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Protein

Exopolyphosphatase

Gene

ppx

Organism
Salmonella typhi
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain.By similarity

Catalytic activityi

(Polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate.By similarity

Cofactori

Mg2+By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMagnesium

Names & Taxonomyi

Protein namesi
Recommended name:
ExopolyphosphataseBy similarity (EC:3.6.1.11By similarity)
Short name:
ExopolyPaseBy similarity
Gene namesi
Name:ppx
Ordered Locus Names:STY2743, t0355
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000002670 Componenti: Chromosome
  • UP000000541 Componenti: Chromosome

Subcellular locationi

  • Cell membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001943042 – 513ExopolyphosphataseAdd BLAST512

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi220341.STY2743.

Structurei

3D structure databases

ProteinModelPortaliP0A270.
SMRiP0A270.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GppA/Ppx family.Curated

Phylogenomic databases

eggNOGiENOG4105C9X. Bacteria.
COG0248. LUCA.
HOGENOMiHOG000258672.
KOiK01524.

Family and domain databases

InterProiView protein in InterPro
IPR022371. Exopolyphosphatase.
IPR003695. Ppx_GppA.
IPR030673. PyroPPase_GppA_Ppx.
PANTHERiPTHR30005:SF8. PTHR30005:SF8. 1 hit.
PfamiView protein in Pfam
PF02541. Ppx-GppA. 1 hit.
PIRSFiPIRSF001267. Pyrophosphatase_GppA_Ppx. 1 hit.
TIGRFAMsiTIGR03706. exo_poly_only. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A270-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIYDKSPRP QEFAAVDLGS NSFHMVIARV VDGAMQIIGR LKQRVHLADG
60 70 80 90 100
LGADNKLSEE AMERGLSCLS LFAERLQGFS PSSVCIVGTH TLRQAQNAAD
110 120 130 140 150
FLKRAEKVIP YPIEIISGNE EARLIFMGVE HTQPEKGRKL VIDIGGGSTE
160 170 180 190 200
LVIGENFEPR LVESRRMGCV SFAQLYFPGG VINKENFQRA RMAAAQKLET
210 220 230 240 250
LTWQYRIQGW NVAMGASGTI KAAHEVLLAL GEKDGFITPE RLDKLKSEVL
260 270 280 290 300
KHRSFNALSL PGLSEERKAV FVPGLAILCG VFDALAIREL RLSDGALREG
310 320 330 340 350
VLYEMEGRFR HQDVRSRTAK SLANQYNIDR EQARRVLETT MQMYEQWQAQ
360 370 380 390 400
QPKLAHPQLE ALLRWAAMLH EVGLNINHSG LHRHSAYILQ HSDLPGFNQE
410 420 430 440 450
QQMMMATLVR YHRKAIKLDD MPRFTLFKKK QYLPLIQLLR LGVLLNNQRQ
460 470 480 490 500
ATTTPPTLRL TTDDSHWTLC FPHDWFSQNA LVLLDLEKEQ QYWEAVTGWR
510
LNIEEESSPE IAA
Length:513
Mass (Da):58,145
Last modified:January 23, 2007 - v2
Checksum:i02ACBA7895F2ED6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513382 Genomic DNA. Translation: CAD02704.1.
AE014613 Genomic DNA. Translation: AAO68074.1.
RefSeqiNP_457037.1. NC_003198.1.
WP_001123330.1. NZ_MXPP01000011.1.

Genome annotation databases

EnsemblBacteriaiAAO68074; AAO68074; t0355.
CAD02704; CAD02704; CAD02704.
GeneIDi1249057.
KEGGistt:t0355.
sty:STY2743.
PATRICifig|220341.7.peg.2781.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPPX_SALTI
AccessioniPrimary (citable) accession number: P0A270
Secondary accession number(s): O86091
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: January 23, 2007
Last modified: July 5, 2017
This is version 78 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families