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P0A269

- PPX_SALTY

UniProt

P0A269 - PPX_SALTY

Protein

Exopolyphosphatase

Gene

ppx

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate of circa 500 residues long, while chains of circa 15 residues compete poorly with polyphosphate as substrate By similarity.By similarity

    Catalytic activityi

    (Polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate.

    Cofactori

    Magnesium.By similarity

    GO - Molecular functioni

    1. exopolyphosphatase activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro

    GO - Biological processi

    1. polyphosphate catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Magnesium

    Enzyme and pathway databases

    BioCyciSENT99287:GCTI-2518-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Exopolyphosphatase (EC:3.6.1.11)
    Short name:
    ExopolyPase
    Alternative name(s):
    Metaphosphatase
    Gene namesi
    Name:ppx
    Ordered Locus Names:STM2502
    OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
    Taxonomic identifieri99287 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000001014: Chromosome

    Subcellular locationi

    Cell membrane By similarity; Peripheral membrane protein By similarity

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 513512ExopolyphosphatasePRO_0000194305Add
    BLAST

    Proteomic databases

    PaxDbiP0A269.
    PRIDEiP0A269.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi99287.STM2502.

    Structurei

    3D structure databases

    ProteinModelPortaliP0A269.
    SMRiP0A269. Positions 11-506.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GppA/Ppx family.Curated

    Phylogenomic databases

    eggNOGiCOG0248.
    HOGENOMiHOG000258672.
    KOiK01524.
    OMAiENNKLLH.
    OrthoDBiEOG6M6JN6.
    PhylomeDBiP0A269.

    Family and domain databases

    InterProiIPR022371. Exopolyphosphatase.
    IPR003695. Ppx_GppA.
    [Graphical view]
    PfamiPF02541. Ppx-GppA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03706. exo_poly_only. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0A269-1 [UniParc]FASTAAdd to Basket

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    MPIYDKSPRP QEFAAVDLGS NSFHMVIARV VDGAMQIIGR LKQRVHLADG    50
    LGADNKLSEE AMERGLSCLS LFAERLQGFS PSSVCIVGTH TLRQAQNAAD 100
    FLKRAEKVIP YPIEIISGNE EARLIFMGVE HTQPEKGRKL VIDIGGGSTE 150
    LVIGENFEPR LVESRRMGCV SFAQLYFPGG VINKENFQRA RMAAAQKLET 200
    LTWQYRIQGW NVAMGASGTI KAAHEVLLAL GEKDGFITPE RLDKLKSEVL 250
    KHRSFNALSL PGLSEERKAV FVPGLAILCG VFDALAIREL RLSDGALREG 300
    VLYEMEGRFR HQDVRSRTAK SLANQYNIDR EQARRVLETT MQMYEQWQAQ 350
    QPKLAHPQLE ALLRWAAMLH EVGLNINHSG LHRHSAYILQ HSDLPGFNQE 400
    QQMMMATLVR YHRKAIKLDD MPRFTLFKKK QYLPLIQLLR LGVLLNNQRQ 450
    ATTTPPTLRL TTDDSHWTLC FPHDWFSQNA LVLLDLEKEQ QYWEAVTGWR 500
    LNIEEESSPE IAA 513
    Length:513
    Mass (Da):58,145
    Last modified:January 23, 2007 - v2
    Checksum:i02ACBA7895F2ED6D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF085682 Genomic DNA. Translation: AAC34891.1.
    AE006468 Genomic DNA. Translation: AAL21396.1.
    RefSeqiNP_461437.1. NC_003197.1.

    Genome annotation databases

    EnsemblBacteriaiAAL21396; AAL21396; STM2502.
    GeneIDi1254024.
    KEGGistm:STM2502.
    PATRICi32383637. VBISalEnt20916_2641.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF085682 Genomic DNA. Translation: AAC34891.1 .
    AE006468 Genomic DNA. Translation: AAL21396.1 .
    RefSeqi NP_461437.1. NC_003197.1.

    3D structure databases

    ProteinModelPortali P0A269.
    SMRi P0A269. Positions 11-506.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 99287.STM2502.

    Proteomic databases

    PaxDbi P0A269.
    PRIDEi P0A269.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL21396 ; AAL21396 ; STM2502 .
    GeneIDi 1254024.
    KEGGi stm:STM2502.
    PATRICi 32383637. VBISalEnt20916_2641.

    Phylogenomic databases

    eggNOGi COG0248.
    HOGENOMi HOG000258672.
    KOi K01524.
    OMAi ENNKLLH.
    OrthoDBi EOG6M6JN6.
    PhylomeDBi P0A269.

    Enzyme and pathway databases

    BioCyci SENT99287:GCTI-2518-MONOMER.

    Family and domain databases

    InterProi IPR022371. Exopolyphosphatase.
    IPR003695. Ppx_GppA.
    [Graphical view ]
    Pfami PF02541. Ppx-GppA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03706. exo_poly_only. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Polyphosphate kinase (ppk) and exopolyphosphatase (ppx) genes in Salmonella typhimurium."
      Kim K.S., Fraley C.D., Kornberg A.
      Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: WRAY.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LT2 / SGSC1412 / ATCC 700720.

    Entry informationi

    Entry nameiPPX_SALTY
    AccessioniPrimary (citable) accession number: P0A269
    Secondary accession number(s): O86091
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 57 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3