAAO68074; AAO68074; t0355.
CAD02704; CAD02704; CAD02704.
GeneIDi1249057.
KEGGisty:STY2743.
PATRICi18543480. VBISalEnt120419_2781.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA. Translation: CAD02704.1 .
AE014613 Genomic DNA. Translation: AAO68074.1 .
RefSeqi NP_457037.1. NC_003198.1.
NP_804225.1. NC_004631.1.

3D structure databases

ProteinModelPortali P0A270.
SMRi P0A270. Positions 11-506.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220341.STY2743.

Proteomic databases

PRIDEi P0A270.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO68074 ; AAO68074 ; t0355 .
CAD02704 ; CAD02704 ; CAD02704 .
GeneIDi 1249057.
KEGGi sty:STY2743.
PATRICi 18543480. VBISalEnt120419_2781.

Phylogenomic databases

eggNOGi COG0248.
HOGENOMi HOG000258672.
KOi K01524.
OMAi ENNKLLH.
OrthoDBi EOG6M6JN6.

Family and domain databases

InterProi IPR022371. Exopolyphosphatase.
IPR003695. Ppx_GppA.
[Graphical view ]
Pfami PF02541. Ppx-GppA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03706. exo_poly_only. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CT18.
  2. "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
    Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
    J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700931 / Ty2.

Entry informationi

Entry nameiPPX_SALTI
AccessioniPrimary (citable) accession number: P0A270
Secondary accession number(s): O86091
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3