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P0A270

- PPX_SALTI

UniProt

P0A270 - PPX_SALTI

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Protein

Exopolyphosphatase

Gene
ppx, STY2743, t0355
Organism
Salmonella typhi
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate of circa 500 residues long, while chains of circa 15 residues compete poorly with polyphosphate as substrate By similarity.

Catalytic activityi

(Polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate.

Cofactori

Magnesium By similarity.

GO - Molecular functioni

  1. exopolyphosphatase activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro

GO - Biological processi

  1. polyphosphate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Exopolyphosphatase (EC:3.6.1.11)
Short name:
ExopolyPase
Alternative name(s):
Metaphosphatase
Gene namesi
Name:ppx
Ordered Locus Names:STY2743, t0355
OrganismiSalmonella typhi
Taxonomic identifieri90370 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000000541: Chromosome, UP000002670: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 513512ExopolyphosphatasePRO_0000194304Add
BLAST

Proteomic databases

PRIDEiP0A270.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi220341.STY2743.

Structurei

3D structure databases

ProteinModelPortaliP0A270.
SMRiP0A270. Positions 11-506.

Family & Domainsi

Sequence similaritiesi

Belongs to the GppA/Ppx family.

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
KOiK01524.
OMAiENNKLLH.
OrthoDBiEOG6M6JN6.

Family and domain databases

InterProiIPR022371. Exopolyphosphatase.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03706. exo_poly_only. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A270-1 [UniParc]FASTAAdd to Basket

« Hide

MPIYDKSPRP QEFAAVDLGS NSFHMVIARV VDGAMQIIGR LKQRVHLADG    50
LGADNKLSEE AMERGLSCLS LFAERLQGFS PSSVCIVGTH TLRQAQNAAD 100
FLKRAEKVIP YPIEIISGNE EARLIFMGVE HTQPEKGRKL VIDIGGGSTE 150
LVIGENFEPR LVESRRMGCV SFAQLYFPGG VINKENFQRA RMAAAQKLET 200
LTWQYRIQGW NVAMGASGTI KAAHEVLLAL GEKDGFITPE RLDKLKSEVL 250
KHRSFNALSL PGLSEERKAV FVPGLAILCG VFDALAIREL RLSDGALREG 300
VLYEMEGRFR HQDVRSRTAK SLANQYNIDR EQARRVLETT MQMYEQWQAQ 350
QPKLAHPQLE ALLRWAAMLH EVGLNINHSG LHRHSAYILQ HSDLPGFNQE 400
QQMMMATLVR YHRKAIKLDD MPRFTLFKKK QYLPLIQLLR LGVLLNNQRQ 450
ATTTPPTLRL TTDDSHWTLC FPHDWFSQNA LVLLDLEKEQ QYWEAVTGWR 500
LNIEEESSPE IAA 513
Length:513
Mass (Da):58,145
Last modified:January 23, 2007 - v2
Checksum:i02ACBA7895F2ED6D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL513382 Genomic DNA. Translation: CAD02704.1.
AE014613 Genomic DNA. Translation: AAO68074.1.
RefSeqiNP_457037.1. NC_003198.1.
NP_804225.1. NC_004631.1.

Genome annotation databases

EnsemblBacteriaiAAO68074; AAO68074; t0355.
CAD02704; CAD02704; CAD02704.
GeneIDi1249057.
KEGGisty:STY2743.
PATRICi18543480. VBISalEnt120419_2781.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL513382 Genomic DNA. Translation: CAD02704.1 .
AE014613 Genomic DNA. Translation: AAO68074.1 .
RefSeqi NP_457037.1. NC_003198.1.
NP_804225.1. NC_004631.1.

3D structure databases

ProteinModelPortali P0A270.
SMRi P0A270. Positions 11-506.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 220341.STY2743.

Proteomic databases

PRIDEi P0A270.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO68074 ; AAO68074 ; t0355 .
CAD02704 ; CAD02704 ; CAD02704 .
GeneIDi 1249057.
KEGGi sty:STY2743.
PATRICi 18543480. VBISalEnt120419_2781.

Phylogenomic databases

eggNOGi COG0248.
HOGENOMi HOG000258672.
KOi K01524.
OMAi ENNKLLH.
OrthoDBi EOG6M6JN6.

Family and domain databases

InterProi IPR022371. Exopolyphosphatase.
IPR003695. Ppx_GppA.
[Graphical view ]
Pfami PF02541. Ppx-GppA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03706. exo_poly_only. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CT18.
  2. "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18."
    Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.
    J. Bacteriol. 185:2330-2337(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700931 / Ty2.

Entry informationi

Entry nameiPPX_SALTI
AccessioniPrimary (citable) accession number: P0A270
Secondary accession number(s): O86091
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 58 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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