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P0A267 (GPPA_SALTY) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

EC=3.6.1.40
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene names
Name:gppA
Ordered Locus Names:STM3913
ORF Names:STMD1.78
OrganismSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [Reference proteome] [HAMAP]
Taxonomic identifier99287 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length493 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity. HAMAP-Rule MF_01550

Catalytic activity

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate. HAMAP-Rule MF_01550

Pathway

Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2. HAMAP-Rule MF_01550

Sequence similarities

Belongs to the GppA/Ppx family. GppA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 493493Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase HAMAP-Rule MF_01550
PRO_0000194289

Sequences

Sequence LengthMass (Da)Tools
P0A267 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: 992697E61F583EF0

FASTA49354,816
        10         20         30         40         50         60 
MNSTSLYAAI DLGSNSFHML VVREAAGSIQ TLTRIKRKVR LAAGLNNDNH LSAEAMERGW 

        70         80         90        100        110        120 
QCLRLFAERL QDIPQPQIRV VATATLRLAV NAGEFIAKAQ TILGCPVQVI SGEEEARLIY 

       130        140        150        160        170        180 
QGVAHTTGGA DQRLVVDIGG ASTELVTGTG AQTTSLFSLS MGCVTWLERY FSDRNLAQEN 

       190        200        210        220        230        240 
FDDAEKAARD VLRPVADELR FHGWKVCVGA SGTVQALQEI MMAQGMDERI TLAKLQQLKQ 

       250        260        270        280        290        300 
RAIQCGRLEE LEIEGLTLER ALVFPSGLAI LIAIFTELNI QSMTLAGGAL REGLVYGMLH 

       310        320        330        340        350        360 
LAVDQDIRSR TLRNIQRRFI VDTDQANRVA KLADNFLKQV ENAWHIEPIS RELLLSACQL 

       370        380        390        400        410        420 
HEIGLSVDFK QAPYHAAYLV RHLDLPGYTP AQKKLLATLL LNQTNPVDLS SLHQQNAVPP 

       430        440        450        460        470        480 
RVAEQLCRLL RLAILFAGRR RDDLVPEITL QALNENLTLT LPGDWLAHHP LGKELIDQES 

       490 
QWQSYVHWPL DVR 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF233324 Genomic DNA. Translation: AAF33473.1.
AE006468 Genomic DNA. Translation: AAL22763.1.
RefSeqNP_462804.1. NC_003197.1.

3D structure databases

ProteinModelPortalP0A267.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING99287.STM3913.

Proteomic databases

PRIDEP0A267.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL22763; AAL22763; STM3913.
GeneID1255439.
KEGGstm:STM3913.
PATRIC32386691. VBISalEnt20916_4135.

Phylogenomic databases

HOGENOMHOG000258672.
KOK01524.
OMAGLHIEYK.
OrthoDBEOG6M6JN6.
PhylomeDBP0A267.

Enzyme and pathway databases

BioCycSENT99287:GCTI-3942-MONOMER.
UniPathwayUPA00908; UER00884.

Family and domain databases

HAMAPMF_01550. GppA.
InterProIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamPF02541. Ppx-GppA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPPA_SALTY
AccessionPrimary (citable) accession number: P0A267
Secondary accession number(s): Q9L6S0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: July 9, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways